Results 51 to 60 of about 66,698 (357)
TSHOMA: A RARE PITUITARY TUMOR
Khyber Medical University Journal, 2021 INTRODUCTION: TSH-secreting pituitary adenomas (TSHoma) or thyrotropinoma are rare pituitary tumors that secrete an abnormal Thyroid Stimulating Hormone (TSH) which constitutes up to 1%–2% of all pituitary adenomas. Patients often remain misdiagnosed for
Muhammad Salman Aamir +5 more
doaj +1 more source
Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report [PDF]
, 2017 There is a frequently encountered subset of hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine.
Benvenga, S +2 more
core +1 more source
Anti-Thyrotropin Antibody Interference in Thyrotropin Assays [PDF]
Clinical Chemistry, 1998 We read with interest the paper by Despres and Grant (1) on antibody interference in thyroid assays. Thyroid hormone autoantibodies, heterophile antibodies, and rheumatoid factors are certainly the main sources of artifacts. As mentioned by the authors, anti-thyrotropin (anti-TSH) antibodies are more uncommon but may nevertheless deserve additional ...
Jean Louis Wemeau +3 more
openaire +1 more source
Advanced Materials, EarlyView.A multifunctional MXene‐based membrane integrates photothermal evaporation and photocatalytic vapor splitting in a sweeping‐gas membrane distillation (PTC‐SGMD) platform, simultaneously generating freshwater and hydrogen. The SrTiO3/MX@PVDF interface leverages broad‐spectrum solar absorption, efficient heat/mass transfer, and gas–solid catalysis to ...
Jiawei Sun +11 more
wiley +1 more source
TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
Advanced Science, EarlyView.This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang +16 more
wiley +1 more source
Archives of Endocrinology and Metabolism, 2015 Objective Thyroid disease affects 6.6% of the general population. The liver is fundamental in metabolizing thyroid hormones, and hepatocytes are often affected in thyroid disease.
Nathanael de Oliveira e Silva +7 more
doaj +1 more source
Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation
Advanced Science, EarlyView.Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li +18 more
wiley +1 more source
Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development
Advanced Science, EarlyView.Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu +8 more
wiley +1 more source
Thyroid hormone therapy for older adults with subclinical hypothyroidism [PDF]
, 2017 The Authors ...
Bauer, Douglas C. +2 more
core +2 more sources
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source