Results 91 to 100 of about 312,235 (310)

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

\u3ci\u3eSminthurus Mencenbergae,\u3c/i\u3e New Species from Canada and Michigan (Collembola: Sminthuridae) [PDF]

, 2017
A new species, Sminthurus (Sminthurus) mencenbergar Snider, is described from Canada and ...
Snider, Richard J
core   +2 more sources

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Protein Source and Nutrient Density in the Diets of Male Broilers from 8 to 21 Days of Age: Effects on Tibia Dimension, Breaking Strength, and Mineral Density

The Journal of Poultry Science, 2015
The effects of supplemental protein source, and amino acid (AA) and apparent metabolizable energy (AME) densities in the diets of broilers on their growth performance and intestinal development were reported in companion studies.
Xi Wang, E. David Peebles, R. Mark Bricka, Wei Zhai   +3 more
doaj   +1 more source

Apionidae from North and Central America : 6. Description of new species of Apionion Kissinger, Coelocephalapion Wagner and Trichapion Wagner (Coleoptera) [PDF]

, 1999
Two new species of Trichapion Wagner, T. baranowskii and T. santaritae, are described from Madera Canyon, near Tucson, Arizona. Six new species of Coelocephalapion Wagner are described: C. dilox (Mexico), C.
Kissinger, David G.
core  

Predicting cortical bone adaptation to axial loading in the mouse tibia [PDF]

, 2015
The development of predictive mathematical models can contribute to a deeper understanding of the specific stages of bone mechanobiology and the process by which bone adapts to mechanical forces.
A. A. Pitsillides, A. F. Pereira, B. Javaheri, Cavanagh PR, Cowin SC, Frost HM, Phillips ATM, Robling AG, S. J. Shefelbine, Steck R   +9 more
core   +3 more sources

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Three New Species and a Key for the Genus Callidora (Hymenoptera: Ichneumonidae) [PDF]

, 2017
Excerpt: The genus Callidora (subfamily Porizontinae) has traditionally contained a single European species, Callidora albovincta (Holmgren). Townes (1969) redefined the genus and included a second species (Campoplex analis Gravenhorst). At the same time
Tigner, Timothy C.
core   +3 more sources

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source