Results 91 to 100 of about 29,678 (279)

Design of Experiments (DoE)‐Optimized Polymeric Oxytocin Nanoparticles for Enhanced Nose‐to‐Brain Delivery

open access: yesSmall, Volume 22, Issue 8, 6 February 2026.
Intranasal (IN) delivery of PEGylated PLGA nanoparticles (NPs) loaded with oxytocin (OT) (OT‐NP‐PEG) is investigated as a strategy to enhance OT transport to the brain for treating autism and other neuropsychiatric disorders. The optimized NP formulation demonstrates appropriate physicochemical characteristics, improved stability, and enhanced mucosal ...
Naveed Ahmad   +11 more
wiley   +1 more source

Exploring tear fluid biomarkers and the ocular surface in thyroid eye disease

open access: yesActa Ophthalmologica, Volume 104, Issue 1, Page e28-e38, February 2026.
Abstract Purpose To examine ocular surface changes and inflammatory tear fluid biomarkers in patients with thyroid eye disease (TED). Methods We included 106 Graves' disease (GD) patients (36 without TED, 32 with active and 38 with inactive TED) and 106 age‐ and sex‐matched healthy subjects for ophthalmological evaluation, including ocular surface ...
Mikael Thomassen Neset   +13 more
wiley   +1 more source

Role of thyrotropin-releasing hormone test in re-evaluation of congenital hypothyroidism

open access: yesKaohsiung Journal of Medical Sciences, 2014
The thyrotropin-releasing hormone (TRH) test is useful for differentiating central and primary hypothyroidism, and is also valuable for diagnosing hypothyroidism. The threshold of the TRH test is usually set at 10–40 mIU/L.
Li-Min Chen   +4 more
doaj   +1 more source

Safety and efficacy of the therapy with CD4 + CD25highCD127‐T regulatory cells: When paediatric patient becomes adult

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1392-1402, February 2026.
Abstract Aim CD4 + CD25highCD127‐T regulatory cells (Tregs) remain a drug candidate for immunotherapy of type 1 diabetes. We completed three trials testing Tregs in recently diagnosed type 1 diabetes children. Here, we looked for long‐term safety and efficacy aspects important in the authorisation of this therapy.
Marta Bandura   +18 more
wiley   +1 more source

Thyrotropin-releasing hormone in cardiovascular pathophysiology

open access: yesRegulatory Peptides, 2005
Thyrotropin (TSH)-releasing hormone (TRH) also known as thyroliberin was the first of a number of peptides exerting several roles as a hormone and as a neuropeptide. Its ubiquitous distribution in the hypothalamus and in the extrahypothalamic regions and its diverse pharmacological and physiological effects are all features of its dual functions.
Garcia, Silvia Ines   +1 more
openaire   +3 more sources

Impact of glycemic variability on early detection of sudomotor dysfunction: Implications for early intervention and personalized treatment

open access: yesJournal of Diabetes Investigation, Volume 17, Issue 2, Page 301-309, February 2026.
ABSTRACT Background This study investigates the impact of glycemic variability on sudomotor dysfunction in type 2 diabetes mellitus. Methods A total of 206 type 2 diabetes mellitus patients and 34 healthy controls were included. Sweat function (SF) was assessed using electrochemical conductance of hands (HESC) and feet (FESC).
Yang Ou   +4 more
wiley   +1 more source

The challenge of pituitary hyperplasia differential diagnosis in a young girl with growth arrest

open access: yesAtti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche
Growth arrest is an alarming condition which requires precise and tempestive investigations in order to provide accurate diagnosis. Long-standing primary hypothyroidism (PHT) may rarely occur as a growth arrest as the only clinical sign at onset in ...
Aurora Lanzafame   +5 more
doaj   +1 more source

Ischemic Stroke in Hypereosinophilic Syndrome: A Clinicopathologic Study of Two Cases

open access: yesNeuropathology, Volume 46, Issue 1, February 2026.
ABSTRACT Ischemic stroke is a rare complication of hypereosinophilic syndrome (HES). Manifestations of stroke in HES have been described in the radiologic literature; however the pathologic characterization of central nervous system (CNS) involvement in HES is limited.
Karina C. Martin   +3 more
wiley   +1 more source

Whole-Exome Sequencing Study of Thyrotropin-Secreting Pituitary Adenomas [PDF]

open access: yes, 2018
学位記番号 ...
Santosh, Sapkota   +2 more
core  

Safety evaluation of the food enzyme triacylglycerol lipase from the genetically modified Trichoderma reseei strain AR‐822

open access: yesEFSA Journal, Volume 24, Issue 2, February 2026.
Abstract The food enzyme triacylglycerol lipase (triacylglycerol acylhydrolase, EC 3.1.1.3) is produced with the genetically modified Trichoderma reseei strain AR‐822 by AB Enzymes GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA.
EFSA Panel on Food Enzymes (FEZ)   +17 more
wiley   +1 more source

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