Results 61 to 70 of about 6,879 (152)

CYP2C19 genotype testing for clopidogrel: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI‐PGx)

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 329-347, February 2026.
Clopidogrel, an antiplatelet agent, is currently licensed in the United Kingdom for the prevention and treatment of atherothrombotic events in cerebrovascular disease, coronary artery disease and peripheral arterial disease. Clopidogrel requires metabolic activation by the cytochrome P450 enzyme CYP2C19 to be effective.
Cinzia Dello Russo, Iain Frater, Rebecca Kuruvilla, Stefanie Lip, Hannah O'Neill, Kerry Burke, Vicky Chaplin, Alexander S. F. Doney, Salim Elyas, Nicholas Greaves, Sophie Harding, David Hargroves, Judith Hayward, Dyfrig A. Hughes, Tom A. T. Hughes, Sree Kondapally, Patrick Mok, Aaron Peace, Imran Rafi, Simon Ray, Vicky Stinton, Luigi Venetucci, Munir Pirmohamed   +22 more
wiley   +1 more source

Comparison of the Effects of Omeprazole and Rabeprazole on Ticlopidine Metabolism In Vitro

Journal of Pharmacological Sciences, 2011
.: The thienopyridine derivative ticlopidine (TCL) is an inhibitor of adenosine diphosphate-induced platelet aggregation. Combination therapy with a thienopyridine derivative and aspirin is standard after coronary stenting, although more hemorrhagic ...
Yuichi Kinoshita, Naoki Matsumoto, Minoru Watanabe, Yuko Takeba, Yutoku Yoshida, Keiichiro Ohba, Satoshi Suzuki, Fumio Itoh, Toshio Kumai, Shinichi Kobayashi   +9 more
doaj   +1 more source

A Review on Ginkgo biloba: Nutritional Profile, Toxicity, and Its Therapeutic Potential in Stroke Management

eFood, Volume 7, Issue 1, February 2026.
Stroke is a neurological impairment caused by vascular injury of the central nervous system, and globally, stroke is ranked as the second most common cause of death and disability. Numerous risk factors, disease processes, and mechanisms can contribute to stroke, which is not a single disease. G.
Ali Ikram, Farhang Hameed Awlqadr, Hamna Tayyab, Mamoona Shehzadi, Muhammad Tayyab Arshad, Md. Sakhawot Hossain, Ahmadullah Zahir   +6 more
wiley   +1 more source

2-Chlorophenyl Zinc Bromide: A Convenient Nucleophile for the Mannich-Related Multicomponent Synthesis of Clopidogrel and Ticlopidine

Molecules, 2010
A methodological study devoted to the Mannich-like multicomponent synthesis of the antiplatelet agent (±)‑clopidogrel (7) and the ethyl ester analogue 6 is described.
Isabelle Aillaud, Caroline Haurena, Erwan Le Gall, Gino Ricci, Thierry Martens   +4 more
doaj   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta‐Analysis

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 46-62, January 2026.
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik, Ainhoa Gomez‐Lumbreras, Guilherme Del Fiol, Kensaku Kawamoto, Katy E. Trinkley, Thomas Reese, Aubrey Jones, Daniel C. Malone   +7 more
wiley   +1 more source

Acute Iatrogenic Agranulocytosis: A Rare and Dire Case of an Adverse Drug Reaction to Be Aware

Case Reports in Hematology, 2020
Background. Iatrogenic agranulocytosis (IA), by nonchemotherapeutic drugs, is a rare adverse event, resulting in a neutrophil count under 0.5 × 109 cells/L with fever or other suggestive signs of infection. Methods.
Diogo André, Mónica Caldeira, Fabiana Gouveia, Rafael Nascimento, António Chaves, Maria Brazão   +5 more
doaj   +1 more source

Haemorrhagic shock due to spontaneous splenic haemorrhage complicating antiplatelet therapy: endovascular management

The Egyptian Journal of Internal Medicine, 2015
Spontaneous splenic haemorrahge and rupture is a rare but life-threatening condition requiring urgent diagnosis and treatment. Splenic haemorrhage and rupture precipitated by thrombolytic or antiocoagulant therapy has been reported frequently in the ...
Garge S Shaileshkumar, Keshava N Shyamkumar, Ahmed Munawwar, Purushothaman Vijayan, Perakath Benjamin   +4 more
doaj   +1 more source

Comparative Efficacy and Safety of Different Antiplatelet Agents for Prevention of Major Cardiovascular Events and Leg Amputations in Patients with Peripheral Arterial Disease: A Systematic Review and Network Meta-Analysis.

PLoS ONE, 2015
There is a lack of consensus regarding which type of antiplatelet agent should be used in patients with peripheral arterial disease (PAD) and little is known on the advantages and disadvantages of dual antiplatelet therapy.
Konstantinos Katsanos, Stavros Spiliopoulos, Prakash Saha, Athanasios Diamantopoulos, Narayan Karunanithy, Miltiadis Krokidis, Bijan Modarai, Dimitris Karnabatidis   +7 more
doaj   +1 more source

A better effect of cilostazol for reducing in-stent restenosis after femoropopliteal artery stent placement in comparison with ticlopidine

Medical Devices: Evidence and Research, 2011
Ichiro Ikushima1, Kazuchika Yonenaga1, Hironao Iwakiri2, Hideki Nagoshi2, Haruhito Kumagai2, Yasuyuki Yamashita31Department of Radiology, 2Department of Cardiology, Miyakonojo Medical Association Hospital, Miyakonojo, Japan; 3Department of Diagnostic ...
Ikushima I, Yonenaga K, Iwakiri H, Nagoshi H, Kumagai H, Yamashita Y   +5 more
doaj  

A terapêutica médica da angina de peito.

Acta Médica Portuguesa, 1997
The angina pectoris crisis should be treated with nitroglycerin S.L.. In our days as in the 19th century, the non pharmacological therapeutic approach for angina pectoris (per se and to improve the free interval between crises) is still the same.
J G Clara
doaj   +1 more source