Results 101 to 110 of about 82,650 (256)

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Modeling of the Stress-Strain State of the Tibia-Fixator

Механика машин, механизмов и материалов, 2012
Article focuses on the method of three-dimensional geometric modeling of the tibia based on data of computed tomography, also techniques of determining the optimal geometrical and structural parameters of the proximal tibia fixator by taking into account
A.A. Sitnik , A.S. Kovenya , T.A. Kovenya , D.A. Chernyshev   +3 more
doaj  

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

AN ENHANCED TIBIA FRACTURE DETECTION TOOL USING IMAGE PROCESSING AND CLASSIFICATION FUSION TECHNIQUES IN X-RAY IMAGES [PDF]

, 2011
Automatic detection of fractures from x-ray images is considered as an important process in medical image analysis by both orthopaedic and radiologic point of view.
Dr. S.K.Mahendran, I.Kadar Shereef
core  

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Prevalencia de fracturas abiertas de la diáfisis tibial por accidente en moto

, 2010
De enero a diciembre de 2009 se trataron 90 pacientes con fracturas diafisarias de tibia, en el HCAM, de la ciudad de Quito; de las cuales 76 fueron expuestas y 14 fueron cerradas. De las fracturas causadas por accidente de moto el 94% fueron expuestas y
Narváez León, Carolina Ivette
core   +1 more source

Traumatic physeal separations of the distal tibia. Occurrence, forms, treatment strategies [PDF]

, 2011
Traumatische Epiphysenfugenlösungen [Einteilung von Salter u. Harris (SH) I/II] der unteren Extremität sind selten. Mit Komplikationen behaftete Verläufe werden in 2,2–39,6% der Fälle berichtet.
Kraus, Ralf, Herbst, Ulrike, U. Herbst, R. Kraus, R. Schnettler, G. Perler, C. Röder, Röder, Christoph, Perler, Gosia, Schnettler, Reinhard   +9 more
core   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

OSSEOUS CYSTS OF THE TIBIA [PDF]

The American Journal of the Medical Sciences, 1901
n ...
openaire   +1 more source