Results 61 to 70 of about 18,009 (296)

Warfarin interactions: a letter to editor [PDF]

Patient Safety and Quality Improvement Journal, 2019
Today, with the advances in the treatment of cardiovascular patients such as intravascular stents, cardiac valves and intraventricular pacing and heart transplantation, many patients require the use of anticoagulants such as warfarin, sprain, Plavix ...
Sayyed Majid Sadrzadeh, Elnaz Vafadar Moradi, Seyed Mohammad Mousavi, Behrang Rezvani Kakhki, Shaghayegh Rahmani   +4 more
doaj   +1 more source

Antiaggregant therapy in neurological practice: objectives and possibilities

Неврология, нейропсихиатрия, психосоматика, 2010
Based on the data available in the literature, the authors consider the prevention of ischemic stroke and other cardiovascular diseases in high-risk group patients.
E. V. Portnyagina, A. F. Portnyagin
doaj   +1 more source

Ticagrelor: A Reversible P2Y12 Inhibitor in Preventionof Thrombotic Events

RUHS Journal of Health Sciences, 2023
Antiplatelet drugs play a crucial role in patients of coronary artery diseases, cerebrovascular diseases, and maintaining the patency of revascularised arteries and stents after coronary angioplasty.
Uma Advani , Charu Jain , Alka Bansal , Neha Sharma , Kopal Sharma
doaj   +1 more source

Exposure–Response Modeling and Simulation to Identify Optimal Mavacamten Posology When Coadministered with CYP3A4 and CYP2C19 Inhibitors in Patients with Obstructive HCM

The Journal of Clinical Pharmacology, EarlyView.
Abstract Mavacamten, a cardiac myosin inhibitor, is primarily metabolized by the cytochrome P450 (CYP) enzymes CYP2C19 and CYP3A4, and coadministration with strong CYP3A4 or CYP2C19 inhibitors was contraindicated in patients with obstructive hypertrophic cardiomyopathy (HCM) in the US Prescribing Information. This study assessed the safety and efficacy
Samira Merali, Haden Bunn, Caroline Sychterz, Manting Chiang, Shilpa Puli, Amy J. Sehnert, Bindu Murthy, Joga Gobburu   +7 more
wiley   +1 more source

The "Safari" technique to perform difficult subintimal infragenicular vessels [PDF]

, 2007
The purpose of this study was to describe the efficacy of planned combined subintimal arterial flossing with antegrade– retrograde intervention (SAFARI) to obtain the precise recanalization of the patent portion of a distal runoff vessel in critical ...
Colangelo,V, Gandini,R, Maresca,L, Pampana,E, Pipitone,V, Reale,Ca, Simonetti,G, Spinelli,A, Stefanini,M   +8 more
core   +1 more source

Diagnosis and Management of Hypersensitivity to Antiplatelet Drugs: EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Antiplatelet drug (APD) therapy is the cornerstone for the prevention of atherosclerotic cardiovascular disease. The main APDs are aspirin and thienopyridines, particularly clopidogrel. These drugs may induce hypersensitivity reactions (HSRs).
Gabriele Cortellini, Alla Nakonechna, Annick Barbaud, Sevim Bavbek, Gianfranco Calogiuri, Inmaculada Doña, Violeta Kvedariene, Jose Julio Laguna Martinez, Serena Liberati, Mauro Pagani, Antonino Romano   +10 more
wiley   +1 more source

Factors affecting adherence to guidelines for antithrombotic therapy in elderly patients with atrial fibrillation admitted to internal medicine wards [PDF]

, 2010
Current guidelines for ischemic stroke prevention in atrial fibrillation or flutter (AFF) recommend Vitamin K antagonists (VKAs) for patients at high-intermediate risk and aspirin for those at intermediate-low risk.
Altomare, E, Anastasio, L, Barreca, A, Bertolini, D, Bertolino, G, Bertucci, L, Bonelli, A, Cagnoni, C, Casella, G, Castoldi, L, Cavallo, P, Cazzaniga, M, Centenaro, GR, Colombo, S, Coralli, A, CORRAO, Salvatore, Cortellaro, M, Cuccuru, LM, Cuccurullo, O, Deidda, S, Dentamaro, G, Di Sciacca, R, Durante Mangoni, E, Fabio, G, Famularo, G, Fava, R, Ferrari, B, Fiorentini, A, Gaudenzi, P, Giannico, I, Giordano, A, Giusto, L, Gobbo, G, Gualandi, S, Hila, D, Incasa, E, Iorio, A, Liberato, NL, Longhini, C, Macura, A, Magagnotti, G, Mammarella, A, Mannucci, PM, Manucra, A, Marcucci, M, Marengoni, A, Mari, D, Matino, D, Meroni, MR, Micale, G, Molino, C, Monzani, V, Morabito, C, Moreo, G, Musca, G, Nobili, A, Pasina, L, Pasqui, AL, Perciccante, A, Picardi, A, Pinto, D, Puccetti, L, Quagliolo, M, Quercioli, A, Raparelli, V, Rasciti, L, Rizzoli, E, Rizzoni, D, Romanelli, G, Rondinella, S, Rossi, DP, Rossio, R, Rozzini, R, Sajeva, MR, Salerno, F, Savojardo, V, Semplicini, A, Serviddio, G, Tedeschi, A, Tettamanti, M, Tofi, C, TUTTOLOMONDO, Antonino, Vanoli, M, Vergani, C.   +83 more
core   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO3-Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus

Microbiology Spectrum, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) strains pose major treatment challenges due to their innate resistance to most β-lactams under standard in vitro antimicrobial susceptibility testing conditions.
Selvi C. Ersoy, Barbara Gonçalves, Gonçalo Cavaco, Adhar C. Manna, Rita G. Sobral, Cynthia C. Nast, Richard A. Proctor, Henry F. Chambers, Ambrose Cheung, Arnold S. Bayer   +9 more
doaj   +1 more source

Assessing Cytochrome P450 Drug Interaction Risk for Dordaviprone Using Physiologically Based Pharmacokinetic Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 10, Page 1695-1704, October 2025.
ABSTRACT A physiologically based pharmacokinetic (PBPK) model was developed and verified for dordaviprone, a small molecule with antitumor effects in glioma patients. The model was applied to assess the drug–drug interaction (DDI) potential of dordaviprone as a victim of CYP3A4 inhibitors and inducers, and as a perpetrator of CYP3A4, CYP2C8, CYP2D6 ...
Swati Jaiswal, Nikunjkumar K. Patel, Hannah M. Jones, Savannah McFeely, Shamia L. Faison, Tim Tippin, Odin Naderer   +6 more
wiley   +1 more source