Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update [PDF]
MetabolitesThyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food intake is not well understood.
Yamili Vargas +5 more
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The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target? [PDF]
Frontiers in Pharmacology, 2020 Thyrotropin releasing hormone (TRH: Glp-His-Pro-NH2) is a peptide mainly produced by brain neurons. In mammals, hypophysiotropic TRH neurons of the paraventricular nucleus of the hypothalamus integrate metabolic information and drive the secretion of ...
Jean-Louis Charli +6 more
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Efficiency of CIN2+ Detection by Thyrotropin-Releasing Hormone (TRH) Site-Specific Methylation [PDF]
Viruses, 2023 Cervical cancer screening typically involves a Pap smear combined with high-risk human papillomavirus (hr-HPV) detection. Women with hr-HPV positivity but normal cytology, as well as those with precancerous abnormal cytology, such as low-grade squamous ...
Arkom Chaiwongkot +4 more
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GATA2 mediates thyrotropin-releasing hormone-induced transcriptional activation of the thyrotropin β gene. [PDF]
PLoS ONE, 2011 Thyrotropin-releasing hormone (TRH) activates not only the secretion of thyrotropin (TSH) but also the transcription of TSHβ and α-glycoprotein (αGSU) subunit genes.
Kenji Ohba +9 more
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Repeatability of a thyrotropin‐releasing hormone stimulation test for diagnosis of pituitary pars intermedia dysfunction in mature horses [PDF]
Journal of Veterinary Internal Medicine, 2021 Background Pituitary pars intermedia dysfunction (PPID) is a common endocrinopathy of horses diagnosed with a thyrotropin‐releasing hormone (TRH) stimulation test.
Yan Ning Kam +3 more
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Characterization of a novel thyrotropin-releasing hormone receptor, TRHR3, in chickens [PDF]
Poultry Science, 2020 The physiological roles of thyrotropin-releasing hormone (TRH) are proposed to be mediated by TRH receptors (TRHR), which have been divided into 3 subtypes, namely, TRHR1, TRHR2, and TRHR3, in vertebrates.
Xiaoxiao Li +5 more
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Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach [PDF]
Pharmaceutics, 2019 Using thyrotropin-releasing hormone (TRH) as a model, we explored whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery ...
Katalin Prokai-Tatrai +5 more
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Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries [PDF]
Frontiers in Endocrinology, 2019 Central and peripheral mechanisms that modulate energy intake, partition and expenditure determine energy homeostasis. Thyroid hormones (TH) regulate energy expenditure through the control of basal metabolic rate and thermogenesis; they also modulate ...
Adair Rodríguez-Rodríguez +6 more
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Cardiovascular pharmacology of thyrotropin releasing hormone [PDF]
Peptides, 1988 Thyrotropin releasing hormone (TRH) and its receptors are present in the cardiovascular nuclei of the brain as well as in the intermediolateral cell column of spinal cord. Anatomical, neurophysiological, functional and pharmacological studies suggest that TRH is a neurotransmitter/neuromodulator in the central nervous system.
Sirén, Anna-Leena
openaire +4 more sources
Molecular basis for the activation of thyrotropin-releasing hormone receptor [PDF]
Cell Discovery, 2022 Su-Yu Ji +13 more
doaj +2 more sources