Results 71 to 80 of about 2,758,127 (153)

Reactivated thyroid hormone receptor β attenuates anaplastic thyroid cancer (ATC) stem cell activity. [PDF]

Endocr Relat Cancer, 2023
Zhu X, Zhao L, Doolittle WKL, Cheng SY.
europepmc   +1 more source

Resistance to Thyroid Hormone in the Absence of Mutations in the Thyroid Hormone Receptor Genes

, 2004
Resistance to thyroid hormone (RTH) is a syndrome of reduced tissue sensitivity to thyroid hormone. In the majority of subjects, RTH is caused by mutant thyroid hormone receptors (TR) ß molecules that interfere with the function of the normal TRß, thus ...
Refetoff, Samuel, Reutrakul, Sirimon, Sadow, Peter M, Mannavola, Deborah, Pohlenz, Joachim, Weiss, Roy E, Dennis, Kimberly, Kimberly Dennis, Samuel Refetoff, Deborah Mannavola, Roy E. Weiss, Sirimon Reutrakul, Joachim Pohlenz, Peter M. Sadow   +13 more
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Resistance to thyroid hormone associated with a novel mutation of the thyroid β receptor gene in a four-year-old female [PDF]

, 2011
Resistance to thyroid hormone (RTH) is a rare syndrome of reduced responsiveness of target tissues to thyroid hormone and is caused mutation in the thyroid β receptor gene. We report a novel mutation, E445X, causing RTH in a 4-year old girl.
Karina T Canadas, Christopher K Breuer, Robert Udelsman, Scott A Rivkees   +3 more
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An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell-specific over-expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary-selective resistance to thyroid hormone

Journal of Translational Medicine, 2011
Background The syndrome of resistance to thyroid hormone (RTH) is caused by mutations in the thyroid hormone receptor β gene (THRB). The syndrome varies from asymptomatic to diffuse hypothyroidism, to pituitary-selective resistance with predominance of ...
Cochran Craig, Liu Hong, Congedo Valentina, Alberobello Anna, Skarulis Monica C, Forrest Douglas, Celi Francesco S   +6 more
doaj   +1 more source

Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms-3

, 2011
β as computed from molecular dynamics simulations.Copyright information:Taken from "Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms"http://www.biomedcentral.com/1472-6807/8/8BMC Structural Biology 2008;8():8-8.Published online ...
Luiz A Simeoni (89399), Fabio M Nunes (89391), Leandro Martínez (79928), Igor Polikarpov (89402), Francisco AR Neves (89398), Rosangela da Silva (89396), Ricardo Aparicio (89390), Paulo Marcos Donate (89397), Walter H Venturelli (89395), Paul Webb (66473), Lucas Bleicher (89389), Sandra M Gomes Dias (89392), Munir S Skaf (89401), Ana Carolina Migliorini Figueira (89393), Maria Auxiliadora Morim Santos (89394), John D Baxter (89400)   +15 more
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Dietary Dityrosine Impairs Glucose Homeostasis by Disrupting Thyroid Hormone Signaling in Pancreatic β-Cells

Foods
Growing evidence links processed red meat consumption to increased diabetes risk, with oxidized proteins and/or amino acids proposed as potential mediators. We investigated whether dityrosine (Dityr), a key oxidation biomarker in high-oxidative pork (HOP)
Yueting Ge, Boyang Kou, Chunyu Zhang, Chengjia Gu, Lin Cheng, Yonghui Shi, Guowei Le, Wei Xu   +7 more
doaj   +1 more source

Effect of Aqueous Extract of Foeniculum Vulgare on Thyroid Hormones and the Expression of its Receptors in the Ovaries of BALB/C Mice [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Fennel (Foeniculum vulgare) is one of the ancient plants that has various medicinal effects. The main hormones produced by the thyroid gland are thyroxine (T4) and triiodothyronine (T3), which regulate the body's growth and ...
Fatemeh Javadi, Monireh Movahedi, mahmood Barati, Seyedeh Masoomeh Amiri, Lida Kooshesh, Fereshteh Golab   +5 more
doaj  

Synthetic Thyroid Hormone Receptor-β Agonists Promote Oligodendrocyte Precursor Cell Differentiation in the Presence of Inflammatory Challenges. [PDF]

Pharmaceuticals (Basel), 2023
Baldassarro VA, Quadalti C, Runfola M, Manera C, Rapposelli S, Calzà L.   +5 more
europepmc   +1 more source

Discovery of a novel, liver-targeted thyroid hormone receptor-β agonist, CS271011, in the treatment of lipid metabolism disorders. [PDF]

Front Endocrinol (Lausanne), 2023
Lin S, Huang S, Deng Z, Zhang Y, Huang L, Wu Y, Lv S, Wang Z, Huang N, Wang L, Chen Z, Yu G, Yin W, Zhou Y, Fang Z.   +14 more
europepmc   +1 more source

Thyroid Stimulating Hormone Receptor

, 2017
Thyroid stimulating hormone receptor (TSHR) plays a pivotal role in thyroid hormone metabolism. It is a major controller of thyroid cell function and growth. Mutations in TSHR may lead to several thyroid diseases, most commonly hyperthyroidism.
Tuncel, Murat
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