Results 61 to 70 of about 320 (154)

Evaluating the Link Between Thyroid Function Test Results and Levothyroxine Dose in the Management of Hypothyroidism: Can We Improve Dosing Regimes?

Clinical Endocrinology, Volume 104, Issue 4, Page 372-385, April 2026.
ABSTRACT Introduction Over 10 million thyroid function tests (TFTs) are carried out in England each year, most requests coming from primary care. Our previous work showed that only 25% of results for patients being treated with Levothyroxine fell within the TSH/FT4 boundary circumscribing 75% of untreated individuals.
Adrian H. Heald, Lakdasa D. Premawardhana, Peter N. Taylor, Suhani Bahl, Onyebuchi E. Okosieme, Anthony A. Fryer, Antonio Bianco, Colin M. Dayan, Michael P. Stedman   +8 more
wiley   +1 more source

Primary Hypothyroidism With Markedly High Prolactin

Frontiers in Endocrinology, 2016
Secondary Pituitary enlargement due to primary hypothyroidism is not a common manifestation. The loss of thyroxin feedback inhibition in primary hypothyroidism causes overproduction of thyroid-releasing hormone (TRH), which results in secondary pituitary
MOHD SALEEM ANSARI, MUSSA H. ALMALKI, MUSSA H. ALMALKI   +2 more
doaj   +1 more source

Lack of GPNMB Is Associated With Altered Lipid and Glucose Metabolism and Disrupted Diurnal Hepatic Glycogen Regulation

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Loss of GPNMB function in mice fed a high‐fat/high‐fructose diet aggravated adiposity and dyslipidemia while preserving systemic glucose tolerance. This phenotype was associated with impaired hepatic AKT–FOXO1 signaling, increased NF‐κB activation, altered glycogen metabolism, and rhythmic disturbances in energy expenditure and clock gene expression ...
Eliz Maria de Oliveira Furtado, Lina Jegodzinski, Juliano Jefferson da Silva, Ana Flávia Tostes, Lucas dos Santos, Pietra Souza Barsanele, Beatriz Santana‐Lima, Luciana Chagas Caperuto, Mery Natali Silva Abreu, Darko Castven, Andrea Schenk, Danusa Soares Dias, Jens U. Marquardt, Maristela Oliveira Poletini, Leonardo Vinícius Monteiro de Assis, Maria Nathália Moraes   +15 more
wiley   +1 more source

Hypothyroidism as Prognostic Factor in Cutaneous Melanoma: A 1553‐Patient Single‐Center Study

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Cutaneous melanoma is a rising global health concern and identifying modifiable or associated risk factors remains essential for improving prognostic stratification. Hypothyroidism, affecting approximately 5.1% of the general population in Germany, has been associated with various malignancies. This study investigates the prevalence
Julie Klose, Filipa Almeida Oliveira, Charalampos Varnava, Philipp Wiebringhaus, Grit Sophie Herter‐Sprie, Hans‐Joachim Schulze, Tobias Hirsch, Sascha Wellenbrock, Maximilian Kueckelhaus   +8 more
wiley   +1 more source

Role of thyrotropin-releasing hormone test in re-evaluation of congenital hypothyroidism

Kaohsiung Journal of Medical Sciences, 2014
The thyrotropin-releasing hormone (TRH) test is useful for differentiating central and primary hypothyroidism, and is also valuable for diagnosing hypothyroidism. The threshold of the TRH test is usually set at 10–40 mIU/L.
Li-Min Chen, Yen-Chun Chen, Hui-Pin Hsiao, Bai-Hsiun Chen, Mei-Chyn Chao   +4 more
doaj   +1 more source

Sequential Amiodarone‐Induced Thyroid Dysfunction: From Myxedema Coma to Late‐Onset Type 1 Thyrotoxicosis After Drug Withdrawal

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Amiodarone therapy may induce thyroid dysfunction in approximately 20% of patients, either amiodarone‐induced hypothyroidism (AIH) or thyrotoxicosis (AIT). Both situations may occur at any time during treatment or even months to years after drug withdrawal due to tissue storage with slow systemic release.
Daniela M. Soares, Lia Ferreira
wiley   +1 more source

Thyrotropin-releasing hormone in cardiovascular pathophysiology

Regulatory Peptides, 2005
Thyrotropin (TSH)-releasing hormone (TRH) also known as thyroliberin was the first of a number of peptides exerting several roles as a hormone and as a neuropeptide. Its ubiquitous distribution in the hypothalamus and in the extrahypothalamic regions and its diverse pharmacological and physiological effects are all features of its dual functions.
Garcia, Silvia Ines, Pirola, Carlos José   +1 more
openaire   +3 more sources

Thyroglobulin Autoantibodies Do Not Influence the Outcome of Patients With Differentiated Thyroid Carcinoma

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
Thyroglobulin autoantibodies (TgAb) occur in roughly 25% of thyroid cancer patients and interfere with Tg measurement. Our study shows TgAb presence does not affect patient outcomes, but close monitoring is essential to avoid overtreatment. ABSTRACT Introduction Thyroglobulin (Tg) is a sensitive and specific marker for differentiated thyroid carcinoma (
C. Bornemann, C. Bouter
wiley   +1 more source

The challenge of pituitary hyperplasia differential diagnosis in a young girl with growth arrest

Atti della Accademia Peloritana dei Pericolanti - Classe di Scienze Medico-Biologiche
Growth arrest is an alarming condition which requires precise and tempestive investigations in order to provide accurate diagnosis. Long-standing primary hypothyroidism (PHT) may rarely occur as a growth arrest as the only clinical sign at onset in ...
Aurora Lanzafame, Tiziana Abbate, Giuseppina Zirilli, Flavia Caime, Domenico Corica, Malgorzata Wasniewska   +5 more
doaj   +1 more source

Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning

Frontiers in Cellular Neuroscience, 2018
Thyrotropin-releasing hormone (TRH) regulates various physiological activities through activation of receptors expressed in a broad range of cells in the central nervous system.
Masashi Watanave, Yasunori Matsuzaki, Yasuyo Nakajima, Atsushi Ozawa, Masanobu Yamada, Hirokazu Hirai, Hirokazu Hirai   +6 more
doaj   +1 more source