Results 31 to 40 of about 26,589 (251)

Iodine deficiency is associated with increased thyroid hormone sensitivity in individuals with elevated TSH

European Thyroid Journal, 2023
Objective: Central sensitivity of thyroid hormone refers to the sensitivity of hypothalamic– pituitary–thyroid (HPT) axis to the change in circulating free thyroxine (fT4).
Ying Sun, Di Teng, Lei Zhao, Xiaoguang Shi, Yongze Li, Zhongyan Shan, Weiping Teng   +6 more
doaj   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

Effect of Delayed Elevation of Thyrotropin on Feeding Intolerance in Very Low Birth Weight Infants [PDF]

Neonatal Medicine, 2019
Purpose We investigated the effect of delayed elevation of thyrotropin (TSH) (deTSH) on gastrointestinal motility in very low birth weight infants (VLBWI).
Ju Kyung Hyun, So Yoon Choi, Yu Jin Jung, Jung Hyun Lee   +3 more
doaj   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Associations of gestational thyrotropin levels with disease progression among pregnant women with differentiated thyroid cancer: a retrospective cohort study

Frontiers in Endocrinology
PurposePregnant women with a diagnosis of differentiated thyroid cancer (DTC) were potentially high-risk but largely ignored study population. We aimed to explore whether gestational thyrotropin levels were associated with progression of DTC.MethodsWe ...
Xin Li, Peng Fu, Wu-Cai Xiao, Fang Mei, Fan Zhang, Shanghang Zhang, Jing Chen, Rui Shan, Bang-Kai Sun, Shi-Bing Song, Chun-Hui Yuan, Zheng Liu   +11 more
doaj   +1 more source

Recent Advances in Functional Liver Volumetry: Emphasis on 99mTc‐GSA SPECT/CT Fusion Imaging

Annals of Gastroenterological Surgery, EarlyView.
Functional liver volumetry enables more accurate assessment of the future liver remnant by integrating anatomical and functional information, improving risk stratification before major hepatectomy. Among available techniques, 99mTc‐GSA SPECT/CT fusion imaging enables precise regional functional assessment and more reliable prediction of post ...
Toru Beppu, Toshiro Masuda, Yasunori Nagayama, Hidetoshi Nitta, Hiromitsu Hayashi   +4 more
wiley   +1 more source

Ambient biothermal stress, preconceptional thyrotropin abnormalities, and the risk of preterm birth: a nationwide Chinese cohort study

Nature Communications
Epidemiologic evidence on thermal stress and preterm birth (PTB) is based on ambient temperature rather than a biothermal metric. Thyrotropin abnormalities have been associated with PTB and may increase thermal vulnerability.
Xinghou He, Mengyao Li, Hongbing Xu, Bin Zhang, Xinyi Lv, Long Wang, Chuanyu Zhao, Xuyang Shan, Yuan He, Yan Fang, Yuanyuan Wang, Huiying Xu, Jihong Xu, Xiaoming Song, Ya Zhang, Hongguang Zhang, Ying Yang, Xu Ma, Wei Huang   +18 more
doaj   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Evaluation of Thyroid Function Tests of Primary Hypothyroidism Diagnosed Cases’ by Using Big Data: 13-Year Single Center Experience

Journal of Biostatistics and Epidemiology, 2021
Objective: Our aim is to perform an analysis, using big data, of cases diagnosed with primary hypothyroidism and aged 18 and over who presented to our hospital, by evaluating the laboratory and socio-demographic data of the patients.
Ibrahim Sahin, Canan Ersoy, Ilker Ercan, Melahat Dirican   +3 more
doaj   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source