Results 131 to 140 of about 42,240 (230)

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Brain and Cardiometabolic Effects of Major Weight Loss in People With Obesity: Preliminary Cohort Findings

Obesity Science &Practice, Volume 12, Issue 6, December 2026.
ABSTRACT Objective Given the overlap between obesity‐related metabolic and vascular abnormalities and Alzheimer's disease (AD) risk factors, it is critical to determine whether weight loss improves brain and cardiovascular health. This study examined whether ≥ 40% excess‐weight loss is associated with improvements in cardiometabolic risk, brain ...
Naomi L. Gaggi, Brian Hurwitz, Jennifer Bernal, Courtney O'Brien, Christine Ren‐Fielding, Holly Lofton, Jenny Chen, Aviezer Saperstein, Sang Han Lee, Yun‐Juan Chang, Kathy F. Yates, Els Fieremans, Ricardo Osorio, Antonio Convit   +13 more
wiley   +1 more source

The syndrome of resistance to thyroid stimulating hormone.

Journal of the Chinese Medical Association : JCMA, 2004
Resistance to thyroid stimulating hormone (TSH) is a syndrome of reduced sensitivity to a biologically active TSH molecule. Subjects have elevated TSH levels but no goiter. However, thyroid hormone concentration may vary from normal to very high, depending on the severity of the resistance.
openaire   +1 more source

Network based approach identifies miR‐145‐3p as a central regulatory hub associated to the progression from localized to metastatic medullary thyroid carcinoma

The Journal of Pathology, Volume 270, Issue 4, Page 468-480, December 2026.
Abstract Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor originating from calcitonin producing C‐cells and accounts for 1–5% of thyroid cancers. Total thyroidectomy is curative in localized disease (N0), whereas lymph node metastases (N1) are associated with poorer prognosis.
Anna Citarella, Manuela Petti, Zein Mersini Besharat, Caterina Alfano, Elena Splendiani, Sofia Trocchianesi, Sara Cassandro, Martina Chiacchiarini, Claudia Sabato, Francesca Gianno, Tanja Milena Autilio, Martina Brunetti, Giuseppina Catanzaro, Antonella Verrienti, Rossella Elisei, Raffaele Ciampi, Cristina Romei, Maria Grazia Castagna, Silvia Cantara, Vincenzo Marotta, Luciano Pezzullo, Lorenzo Farina, Cosimo Durante, Agnese Po, Elisabetta Ferretti   +24 more
wiley   +1 more source

Psychotic depression associated with Graves' disease: A case report on treatment prioritization

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 4, December 2026.
Abstract Background Graves' disease can be accompanied by psychiatric symptoms, including affective and psychotic manifestations. When a well‐defined psychiatric syndrome occurs concurrently with a medical illness, determining whether it is directly attributable to the medical condition or represents an independent psychiatric disorder precipitated by ...
Ayumu Kocha, Aya Akaba, Nozomi Sawasaki, Shinobu Seno, Naoya Hara, Taro Minato, Atsuo Nakagawa, Hiroki Kocha   +7 more
wiley   +1 more source

Self‐Reported Health Problems of Birthing Persons During the First and Second Postpartum Years: Scope and Correlates

Birth, Volume 53, Issue 4, Page 795-805, December 2026.
ABSTRACT Background Postpartum health‐related problems are diverse, and some may extend beyond the first postpartum year. The purpose of this study was to describe women's postpartum health problems in the first and second postpartum years. Methods We analyzed data from an online survey (N = 427) conducted in 2024.
Sudhathai Sirithepmontree, Lina Palomares, Lorraine O. Walker   +2 more
wiley   +1 more source

A Case with Thyroid Hormone Resistance Syndrome [PDF]

Soonchunhyang Medical Science, 2018
HanByul Lee, Jeongho Lee, Dong Hwan Lee
openaire   +1 more source

A New Case of Lethal Congenital Contracture Syndrome Type 3 With Hyperinsulinism and Optic Atrophy

Clinical Genetics, Volume 110, Issue 6, Page 736-741, December 2026.
PIP5K1C‐related lethal congenital contracture syndrome with hyperinsulinism and optic atrophy. ABSTRACT Lethal congenital contracture syndrome 3 (LCCS3, MIM #611369) is a rare autosomal recessive neuromuscular disorder caused by biallelic loss‐of‐function (LOF) variants in PIP5K1C, reported in only two families to date.
Tameemi Abdalla Moady, Hadar Hulin Ma'ayan, Michal Cohen, Karin Weiss   +3 more
wiley   +1 more source

Hypothalamic Neurochemical and Microglial Suppression in Long‐Standing Human Hibernation‐Like Syndrome

Neuropathology and Applied Neurobiology, Volume 52, Issue 6, December 2026.
A rare case of a human hibernation‐like syndrome was associated with preserved hypothalamic anatomy but profound suppression of neuroendocrine and circadian neuropeptide systems. Marked reductions in synaptic and microglial immunoreactivity suggest a suppressed hypothalamic neuron–glial network, despite preserved astrocytic markers, myelination and ...
Wei Jiang, Andries Kalsbeek, Roelof A. Hut, Dick F. Swaab, Chun‐Xia Yi   +4 more
wiley   +1 more source

Real‐Time Neurochemical Sensing in Zebrafish: Electrochemical and Fluorescent Approaches

Analysis &Sensing, Volume 6, Issue 6, November 2026.
The use of zebrafish has emerged as a powerful approach for real‐time neurochemical measurements. This review highlights recent advances in electrochemical and fluorescent sensing strategies that enable dynamic measurements in live preparations of this complex vertebrate. These complementary approaches provide new insights into neurochemical signaling,
Piyanka Hettiarachchi, Jacob T. Theismann, Michael A. Johnson   +2 more
wiley   +1 more source