Thyroid hormone regulation of gene expression in primary cerebrocortical cells: role of thyroid hormone receptor subtypes and interactions with retinoic acid and glucocorticoids. [PDF]
PLoS ONE, 2014 The effects of thyroid hormone on brain development and function are largely mediated by the binding of 3,5,3'-triiodo-L-thyronine (T3) to its nuclear receptors (TR) to regulate positively or negatively gene expression.
Pilar Gil-Ibáñez +2 more
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Bisphenols and Thyroid Hormone [PDF]
Endocrinology and Metabolism, 2019 In recent decades, attention has been directed toward the effects of bisphenol A (BPA) on human health. BPA has estrogenic activity and is regarded as a representative endocrine disruptor.
Min Joo Kim, Young Joo Park
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Thyroid Hormone Receptor [PDF]
Definitions, 2020 The thyroid hormone receptor (THR) is a type of nuclear receptor which belongs to a superfamily of eukaryotic transcription factors. It regulates gene expression in response to binding small, hydrophobic ligands.
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Selenium, Iodine and Iron–Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism
International Journal of Molecular Sciences, 2023 The adequate availability and metabolism of three essential trace elements, iodine, selenium and iron, provide the basic requirements for the function and action of the thyroid hormone system in humans, vertebrate animals and their evolutionary ...
J. Köhrle
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Frontiers in Medicine, 2020 Thyroid hormones (THs) elicit significant effects on numerous physiological processes, such as growth, development, and metabolism. A lack of thyroid hormones is not compatible with normal health.
F. Saponaro +4 more
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Thyroid Hormone Resistance in a Preterm Infant with a Novel THRB Mutation [PDF]
Neonatal Medicine, 2019 Resistance to thyroid hormone (RTH) is a condition caused by a mutation in the thyroid hormone receptor gene. It is rarely reported in individuals with no family history of RTH or in premature infants, and its clinical presentation varies. In our case, a
Joon Yeol Bae +6 more
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Thyroid disruption by Di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) in Xenopus laevis. [PDF]
PLoS ONE, 2011 BACKGROUND: Di-n-butyl phthalate (DBP), a chemical widely used in many consumer products, is estrogenic and capable of producing seriously reproductive and developmental effects in laboratory animals.
Ouxi Shen +13 more
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Central hyperthyroidism combined with Graves' disease: case series and review of the literature
European Thyroid Journal, 2023 Background: Central hyperthyroidism is characterized by elevated free thyroid hormone and unsuppressed thyroid-stimulating hormone (TSH), and this laboratory feature includes TSH-secreting pituitary adenoma (TSHoma) and resistance to thyroid hormone β ...
Caiyan Mo +4 more
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Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance
Endocrine Connections, 2022 Background: Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α, β) with differential tissue distribution. Thyroid hormone recepto r β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly ...
Marcus Heldmann +11 more
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Resistance to thyroid hormone due to a novel mutation of thyroid hormone receptor beta gene [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2014 Resistance to thyroid hormone (RTH) is a rare inherited syndrome characterized by diminished response of the target tissue to thyroid hormone caused, in the majority of cases, by mutation of the thyroid hormone receptor beta (THRβ) gene. Despite elevated
Jae Hee Lee, Eun Young Kim
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