Results 51 to 60 of about 37,310 (276)

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

Advanced Science, EarlyView.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu, Le Xie, Yuan Jin, Sen Chen, Xinyu Shi, Yanjun Zong, Zhengdong Zhao, Wei‐Jia Kong, Yu Sun   +8 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Clinical and laboratory characteristics of patients with thyroid diseases with and without alanine aminotransferase levels above the upper tertile – Cross-sectional analytical study

Archives of Endocrinology and Metabolism, 2015
Objective Thyroid disease affects 6.6% of the general population. The liver is fundamental in metabolizing thyroid hormones, and hepatocytes are often affected in thyroid disease.
Nathanael de Oliveira e Silva, Marcelo Fernando Ronsoni, Bruno da Silveira Colombo, Carina Gabriela Corrêa, Simone Aiko Hatanaka, Maria Heloisa Büsi da Silva Canalli, Leonardo de Lucca Schiavon, Janaína Luz Narciso-Schiavon   +7 more
doaj   +1 more source

Record‐High Latent Heat, Ultra‐Fast Relaxation and Closed‐Loop Recycling Double‐Brush Polymer Networks for Self‐Adaptive Thermal Interface Management

Advanced Science, EarlyView.
By grafting dense long double‐brush chains, we synthesized bottlebrush networks with high theoretical enthalpy. Their low entanglement, combined with dynamic bonds, promotes crystalline domain reorganization and minimizes enthalpy loss, achieving a record enthalpy of 240.7 J·g−1.
Qiguang Liu, Yanyun Li, Zhenghao Wu, Junjie Cheng, Chang Jing, Jue Cheng, Jiahao Ma, Junying Zhang   +7 more
wiley   +1 more source

Are physiological oscillations physiological?

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

Sexually dimorphic dynamics of thyroid axis activity during fasting in rats

Frontiers in Bioscience-Landmark, 2020
Starvation induces tertiary hypothyroidism in adult rodents. Response of the hypothalamus-pituitary-thyroid (HPT) axis to starvation is stronger in adult males than in females.
Patricia Joseph-Bravo, Iván Lazcano, Lorraine Jaimes-Hoy, Mariana Gutierrez-Mariscal, Edith Sanchez-Jaramillo, Rosa María Uribe, Jean-Louis Charli   +6 more
doaj   +1 more source

Association between Thyroid Function and Respiratory Distress Syndrome in Preterm Infants

Pediatric Reports, 2022
Thyroid hormones are known to influence the production and secretion of pulmonary surfactant. The objective of this study was to explore the relationship between respiratory distress syndrome (RDS) and thyroid hormones.
Yonghyuk Kim, Youngjin Kim, Meayoung Chang, Byoungkook Lee   +3 more
doaj   +1 more source

Confined B‐Cell Reconstruction and High T‐Cell Clonality Define Clinical Response to Cladribine Treatment

Annals of Neurology, EarlyView.
Cladribine tablets are approved for relapsing multiple sclerosis, mediating their clinical effect by moderately depleting lymphocytes. In a prospective, monocentric study including 22 patients completing 2 annual cycles of cladribine, B‐ and T‐cell receptor repertoires and relapse activity were assessed at baseline and after 24 months. T‐cell clonality
Tilman Schneider‐Hohendorf, Maria Eveslage, Timo Wirth, Christian Wünsch, Eva M. Schumann, Jan D. Lünemann, Heinz Wiendl, Luisa Klotz, Nicholas Schwab   +8 more
wiley   +1 more source

TSHOMA: A RARE PITUITARY TUMOR

Khyber Medical University Journal, 2021
INTRODUCTION: TSH-secreting pituitary adenomas (TSHoma) or thyrotropinoma are rare pituitary tumors that secrete an abnormal Thyroid Stimulating Hormone (TSH) which constitutes up to 1%–2% of all pituitary adenomas. Patients often remain misdiagnosed for
Muhammad Salman Aamir, Tahir Ghaffar, Muhammad Qasim, Mian Sameer Ahmed, Afrasiyab Khalil, Ali Sibtain   +5 more
doaj   +1 more source

Risk of cardiac, neuropsychiatric and musculoskeletal adverse events with levothyroxine: Systematic review

British Journal of Clinical Pharmacology, EarlyView.
Abstract Levothyroxine (LT4) is the standard treatment for hypothyroidism and the most widely prescribed medication worldwide. Although generally safe, regulatory reports list potential cardiac, neuropsychiatric and musculoskeletal adverse events (AEs). Clarifying their clinical relevance is essential.
Bala Swetha Baskaran, Mohammad Ali Omrani, Flory T. Muanda   +2 more
wiley   +1 more source