Results 81 to 90 of about 312,235 (310)

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Surgical nonunion treatment of large-sized defects of femur and tibia based on the diamond concept

Bone & Joint Open
Aims: The aim of this study was to evaluate the radiological outcome of patients with large bone defects in the femur and tibia who were treated according to the guidelines of the diamond concept in our department (Centre for Orthopedics, Trauma Surgery,
Sebastian Findeisen, Louis Mennerat, Thomas Ferbert, Lars Helbig, Tim N. Bewersdorf, Tobias Großner, Christian Schamberger, Gerhard Schmidmaier, Michael Tanner   +8 more
doaj   +1 more source

Changes in the Outer Shape, Inner Structure and Bone Mineral Density of the Tibia in Growing Japanese Quail, Coturnix japonica

The Journal of Poultry Science, 2007
The length, width and thickness of cortical bone at the central diaphysis, as well as the inner structure and bone density in the tibia of growing Japanese quail (Coturnix japonica) were examined from hatching to 100 days of age at 10-day intervals to ...
Kouichi Nishimura, Susumu Miyamoto, Takao Takeda, Eishi Ayukawa, Toshie Sugiyama, Seiji Kusuhara   +5 more
doaj   +1 more source

Effects of eggshell temperature pattern during incubation on tibia characteristics of broiler chickens at slaughter age

Poultry Science, 2020
This study was designed to determine effects of eggshell temperature (EST) pattern in week 2 and week 3 of incubation on tibia development of broiler chickens at slaughter age.
B.C. Güz, R. Molenaar, I.C. de Jong, B. Kemp, M. van Krimpen, H. van den Brand   +5 more
doaj   +1 more source

The complex tibial organ of the New Zealand ground weta: sensory adaptations for vibrational signal detection [PDF]

, 2017
In orthopteran insects, a complex tibial organ has evolved to detect substrate vibrations and/or airborne sound. Species of New Zealand weta (Anostostomatidae) with tympanal ears on the foreleg tibia use this organ to communicate by sound, while in ...
Field, Laurence H., Lomas, Kathryn, Strauß, Johannes   +2 more
core   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Finite element analysis confirms the optimal apex position in medial opening wedge high tibial osteotomy to avoid lateral hinge fracture

Journal of Experimental Orthopaedics
Purpose Lateral hinge fracture is a significant complication of medial opening wedge high tibial osteotomy. While fracture risk is closely associated with the osteotomy apex position, the optimum position remains variable within the literature.
Humza T. Osmani, Radhika Gupta, Rosemary Earl, Stanisław Tomaszczyk, Tom Turmezei, Neil A. Segal, Michael Sutcliffe, Joel Melton   +7 more
doaj   +1 more source

Validation of Kinematics and Lower Extremity Injuries Estimated by Total Human Model for Safety in SUV to Pedestrian Impact Test

Journal of Biomechanical Science and Engineering, 2010
In recent years, the distributions of vehicle types include a substantial number of Sport Utility Vehicles (SUVs). Pedestrian injury distribution of SUVs is different from that of passenger cars and head, torso, and lower extremities are most frequently ...
Tsuoyoshi YASUKI, Yasuo YAMAMAE
doaj   +1 more source

Descriptions of new genera and species of South African spiders [PDF]

, 2011
The present paper contains descriptions of 4 new genera and 62 new species of South African Spiders contained in the Collection of the South African Museum.
Purcell, William Frederick
core  

DESCRIPTION OF \u3ci\u3eHAKKA\u3c/i\u3e, A NEW GENUS OF JUMPING SPIDER (ARANEAE, SALTICIDAE) FROM HAWAII AND EAST ASIA [PDF]

, 2001
We describe a new genus for a jumping spider that was originally placed in the large genus Menemerus Simon 1868, from which the new genus is clearly different. They were later reclassified as Icius, then as Pseudicius, and still later as Salticus.
Berry, James W., Prószyński, Jerzy
core   +2 more sources