Thyroid hormone, thyroid hormone receptors, and cancer: a clinical perspective [PDF]
Endocrine-Related Cancer, 2013 Abstract Thyroid hormones (THs) may play a role in diseases other than hyper- and hypothyroidism. Several lines of evidence suggest tumor-promoting effects of TH and TH receptors. They are possibly mediated by phosphatidylinositol-3-kinase and MAPK and involve among others stimulation of angiogenesis via αvβ3.
Möller, Lars, Führer, Dagmar
openaire +3 more sources
Nature Communications, 2022 Thyroid hormones regulate systemic glucose metabolism through incompletely understood mechanisms. Here the authors report that hepatic thyroid hormone receptor β mediates the effects of the thyroid hormone T3 on systemic glucose homeostasis by modulating
Ying Yan +20 more
doaj +1 more source
Variation in the Thyrotropic Activity of Human Chorionic Gonadotropin in Chinese Hamster Ovary Cells Arises from Differential Expression of the Human Thyrotropin Receptor and Microheterogeneity of the Hormone. [PDF]
, 1995 The role of hCG as a stimulator of the human thyroid has been a subject of controversy, because discrepant results have been obtained in different in vitro assays.
Mann, K. +4 more
core +1 more source
Longitudinal evidence of the impact of normal thyroid stimulating hormone variations on cognitive functioning in very old age [PDF]
, 2008 The purpose of this study was to examine longitudinal associations among thyroid stimulating hormone (TSH) levels and cognitive performance. Data collected at the first three assessment times, approximately 3 years apart, are reported for the survivors ...
Wahlin, TBR, Wahlin, A, Bunce, D
core +3 more sources
Can increased prenatal exposure to thyroid hormones alter physiology and behaviour in the long-term? Insights from an experimental study in Japanese quails [PDF]
PeerJMaternal thyroid hormones (triiodothyronine T3 and thyroxine T4) are important regulators of embryonic development and gene expression. In chickens, prenatal thyroid hormone treatment has been shown to influence embryonic gene expression and postnatal ...
Kalle Aho +4 more
doaj +2 more sources
Interaction of Human Chorionic Gonadotropin (hCG) and Asialo-hCG with Recombinant Human Thyrotropin Receptor. [PDF]
, 1994 hCG is a putative thyroid stimulator. The present studies were undertaken to examine its interaction and that of its desialylated variant asialo-hCG with recombinant human TSH (hTSH) receptor (hTSHr). To this end, we transfected a human thyroid carcinoma
Mann, K. +4 more
core +1 more source
TSHR (thyroid stimulating hormone receptor). [PDF]
, 2009 TSHR (Thyroid Stimulating Hormone Receptor) gene DNA: position, structure, transcription Protein: structure, expression, localization, function Mutations: somatic and germinal mutations Disease/oncogenesis: Thyroid adenoma, Toxic multinodular goiter (
IOSCO, CARMELA, RHODEN, KERRY JANE
core +2 more sources
Methods to assess iron and iodine status [PDF]
, 2008 Four methods are recommended for assessment of iodine nutrition: urinary iodine concentration, the goitre rate, and blood concentrations of thyroid stimulating hormone and thyroglobulin.
Zimmermann, Michael B. +2 more
core +1 more source
A Novel Role for Thyroid Hormone Receptor Beta in Cellular Radiosensitivity [PDF]
, 2008 Thyroid hormone receptors (THRs) widely govern cell growth, differentiation and metabolism acting in a ligand- and cofactor-dependent manner to modulate tissue-specific gene expression. Given a large variety of genes regulated by THRs and multiplicity of
Hiroyuki NAMBA +17 more
core +1 more source
Thyroid Hormone Regulates the mRNA Expression of Small Heterodimer Partner through Liver Receptor Homolog-1 [PDF]
Endocrinology and Metabolism, 2015 BackgroundExpression of hepatic cholesterol 7α-hydroxylase (CYP7A1) is negatively regulated by orphan nuclear receptor small heterodimer partner (SHP).
Hwa Young Ahn +10 more
doaj +1 more source