Results 1 to 10 of about 14,967 (152)

The effect of antiplatelet drug on coronary endothelial and microvascular function: comparison with ticagrelor and clopidogrel [PDF]

The Korean Journal of Internal Medicine, 2021
Background/Aims Coronary endothelial and microvascular function play important roles in cardiovascular disease. We aimed to evaluate the effect of ticagrelor on coronary artery function and tested the antiplatelet effect of low dose ticagrelor in East ...
Woong Gil Choi, Gi Chang Kim, Cheol Ho Lee, Hye Young Kim, Dong Woon Kim   +4 more
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Contributions of UDP-Glucuronosyltransferases to Human Hepatic and Intestinal Metabolism of Ticagrelor and Inhibition of UGTs and Cytochrome P450 Enzymes by Ticagrelor and its Glucuronidated Metabolite

Frontiers in Pharmacology, 2021
Ticagrelor is the first reversibly binding, direct-acting, oral P2Y12 receptor inhibitor. The contribution of UDP-glucuronosyltransferases (UGTs) enzymes to the metabolism of ticagrelor to its glucuronide conjugation, ticagrelor-O-glucuronide, in human ...
Shuaibing Liu, Lei Hou, Cai Li, Yibo Zhao, Xia Yao, Xiaojian Zhang, Xin Tian   +6 more
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Age‐Dependent Effect of Ticagrelor Monotherapy Versus Ticagrelor With Aspirin on Major Bleeding and Cardiovascular Events: A Post Hoc Analysis of the TICO Randomized Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background We aimed to evaluate the age‐dependent effect of ticagrelor monotherapy after 3‐month dual‐antiplatelet therapy (DAPT) versus ticagrelor‐based 12‐month DAPT on major bleeding and cardiovascular events in patients with acute coronary syndrome ...
Byung Gyu Kim, Sung‐Jin Hong, Byeong‐Keuk Kim, Seung‐Jun Lee, Chul‐Min Ahn, Dong‐Ho Shin, Jung‐Sun Kim, Young‐Guk Ko, Donghoon Choi, Myeong‐Ki Hong, Yangsoo Jang   +10 more
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Implementation of Ticagrelor Reduced Mortality in Routine Clinical Care: Evidence From a Natural Experiment Including 109 995 Patients With Myocardial Infarction in Sweden

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Effectiveness estimates from observational studies on ticagrelor use in routine clinical care are conflicting, with some contrary to the results of the pivotal randomized controlled trial of ticagrelor in acute coronary syndrome.
Kasper Johannesen, Jonathan Siverskog, Martin Henriksson, Magnus Janzon, Bertil Lindahl, Erik Grönqvist   +5 more
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Hospital‐Level Variation in Ticagrelor Use in Patients With Acute Coronary Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Despite improved outcomes associated with ticagrelor compared with clopidogrel in acute coronary syndrome (ACS), many studies have demonstrated slow adoption of ticagrelor in the United States because of its increased cost. Less is known about
Aya F. Ozaki, Cynthia A. Jackevicius, Alice Chong, Maneesh Sud, Jiming Fang, Peter C. Austin, Dennis T. Ko   +6 more
doaj   +1 more source

Low-dose and standard-dose ticagrelor compared with clopidogrel in patients with acute coronary syndromes: A cohort study from china

Frontiers in Cardiovascular Medicine, 2022
PurposePrevious trials have demonstrated that ticagrelor was superior to clopidogrel in acute coronary syndrome (ACS) patients. However, several recent studies showed that ticagrelor was associated with a significantly higher risk of bleeding compared ...
Wenxing Peng, Yunnan Zhang, Yunnan Zhang, Yang Lin   +3 more
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The effect of ticagrelor on ischemia-reperfusion injury of kidney: is the pleiotropic effect a valid factor? [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2017
Bu çalışmada, ticagrelor"un ratların böbreğinde oluşturulan iskemi-reperfüzyon hasarına karşı koruyucu etkisinin histolojik, biyokimyasal ve immünohistokimyasal yöntemler kullanılarak tanımlanması amaçlanmıştır.
Murat BAĞCIOĞLU, Ramazan KOCAASLAN, Mehmet USLU, Gülname FINDIK GÜVENDİ   +3 more
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Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice

JACC: Basic to Translational Science, 2023
Summary: In addition to its potent antiplatelet activity, ticagrelor possesses antibacterial properties against gram-positive bacteria. We wondered whether the typical clinical dosage of ticagrelor could prevent the development of infective endocarditis ...
Cécile Oury, PhD, Severien Meyers, MSc, Nicolas Jacques, BS, Kirsten Leeten, MSc, Zheshen Jiang, MSc, Lucia Musumeci, PhD, Marleen Lox, BS, Margaux Debuisson, BS, Eric Goffin, PharmD, Bernard Pirotte, PharmD, PhD, Philippe Delvenne, MD, PhD, Alain Nchimi, MD, PhD, Cédric Hubert, PharmD, PhD, Mélanie Heptia, BS, Philippe Hubert, PharmD, PhD, Marijke J.E. Kuijpers, PhD, Thomas Vanassche, MD, PhD, Kimberly Martinod, PhD, Peter Verhamme, MD, PhD, Patrizio Lancellotti, MD, PhD   +19 more
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Comparison of bioavailability and antiplatelet action of ticagrelor in patients with ST-elevation myocardial infarction and non-ST-elevation myocardial infarction: A prospective, observational, single-centre study. [PDF]

PLoS ONE, 2017
Data from available studies suggest that the presence of ST-elevation myocardial infarction (STEMI) may be associated with delayed and attenuated ticagrelor bioavailability and effect compared with non-ST-elevation myocardial infarction (NSTEMI).In a ...
Piotr Adamski, Joanna Sikora, Ewa Laskowska, Katarzyna Buszko, Małgorzata Ostrowska, Julia M Umińska, Adam Sikora, Natalia Skibińska, Przemysław Sobczak, Urszula Adamska, Danuta Rość, Aldona Kubica, Przemysław Paciorek, Michał P Marszałł, Eliano P Navarese, Diana A Gorog, Jacek Kubica   +16 more
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Ticagrelor Removal From Human Blood

JACC: Basic to Translational Science, 2017
Summary: The authors devised an efficient method for ticagrelor removal from blood using sorbent hemadsorption. Ticagrelor removal was measured in 2 sets of in vitro experiments.
George O. Angheloiu, MD, Gabriel B. Gugiu, PhD, Cristian Ruse, PhD, Rishikesh Pandey, PhD, Ramachandra R. Dasari, PhD, Carl Whatling, PhD   +5 more
doaj   +1 more source