Results 51 to 60 of about 17,202 (220)

The TUBA1B–G3BP2 Axis Sustains p65 Transcriptional Activity to Promote Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin, Hechun Lin, Junming Yu, Chao Ge, Lin Mao, Saihua Zhang, Yizi Jin, Yunyu Wu, Taoyang Chen, Jinjun Li, Hong Li   +10 more
wiley   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Mechanically Robust, Self‐Healable, and Cryotolerant GelMA Hydrogel for Wearable Tactile Sensors with Enhanced Durability, Lifetime, and Environmental Stability

Advanced Science, EarlyView.
A mechanically robust, self‐healable, moisturizing, cryotolerant and adhesive GelMA hydrogel is developed by incorporating polyvinyl alcohol, acrylic acid, sodium tetraborate, and glycerol into GelMA matrix via a photoinitiated polymerization process. The hydrogel‐derived omni‐healable ionotronic pressure sensor can sensitively and consistently monitor
Zhikang Li, Gengyu Han, Boqing Jia, Jijian Lu, Changxu Zhang, Bin Wang, Jiaxiang Wang, Kang Zhao, Muhammad Afzal Khan Qureshi, Lan Yu, Min Li, Guoxi Luo, Tong Wang, Qijing Lin, Weishi Li, Libo Zhao, Yumeng Xue   +16 more
wiley   +1 more source

Change in End-Tidal Co 2 After Mini-Fluid Challenge to Determine Fluid Responsiveness

Critical Care Explorations, 2022
OBJECTIVES:. Distributive shock is a major cause of morbidity and mortality in the ICU. IV fluid resuscitation is a vital intervention to improve cardiac output and end-organ perfusion during the initial resuscitation and for those who remain fluid ...
Isadore M. Budnick, MD, John J. Popovich, MD, Andrew J. Barros, MD, Alexandra Kadl, MD   +3 more
doaj   +1 more source

Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using Hyperpolarized 13C MRI and PET

Advanced Science, EarlyView.
This work presents a clinically deployable simultaneous PET/MRI workflow which integrates hyperpolarized 13C imaging of metabolism and extracellular pH with [18F]FMISO PET to characterize hypoxia, acidosis, and metabolic reprogramming in feline sarcoma.
Martin Grashei, Tanja Groll, Stephanie Kahl, Silke Baer, Elisabeth Bliemsrieder, Frits H. A. van Heijster, Andre Wendlinger, Pascal Wodtke, Jorge Cabello, Susan Notohamiprodjo, Christian Lohrmann, Markus Schwaiger, Wolfgang A. Weber, Katja Steiger, Andrea Meyer‐Lindenberg, Johannes Hirschberger, Christine Baumgartner, Franz Schilling   +17 more
wiley   +1 more source

An experimental model of asthma in rats using ovalbumin and lipopolysaccharide allergens

Heliyon, 2019
Asthma is chronic and multi-factorial inflammatory disease hence single allergen induced asthma in an animal is not identical to clinical asthma.
Vandana R. Thakur, Vikas Khuman, Jayesh V. Beladiya, Kiranj K. Chaudagar, Anita A. Mehta   +4 more
doaj   +1 more source

Assessment of Fluid Responsiveness in Prone Neurosurgical Patients Undergoing Protective Ventilation: Role of Dynamic Indices, Tidal Volume Challenge, and End-Expiratory Occlusion Test

Anesthesia & Analgesia, 2020
BACKGROUND: In patients in the prone position, the reliability of pulse pressure variation and stroke volume variation (PPV and SVV) and the use of functional hemodynamic tests to predict fluid responsiveness have not previously been established.
Messina, Antonio, Montagnini, Claudia, Cammarota, Gianmaria, Giuliani, Fabiana, Muratore, Lara, BAGGIANI, MARTA, Bennett, Victoria, Della Corte, Francesco, Navalesi, Paolo, Cecconi, Maurizio   +9 more
openaire   +4 more sources

Bio‐Inspired Internal Stress Engineering for Microscale Surface Cracking in Sensitive Strain Sensors

Advanced Science, EarlyView.
This study presents a bio‐inspired internal stress engineering strategy to fabricate highly sensitive crack‐based strain sensors. By harnessing the internal expansion energy of microspheres and the thickness‐dependent brittle‐to‐ductile transition of ultrathin gold films, tunable microscale cracks are generated.
Jae Yeong Jang, Hanchul Cho, Young Jung
wiley   +1 more source

Evaluation of volume responsiveness by pulse pressure variability and inferior vena cava dispensability index at different tidal volumes by mechanical ventilation

Brazilian Journal of Medical and Biological Research
This study investigated the effects of tidal volume (TV) on the diagnostic value of pulse pressure variation (PPV) and the inferior vena cava dispensability index (IVC-DI) for volume responsiveness during mechanical ventilation.
Fujuan He, Xiaoqiang Li, Suman Thapa, Chi Li, Jiawei Luo, Wenyan Dai, Jin Liu   +6 more
doaj   +1 more source

Respiratory Volume Monitoring: A Machine-Learning Approach to the Non-Invasive Prediction of Tidal Volume and Minute Ventilation

IEEE Access, 2020
Continuous monitoring of ventilatory parameters such as tidal volume (TV) and minute ventilation (MV) has shown to be effective in the prevention of respiratory compromise events in hospitalized patients.
Daniel E. Hurtado, Javier A. P. Chavez, Roberto Mansilla, Roberto Lopez, Angel Abusleme   +4 more
doaj   +1 more source