Results 61 to 70 of about 17,756 (301)

BUSM News and Notes [PDF]

open access: yes, 1982
Monthly newsletter providing updates of interest to the Boston University School of Medicine ...
Boston University School of Medicine Office of Informational Services
core  

Assessing Cytochrome P450 Drug Interaction Risk for Dordaviprone Using Physiologically Based Pharmacokinetic Modeling

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT A physiologically based pharmacokinetic (PBPK) model was developed and verified for dordaviprone, a small molecule with antitumor effects in glioma patients. The model was applied to assess the drug–drug interaction (DDI) potential of dordaviprone as a victim of CYP3A4 inhibitors and inducers, and as a perpetrator of CYP3A4, CYP2C8, CYP2D6 ...
Swati Jaiswal   +6 more
wiley   +1 more source

ANTITHROMBOTIC THERAPY OF ISCHEMIC HEART DISEASE: FROM FAST ACTING ANTIAGGREGANTS TO STATINES AND NITRATE OXIDE. IS IT REAL?

open access: yesРациональная фармакотерапия в кардиологии, 2016
Mechanisms of atherothrombosis in atherosclerosis of coronary arteries are described. Mechanism of action and clinical efficiency of antithrombotic and antiplatelet medicines such as acetylsalicylic acid, warfarin, ticlopidine and clopidogrel are ...
I. A. Latfullin, A. A. Podolskaya
doaj   +1 more source

Diagnosis and Management of Hypersensitivity to Antiplatelet Drugs: EAACI Position Paper

open access: yesAllergy, EarlyView.
ABSTRACT Antiplatelet drug (APD) therapy is the cornerstone for the prevention of atherosclerotic cardiovascular disease. The main APDs are aspirin and thienopyridines, particularly clopidogrel. These drugs may induce hypersensitivity reactions (HSRs).
Gabriele Cortellini   +10 more
wiley   +1 more source

Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO3-Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus

open access: yesMicrobiology Spectrum, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) strains pose major treatment challenges due to their innate resistance to most β-lactams under standard in vitro antimicrobial susceptibility testing conditions.
Selvi C. Ersoy   +9 more
doaj   +1 more source

Comparative Risk of Major Bleeding With Concomitant Use of Oral Anticoagulants and Corticosteroid Bursts

open access: yesClinical and Translational Science, Volume 18, Issue 8, August 2025.
ABSTRACT The choice of oral anticoagulants and oral corticosteroid (OCS) burst cotherapy may influence the risk of major bleeding; however, this risk remains poorly characterized. We aimed to quantify the comparative safety of non–vitamin K oral anticoagulants (NOACs) versus warfarin on major bleeding while receiving OCS burst cotherapy among patients ...
Tsung‐Chieh Yao   +4 more
wiley   +1 more source

Anticoagulant versus antiplatelet therapy for acute ischemic stroke [PDF]

open access: yes, 2008
Acute ischaemic stroke is a leading cause of death in Canada and should be a priority in health care. This paper defines acute ischaemic stroke and provides current statistics, economic costs, risk factors, treatments, and management options.

core   +1 more source

Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (fantastic) study.

open access: yesCirculation, 1998
BACKGROUND Dual therapy with ticlopidine and aspirin has been shown to be as effective as or more effective than conventional anticoagulation in patients with an optimal result after implantation of intracoronary metallic stents.
M. Bertrand   +15 more
semanticscholar   +1 more source

Vonoprazan or Proton Pump Inhibitor for Gastric Endoscopic Submucosal Dissection in Patients Taking Antithrombotic Agents

open access: yesJournal of Gastroenterology and Hepatology, Volume 40, Issue 8, Page 1890-1898, August 2025.
ABSTRACT Background and Aim Delayed bleeding is a major concern after gastric endoscopic submucosal dissection (ESD), especially in patients taking antithrombotic agents. The aim of this study was to evaluate the superiority of vonoprazan (VPZ) over proton pump inhibitor (PPI) in preventing delayed bleeding after gastric ESD in patients taking ...
Hiroyuki Shibata   +16 more
wiley   +1 more source

The Use of a Diagonal Photoflow System Combined with a High‐Power UV LED in High‐Speed C─H Bromination Reactions

open access: yesAsian Journal of Organic Chemistry, Volume 14, Issue 7, July 2025.
High‐speed flow C─H bromination with N‐bromosuccinimide (NBS) was achieved by combining a diagonal photoflow reactor (LX‐1) with a high‐power UV LED‐s (365 nm). The reaction was highly efficient with residence times in the second order range (6‐13 s). The gram‐scale synthesis of the antiplatelet agent, ticlopidine, was achieved by photoflow benzylic C ...
Takahide Fukuayma   +4 more
wiley   +1 more source

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