Results 61 to 70 of about 181,112 (307)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Measurement of salivary thyroid hormones using the LC-MS/MS technique in a clinical setting

Therapeutic Advances in Endocrinology and Metabolism
Background: Saliva could be an attractive alternative to blood for assessing thyroid hormonal function. Objectives: Our goal was to determine if the levels of thyroid hormones in saliva can accurately reflect a person’s thyroid status and if they ...
Nadia Sawicka-Gutaj, Piotr Glinicki, Kacper Nijakowski, Barbara Bromińska, Magdalena Ostrowska, Alicja Szatko, Zuzanna Sobol, Konrad Kowalski, Paweł Wilk, Wojciech Zgliczyński, Marek Ruchała   +10 more
doaj   +1 more source

Thyroid Disorders and Chronic Kidney Disease

International Journal of Nephrology, 2014
Thyroid hormones play a very important role regulating metabolism, development, protein synthesis, and influencing other hormone functions. The two main hormones produced by the thyroid are triiodothyronine (T3) and thyroxine (T4).
Mohamed Mohamedali, Srikanth Reddy Maddika, Anix Vyas, Viswanathan Iyer, Pramil Cheriyath   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Thyroid dysfunction in the ageing patient

Mìžnarodnij Endokrinologìčnij Žurnal
Thyroid dysfunction is a common endocrine disorder in the general population, with a reported prevalence of 10–15 %. This rate is higher in older adults, with an estimated prevalence of 25 % in some populations.
O.V. Bilookyi, V.L. Vasiuk, O.A. Shupik
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts [PDF]

, 2013
The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes.
A Mansukhani, AK Coussens, BD Stamper, BK Huang, BU Ang, C Owen, C Yao, CB Harvey, CH Shackleton, CW Li, D Gomez, D Johnson, DC Robinson, DP Rice, DT Gault, G Radetti, G Ramajayam, GA Brent, GM Morriss-Kay, GR Williams, H Kohara, H Miraoui, HJ Kim, J Connerney, J Esparza, J Zumbrunn, JA Greenwald, Jack C. Yu, James J. Cray, JH Bassett, JH Oh, JL Penfold, JM Britto, JQ Feng, JS Morey, K Kasono, KA Kapp-Simon, Kameron Khaksarfard, KM Lee, M Bodo, M Menking, M Segni, MH Sheng, MM Cohen Jr, Mohammed Elsalanty, PJ Marie, R Rice, S Akita, S Wadhwa, S Weiss, SA Boyadjiev, SA Rasmussen, Seth M. Weinberg, W Arlt, W Riggs Jr, WM Chadduck, Xing-Ming Shi, Y Xiong, Z von Marschall   +58 more
core   +6 more sources

Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study

Environment International, 2018
Background: Few epidemiological studies have investigated associations of exposure to multiple metals with thyroid hormone homeostasis, especially for the pregnant women.
Jing Guo, Na Lv, Jun Tang, Xue Zhang, Lihe Peng, Xiaofu Du, Shuai Li, Qiong Luo, Dan Zhang, Guangdi Chen   +9 more
doaj   +1 more source

Thyroid hormone, thyroid hormone receptors, and cancer: a clinical perspective [PDF]

Endocrine-Related Cancer, 2013
Thyroid hormones (THs) may play a role in diseases other than hyper- and hypothyroidism. Several lines of evidence suggest tumor-promoting effects of TH and TH receptors. They are possibly mediated by phosphatidylinositol-3-kinase and MAPK and involve among others stimulation of angiogenesis via αvβ3.
Möller, Lars, Führer, Dagmar
openaire   +3 more sources

Transcriptomics reveal an integrative role for maternal thyroid hormones during zebrafish embryogenesis [PDF]

, 2017
Thyroid hormones (THs) are essential for embryonic brain development but the genetic mechanisms involved in the action of maternal THs (MTHs) are still largely unknown.
A Tallafuss, AC Lekven, AC Lekven, ALS Dowling, AP Halestrap, AV Gore, B Langmead, C Schuurmans, C Trapnell, CB Kimmel, CC Thompson, CM Armour, D Croft, D Lopez-Espindola, D Zada, DM Power, E Vrieze de, ECH Friesema, ECH Friesema, ECH Friesema, F Boukhtouche, F Chatonnet, F Chatonnet, F Supek, FJ Arjona, GD Vatine, GO Consortium, GR Williams, H Dong, H Gao, H Heuer, H Iwayama, J Bernal, J Chang, J Delbaere, J Jin, J Patel, J Schindelin, JJ Essner, JJ Essner, K Wallis, KR Holden, L Boccone, LA Desouza, MA Campinho, MA Campinho, MD Robinson, MF Batista, PC Holm, RB MacDonald, RS Dezonne, RT Zoeller, RT Zoeller, S Bertrand, S Horn, S Kersseboom, S Mayerl, S Skah, S-X Wu, T Pierfelice, VM Darras, VW Edward, Y Katsuyama, Y-C Cheng   +63 more
core   +2 more sources