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Recurrent Goiter, Hyperthyroidism, Galactorrhea and Amenorrhea due to a Thyrotropin ans Prolactin-Producing Pituitary Tumor [PDF]
, 1976 Erhardt, F. +5 more
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Thyrotropin-releasing hormone in schizophrenia
American Journal of Psychiatry, 1975Oral administration of thyrotropin-releasing hormone (TRH) caused deterioration in the clinical status of seven out of nine schizophrenic men. This change was particularly apparent in the four patients diagnosed as paranoid schizophrenics. Such changes might be expected from a drug with properties similar to amphetamine.
K L, Davis, L E, Hossister, P A, Berger
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New England Journal of Medicine, 1982
The modern era of neuroendocrinology was ushered in just over a decade ago with the isolation and characterization, from ovine1 and porcine2 hypothalamic tissue, of a tripeptide (pyroglutamyl-histi...
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The modern era of neuroendocrinology was ushered in just over a decade ago with the isolation and characterization, from ovine1 and porcine2 hypothalamic tissue, of a tripeptide (pyroglutamyl-histi...
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Thyrotropin-Releasing Hormone Analogs
Mini-Reviews in Medicinal Chemistry, 2006Thyrotropin releasing hormone (TRH: pyroglutamic acid-histidine-prolineamide) regulates the activity of cells in the anterior pituitary and within the central and peripheral nervous systems. TRH, which has been the subject of much research over the past three decades, exerts its effects by acting through class A G-protein coupled receptors.
A O, Colson, M C, Gershengorn
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Organ distribution of thyrotropin-releasing hormone
General and Comparative Endocrinology, 1972Abstract The distribution of radioactivity after intravenous injection of [ 3 H]- or [ 14 C]thyrotropin-releasing hormone has been studied by whole-body autoradiography of the mouse or direct measurement of radioactivity in individual organs of the rat. Data obtained with the two different techniques and animal species are in good agreement.
A, Dupont +3 more
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A sensitive radioimmunoassay for thyrotropin releasing hormone
Clinica Chimica Acta, 1973Abstract A sensitive radioimmunoassay for TRH is described which is capable of detecting 100 pg/ml. Antibody was produced by injection of TRH coupled to bovine serum albumin by a diazonium compound (BDB). Radioiodinated TRH was purified by gel filtration chromatography.
P, May, R K, Donabedian
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Pharrnacokinetics of intrathecal thyrotropinâreleasing hormone
Neurology, 1987An investigation of the efficacy of thyrotropin-releasing hormone in amyotrophic lateral sclerosis included study of the intrathecal pharmacokinetics of this neuropeptide. Its mean elimination half-life in CSF was 0.90 hours and was monoexponential. During a 2-hour infusion, 2.75% crossed the CSF/blood-brain barrier.
T L, Munsat, J, Taft, I M, Jackson
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Journal of Animal Science, 1983
An 8-wk growth trial was conducted to assess the effects of continuous infusion of thyrotropin-releasing hormone (TRH) and an active TRH analog less than Aad-His-Pro-NH2 (the less than Aad is L-pyro-alpha-aminoadipic acid) on growth trial performance, carcass composition and hormone profiles of growing lambs. Both drugs were infused at 600 micrograms X
L A, Muir, S, Wien
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An 8-wk growth trial was conducted to assess the effects of continuous infusion of thyrotropin-releasing hormone (TRH) and an active TRH analog less than Aad-His-Pro-NH2 (the less than Aad is L-pyro-alpha-aminoadipic acid) on growth trial performance, carcass composition and hormone profiles of growing lambs. Both drugs were infused at 600 micrograms X
L A, Muir, S, Wien
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Thyrotropin-releasing hormone in the gastrointestinal tract
Biochemical and Biophysical Research Communications, 1977Abstract TRH immunoreactivity has been shown to occur throughout the rat gastrointestinal tract. This immunoreactivity demonstrates parallelism with TRH, is destroyed by fresh human serum, and co-chromatographs with TRH on a Sephadex G-10 column and on a SP Sephadex C-25 column.
J E, Morley +3 more
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