Results 61 to 70 of about 449,550 (308)

Measurement of salivary thyroid hormones using the LC-MS/MS technique in a clinical setting

Therapeutic Advances in Endocrinology and Metabolism
Background: Saliva could be an attractive alternative to blood for assessing thyroid hormonal function. Objectives: Our goal was to determine if the levels of thyroid hormones in saliva can accurately reflect a person’s thyroid status and if they ...
Nadia Sawicka-Gutaj, Piotr Glinicki, Kacper Nijakowski, Barbara Bromińska, Magdalena Ostrowska, Alicja Szatko, Zuzanna Sobol, Konrad Kowalski, Paweł Wilk, Wojciech Zgliczyński, Marek Ruchała   +10 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study

Environment International, 2018
Background: Few epidemiological studies have investigated associations of exposure to multiple metals with thyroid hormone homeostasis, especially for the pregnant women.
Jing Guo, Na Lv, Jun Tang, Xue Zhang, Lihe Peng, Xiaofu Du, Shuai Li, Qiong Luo, Dan Zhang, Guangdi Chen   +9 more
doaj   +1 more source

THE ACTION OF THYROID HORMONE [PDF]

Clinical Endocrinology, 1977
SUMMARYThyroid hormone affects both developmental and metabolic processes. It has a relatively specific effect on the synthesis of a number of enzymes and other proteins. The fundamental cellular mechanism of action seems to be at the level of genetic regulation.
J, Bernal, S, Refetoff
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The zebrafish model to identify new genes involved in thyroid development [PDF]

, 2010
Thyroid organogenesis is a very complex developmental process that leads to the formation of an organ able to produce specific hormones through specification, migration, structural organization and functional differentiation of thyroid precursor cells ...
Porreca, Immacolata
core   +1 more source

The Relation-Ship Between Anti-Thyroidal Peroxidise Antibodies (TPO-Abs) and Thyroid Hormones (T3, T4 and Thyroid Stimulating Hormone TSH) among Patients of Autoimmune Thyroid Disease (AITD).

Kufa Journal for Nursing Sciences, 2014
Objectives: This Study was designed to investigate the role of the auto antibodies against thyroid peroxidise (TPO-Abs) and thyroid Hormones (T3, T4, TSH) in pathogenesis of Autoimmune Thyroid Disease (AITD).
Hashim Rahim Taresh, Rawaa Behlul Majhul Al-Fatlawi, Salman Aziz Al-Juburi   +2 more
doaj   +1 more source

Thyroid Gene Mutations in Pregnant and Breastfeeding Women Diagnosed With Transient Congenital Hypothyroidism: Implications for the Offspring’s Health

Frontiers in Endocrinology, 2021
Fetus and infants require appropriate thyroid hormone levels and iodine during pregnancy and lactation. Nature endorses the mother to supply thyroid hormones to the fetus and iodine to the lactating infant.
Maria C. Opazo, Maria C. Opazo, Juan Carlos Rivera, Pablo A. Gonzalez, Susan M. Bueno, Alexis M. Kalergis, Alexis M. Kalergis, Claudia A. Riedel   +7 more
doaj   +1 more source

Impact of Thyroid Hormones on Serum Prostate Specific Antigen Level in Patients with Benign Thyroid Disorders

, 2020
Objective:The aim of the present study was to evaluate whether thyroid hormone levels in benign thyroid disorders resulting in hypothyroidism or hyperthyroidism had an impact on the levels of serum prostate specific antigen (PSA).Materials and Methods:A ...
Yılmaz Aslan, Altuğ Tuncel, Çağdaş Şenel, Merve Çatak, Serdar Güler, Dilek Berker, Melih Balcı   +6 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source