Results 101 to 110 of about 2,507,137 (250)

Discovery of a novel, liver-targeted thyroid hormone receptor-β agonist, CS271011, in the treatment of lipid metabolism disorders. [PDF]

Front Endocrinol (Lausanne), 2023
Lin S, Huang S, Deng Z, Zhang Y, Huang L, Wu Y, Lv S, Wang Z, Huang N, Wang L, Chen Z, Yu G, Yin W, Zhou Y, Fang Z.   +14 more
europepmc   +1 more source

Steroid Hormones and Endocrine Disruptors: Recent Advances in Receptor–Mediated Actions [PDF]

, 2001
It has been accepted that receptor-mediated action of steroid hormones depends on both the receptor and the hormonal level. The mechanism of transcription by steroid receptors is mediated by cofactors, which function as co-activators or co-repressors,
Indarto, Dono, Izawa, Masao
core  

Antigen receptor variable region repertoires expressed by T cells infiltrating thyroid, retroorbital, and pretibial tissue in Graves' disease [PDF]

, 1996
To date, it has remained unclear whether T cells infiltrating thyroid, retroorbital, and pretibial tissue of patients with Graves' ophthalmopathy and pretibial dermopathy represent a primary immune response that is directed against certain antigenic ...
Wenzel, Björn E., Heufelder, Armin E., Scriba, Peter C.   +2 more
core   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Regulation of cancer stem cell activity by thyroid hormone receptor β. [PDF]

Oncogene, 2022
Doolittle WKL, Zhu X, Park S, Zhu YJ, Zhao L, Meltzer P, Cheng SY.   +6 more
europepmc   +1 more source

Efeito do T3 reverso sobre o estresse oxidativo induzido pelo hipotireoidismo congênito em hipocampo de ratos imaturos: envolvimento de mecanismos não genômicos [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014.Abstract : Congenital hypothyroidism can lead to a variety of neurochemical and morphophysiological ...
Domingues, Juliana Tonietto
core  

Thyroid hormone receptor alpha(1) regulates expression of the na+/H+ exchanger (NHE1)

, 2002
In this paper we examine the role of thyroid hormone in regulating expression of the Na+/H+ exchanger. Thyroid hormone has been reported to regulate the activity of the Na+/H+ exchanger messenger RNA in some cell types. Treatment of cardiac myocytes with
Rieder, Carmen V., Misik, Angelika J., Li, Xiuju J., Fliegel, Larry, Solaro, R. John, Lowen, Anice   +5 more
core   +1 more source

The receptor tyrosine kinase RET is a Hsp90 client protein and is degraded upon exposure to 17-AAG. [PDF]

, 2009
Molecular alterations of the receptor tyrosin kinase RET are involved in the pathogenesis of thyroid cancer. Germline point mutations in the extracellular and intracellular domains of the receptor are responsible of a group of inherited cancer diseases ...
Alfano, Luigi
core   +1 more source

LXRα and PPARα Mediated Hepatic Lipid Metabolic Disruption Induced by the UV Filter EHMC in 2D and 3D HepaRG Cell Models

Food Safety and Health, EarlyView.
Dietary UV filter EHMC induces hepatic steatosis in HepaRG cells at noncytotoxic concentrations. Mechanistically, EHMC binds nuclear receptors (LXRα, PPARα), upregulating SREBP‐1 to accelerate fatty acid synthesis. These findings highlight the potential metabolic toxicity of widespread EHMC exposure through food sources.
Shanglin Yang, Na Li, Yingnan Han, Mei Ma   +3 more
wiley   +1 more source

TG68, a Novel Thyroid Hormone Receptor-β Agonist for the Treatment of NAFLD. [PDF]

Int J Mol Sci, 2021
Caddeo A, Kowalik MA, Serra M, Runfola M, Bacci A, Rapposelli S, Columbano A, Perra A.   +7 more
europepmc   +1 more source