Results 11 to 20 of about 1,914,121 (297)

Thyroid Stimulating Hormone Receptor

Molecular Imaging and Radionuclide Therapy, 2017
Thyroid stimulating hormone receptor (TSHR) plays a pivotal role in thyroid hormone metabolism. It is a major controller of thyroid cell function and growth. Mutations in TSHR may lead to several thyroid diseases, most commonly hyperthyroidism. Although its genetic and epigenetic alterations do not directly lead to carcinogenesis, it has a crucial role
Tuncel, Murat
openaire   +3 more sources

Thyroid hormone resistance: a novel mutation in thyroid hormone receptor beta (THRB) gene - case report [PDF]

The Turkish Journal of Pediatrics, 2013
Thyroid hormone resistance (THR) is a dominantly inherited syndrome characterized by reduced sensitivity to thyroid hormones. It is usually caused by mutations in the thyroid hormone receptor beta (THRB) gene.
Emregül Işık, Paolo Beck Peccoz, Irene Campi, Alev Özön, Ayfer Alikaşifoğlu, Nazlı Gönç, Nurgün Kandemir   +6 more
doaj   +4 more sources

Hormone Selectivity in Thyroid Hormone Receptors [PDF]

Molecular Endocrinology, 2001
Separate genes encode thyroid hormone receptor subtypes TRalpha (NR1A1) and TRbeta (NR1A2). Products from each of these contribute to hormone action, but the subtypes differ in tissue distribution and physiological response. Compounds that discriminate between these subtypes in vivo may be useful in treating important medical problems such as obesity ...
R L, Wagner, B R, Huber, A K, Shiau, A, Kelly, S T, Cunha Lima, T S, Scanlan, J W, Apriletti, J D, Baxter, B L, West, R J, Fletterick   +9 more
openaire   +2 more sources

Thyroid hormone receptors and resistance to thyroid hormone disorders [PDF]

Nature Reviews Endocrinology, 2014
Thyroid hormone action is predominantly mediated by thyroid hormone receptors (THRs), which are encoded by the thyroid hormone receptor α (THRA) and thyroid hormone receptor β (THRB) genes. Patients with mutations in THRB present with resistance to thyroid hormone β (RTHβ), which is a disorder characterized by elevated levels of thyroid hormone, normal
Tânia M, Ortiga-Carvalho, Aniket R, Sidhaye, Fredric E, Wondisford   +2 more
openaire   +2 more sources

Thyroid hormone receptors and cancer [PDF]

Biochimica et Biophysica Acta (BBA) - General Subjects, 2013
Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the actions of the thyroid hormone (T3) in development, growth, and differentiation. The THRA and THRB genes encode several TR isoforms that express in a tissue- and development-dependent manner.
Won Gu, Kim, Sheue-yann, Cheng
openaire   +2 more sources

Central hyperthyroidism combined with Graves' disease: case series and review of the literature

European Thyroid Journal, 2023
Background: Central hyperthyroidism is characterized by elevated free thyroid hormone and unsuppressed thyroid-stimulating hormone (TSH), and this laboratory feature includes TSH-secreting pituitary adenoma (TSHoma) and resistance to thyroid hormone β ...
Caiyan Mo, Han Chen, Qi Zhang, Ying Guo, Liyong Zhong   +4 more
doaj   +1 more source

Reduced pituitary size in subjects with mutations in the THRB gene and thyroid hormone resistance

Endocrine Connections, 2022
Background: Thyroid hormone action is mediated by two forms of thyroid hormone receptors (α, β) with differential tissue distribution. Thyroid hormone recepto r β (TRβ) mutations lead to resistance to thyroid hormone action in tissues predominantly ...
Marcus Heldmann, Krishna Chatterjee, Carla Moran, Berenike Rogge, Julia Steinhardt, Tobias Wagner-Altendorf, Martin Göttlich, Hannes Schacht, Peter Schramm, Georg Brabant, Thomas F Münte, Anna Cirkel   +11 more
doaj   +1 more source

Resistance to thyroid hormone due to a novel mutation of thyroid hormone receptor beta gene [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2014
Resistance to thyroid hormone (RTH) is a rare inherited syndrome characterized by diminished response of the target tissue to thyroid hormone caused, in the majority of cases, by mutation of the thyroid hormone receptor beta (THRβ) gene. Despite elevated
Jae Hee Lee, Eun Young Kim
doaj   +1 more source

Cooperative Subtype Switch of Thyroid Hormone Receptor and Nuclear Receptor Corepressor Related Epithelial–Mesenchymal Transition in Papillary Thyroid Cancer [PDF]

, 2021
Background and Objectives: Although thyroid hormones affect human cancer progression, the regulatory mechanism of thyroid hormone receptors in carcinogenesis has not been elucidated.
이잔디, 김인규, 조영석, 박선미, 이기쁨, Hyunji Kim, Jandee Lee, Seul Gi Lee, Young Suk Jo, In-Kyu Kim, Seonhyang Jeong, Sunmi Park, Gibbeum Lee   +12 more
core   +1 more source

Changes in Clinical Activity, Serum Autoantibody Levels, and Chorioretinal Vessels After Systemic Glucocorticoid Therapy in Thyroid Eye Disease

Ophthalmology and Therapy, 2023
Introduction The aim of this study was to investigate changes in the Clinical Activity Score, serum thyroid-stimulating hormone receptor antibody and thyroid-stimulating immunoglobulin levels, chorioretinal blood vessels, and extraocular muscle thickness
Jaekyoung Lee, Dong Cheol Lee
doaj   +1 more source