Results 111 to 120 of about 537,941 (229)

Hypothalamus Participates in Peripheral Sympathetic Hyperactivity After Acute Brain Injury by Regulating Trhr M6A Modification

MedComm, Volume 7, Issue 10, October 2026.
In acute brain injury (TBI/ICH), sympathetic hyperactivity is driven by hypothalamic FTO upregulation. FTO demethylates Trhr, blocking m6A‐YTHDF2‐dependent degradation, which stabilizes Trhr mRNA and increases neuronal sensitivity to TRH. Restoring FTO or Trhr alleviates sympathetic hyperactivity, offering a potential target for managing autonomic ...
Maoxing Fei, Handong Wang, Chaochao Gao, Shiqiao Luo, Xiwen Huang, Yanling Han, Mengliang Zhou, Zhenxing Li   +7 more
wiley   +1 more source

Demonstration of pyroglutamylpeptidase and amidase activities toward thyrotropin-releasing hormone in hamster hypothalamus extracts

, 1976
Using a radioimmunoassay method for thyrotropin-releasing hormone, the presence of thyrotropin-releasing hormone-metabolizing activity in various hamster tissues was demonstrated.
Prasad, Chandan, Peterkofsky, A.
core   +1 more source

The Diagnostic Performance of Afirma Genomic Sequencing Classifier in Black and Hispanic Patients With Indeterminate Thyroid Nodules

Otolaryngology–Head and Neck Surgery, Volume 175, Issue 4, Page 849-858, October 2026.
Abstract Objective About 20% of thyroid nodules detected on ultrasound are cytologically indeterminate (Bethesda categories III and IV), but the rate of malignancy of these nodules is less than 36%. The ability of Afirma Genomic Sequencing Classifier (GSC) to further risk‐stratify indeterminate thyroid nodules among Black and Hispanic patients is ...
Peter J. Attia, Sree Chinta, Joseph Celidonio, John Sebastian De Armas, Evelyne Kalyoussef, Dylan F. Roden   +5 more
wiley   +1 more source

Influence of the gut microbiome on appetite-regulating neuropeptides in the hypothalamus: Insight from conventional, antibiotic-treated, and germ-free mouse models of anorexia nervosa

Neurobiology of Disease
Recent research highlights the profound impact of the gut microbiome on neuropsychiatric disorders, shedding light on its potential role in shaping human behavior.
Radka Roubalová, Petra Procházková, Tereza Kovářová, Janet Ježková, Tomáš Hrnčíř, Helena Tlaskalová-Hogenová, Hana Papežová   +6 more
doaj   +1 more source

Effects of Mindfulness Therapy on Stress Biomarkers and Psychological Symptoms in Women With Recurrent Pregnancy Loss: A Randomized Clinical Trial

Stress and Health, Volume 42, Issue 5, October 2026.
ABSTRACT Women with recurrent pregnancy loss (RPL) exhibit high levels of depression, anxiety, and stress, which negatively impact their quality of life. This randomized clinical trial evaluated the effects of an eight‐week online Mindfulness‐Based Intervention (MBI), with weekly one‐hour sessions, on psychological and biological markers of stress in ...
Elaine C. F. Oliveira, Sara P. C. Paiva, Enrrico Bloise, Fernando M. Reis   +3 more
wiley   +1 more source

Activity and specificity of synthetic thyrotropin-releasing hormone in man

, 1970
The serum levels of thyrotropin (TSH) increased two minutes after a quick single iv. injection of 800 μg of synthetic thyrotropin releasing hormone (TRH) into a normal male subject. The peak elevation of TSH occurred after 30 minutes, and was 370% higher
Bowers, C.Y, Folkers, K, Schally, A.V, Gual, C, Schalch, D.S, Kastin, A.J   +5 more
core   +1 more source

The last‐step integrator thesis: Heterarchical control of the mammalian gastrointestinal tract

The Journal of Physiology, Volume 604, Issue 20, Page 8323-8344, 15 October 2026.
Abstract figure legend Heterarchy of control of the gastrointestinal tract. The production mechanisms (i.e. epithelial cells and muscles) are shown at the bottom in green. Above them are some of the many mechanisms that provide control inputs to these production mechanisms.
William Bechtel, Leonardo Bich
wiley   +1 more source

Regulation of Thyroid Hormone Levels by Hypothalamic Thyrotropin-Releasing Hormone Neurons. [PDF]

Thyroid, 2023
Costa-E-Sousa RH, Rorato R, Hollenberg AN, Vella KR.   +3 more
europepmc   +1 more source

Safety evaluation of the food enzyme cellulase from the genetically modified Trichoderma reesei strain NZYM‐FS

EFSA Journal, Volume 24, Issue 10, October 2026.
Abstract The food enzyme cellulase (4‐(1,3; 1,4)‐β‐d‐glucan‐4‐glucanohydrolase, EC 3.2.1.4) is produced with the genetically modified Trichoderma reesei strain NZYM‐FS by Novozymes A/S. The genetic modifications did not give rise to safety concerns. The food enzyme was considered free from viable cells of the production organism and its DNA.
EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Henk Van Loveren, Laurence Vernis, Cristina Andreoli, Andrea Terron, Andrey Yurkov, Ana Gomes, Daniele Cavanna, Cristina Fernández‐Fraguas, Natália Kovalkovičová, Yi Liu   +20 more
wiley   +1 more source

Structure and function of sea urchin neuropeptides [PDF]

, 2010
PhDThe subject of this thesis is the identification and functional characterization of sea urchin neuropeptides. Neuropeptides are important mediators of neural signalling in all known animals with a nervous system, including bilaterians, ctenophorans ...
Rowe, Matthew Lyndon
core   +1 more source