Results 51 to 60 of about 2,758,127 (153)

Discovery of Highly Potent and Selective Thyroid Hormone Receptor β Agonists for the Treatment of Nonalcoholic Steatohepatitis

, 2023
Nonalcoholic steatohepatitis (NASH) is a progressive stage of nonalcoholic fatty liver disease (NAFLD) and is characterized by steatosis, inflammation, hepatocyte ballooning, and fibrosis.
Yi Zhang (9093), Ju Liang (4277062), Yipei Gu (14640929), Junli Yang (3729031), Ying Leng (1613104), Bing Zhou (168418), Mengmeng Ning (1613110), Yaxi Yang (1581025), Hui Qu (1417882), Liuyu Hu (8267328)   +9 more
core   +2 more sources

Expanding the Role of Thyroid-Stimulating Hormone in Skeletal Physiology

Frontiers in Endocrinology, 2017
The dogma that thyroid-stimulating hormone (TSH) solely regulates the production of thyroid hormone from the thyroid gland has hampered research on its wider physiological roles. The action of pituitary TSH on the skeleton has now been well described; in
Ramkumarie Baliram, Rauf Latif, Mone Zaidi, Terry F. Davies, Terry F. Davies   +4 more
doaj   +1 more source

A computational insight into endocrine disruption by polychlorinated biphenyls via non-covalent interactions with human nuclear receptors

Ecotoxicology and Environmental Safety, 2021
Production of polychlorinated biphenyls (PCBs) was banned a long time ago because of their harmful health effects but humans continue to be exposed to residual PCBs in the environment.
Lukman K. Akinola, Adamu Uzairu, Gideon A. Shallangwa, Stephen E. Abechi   +3 more
doaj   +1 more source

Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]

, 2017
It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co ...
Indarto, Dono, Izawa, Masao
core  

Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. [PDF]

, 1993
Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breast ...
Herzinger, Thomas, Blasschke, Dorothea, Hermeking, H., Hörz, W., Herzinger, T., Blaschke, D., Hörz, Wolfram, Wolf, Dieter A., Hermeking, Heiko, Wolf, D.A.   +9 more
core   +1 more source

Thyroid hormone resistance syndromes: Emerging insights and clinical implications

Thyroid Research & Practice
Thyroid hormone resistance syndromes (RTH) represent rare disorders characterized by reduced tissue responsiveness to circulating thyroid hormones, leading to variable biochemical and clinical manifestations. Despite elevated serum thyroid hormone levels,
Richa Chaturvedi, Aprajita Pradhan, Anu Mathew, Monika Goyal, Monika Sharma, Varsha Kachroo, Vaishali Naik, Savita Jain, Sakshi Gagneja, Shruthi Bettegowda   +9 more
doaj   +1 more source

Dual COX-2/5-LOX inhibitors from Zanthoxylum simulans inhibit gastric cancer cells by cross-mediating thyroid, estrogen, and oxytocin signaling pathways

Frontiers in Chemistry
Cyclooxygenase 2 (COX-2) and 5-lipoxygenase (5-LOX) are overexpressed in gastric cancer cells, the dual inhibitors of which exhibit potential against metastasis and invasion with fewer side effects.
Yong-Qiang Tian, Jing Liu, Peng Cheng, Jian Zou, Hui-Fang Xu, Xin-Hua Shi, Yi-Sheng Zhang, Ling Mei   +7 more
doaj   +1 more source

A New Point Mutation (A420G) in the Thyroid Hormone Receptor-β Gene of a Patient with Resistance to Thyroid Hormone [PDF]

, 1995
Resistance to thyroid hormone (RTH) is a syndrome of reduced responsiveness of tissues to thyroid hormone. We present a new point mutation at nucleotide 1544 of the T_3 binding region of thyroid hormone receptor-β(TR β) resulting in a lysine to arginine ...
Villadolid, Maria C.
core  

Thyroid hormone receptor alpha(1) regulates expression of the na+/H+ exchanger (NHE1)

, 2002
In this paper we examine the role of thyroid hormone in regulating expression of the Na+/H+ exchanger. Thyroid hormone has been reported to regulate the activity of the Na+/H+ exchanger messenger RNA in some cell types. Treatment of cardiac myocytes with
Rieder, Carmen V., Misik, Angelika J., Li, Xiuju J., Fliegel, Larry, Solaro, R. John, Lowen, Anice   +5 more
core   +1 more source

RESISTANCE TO THYROID HORMONE DUE TO A NOVEL THR- MUTATION IN A PATIENT WITH THYROID AGENESIS

, 2018
Refetoff Syndrome is a rare disorder characterized by resistance to thyroid hormone (RTH). The coexistence of RTH and thyroid dysgenesis is a rare event. Up to now, only four cases of ectopic gland and RTH have been reported.
Maria Scavone
core   +1 more source