Results 171 to 180 of about 30,973 (211)

Preferential activity of Tie2 promoter in arteriolar endothelium [PDF]

Journal of Cellular and Molecular Medicine, 2005
The tyrosine kinase Tie2/Tek (the receptor for angiopoietins) is considered one of the most reliable markers of the endothelial phenotype, across organisms, organs, and developmental stages. However, endothelium is intrinsically heterogeneous in origin, composition and function, presenting an arteriolar/venular asymmetry. In this regard, the expression
Nicanor Moldovan
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Targeting the ANGPT–TIE2 pathway in malignancy

Nature Reviews Cancer, 2010
Angiopoietins (ANGPTs) are ligands of the endothelial cell receptor TIE2 and have crucial roles in the tumour angiogenic switch. Increased expression of ANGPT2 relative to ANGPT1 in tumours correlates with poor prognosis. The biological effects of the ANGPT-TIE system are context dependent, which brings into question what the best strategy is to target
Hanhua, Huang, Abhijit, Bhat, Gary, Woodnutt, Rodney, Lappe   +3 more
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Mechanistic Effects of Autophosphorylation on Receptor Tyrosine Kinase Catalysis:  Enzymatic Characterization of Tie2 and Phospho-Tie2

Biochemistry, 2001
Activation of receptor tyrosine kinases by autophosphorylation is one of the most common and critical transformations in signal transduction, yet its role in catalysis remains controversial. Autophosphorylation of the angiogenic receptor tyrosine kinase Tie2 was studied in terms of the autophosphorylation sites, sequence of phosphorylation at these ...
B W, Murray, E S, Padrique, C, Pinko, M A, McTigue   +3 more
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The First Naturally Occurring Tie2 Kinase Inhibitor

Organic Letters, 2001
[structure: see text] Bioassay-guided fractionation of the plant Acacia aulacocarpa, guided by a bioassay for Tie2 tyrosine kinase activity, yielded the novel triterpene 3,21-dioxo-olean-18-en-oic acid (1) as the first naturally occurring non-protein inhibitor of Tie2 kinase. The structure of 1 was assigned by analysis of spectral data.
B N, Zhou, R K, Johnson, M R, Mattern, P W, Fisher, D G, Kingston   +4 more
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Tek/Tie2 Signaling: New and Old Partners

Cancer and Metastasis Reviews, 2000
A common property amongst angiogenic ligands such as the vascular endothelial growth factors and the angiopoietins is that they can elicit multiple responses depending upon the context of their expression and the presence of other growth factors. Study of the signal transduction pathways initiated by these growth factors provides insight into the ...
N, Jones, D J, Dumont
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Angiopoietins and Tie2 in health and disease.

Pediatric endocrinology reviews : PER, 2006
The angiopoietins are a class of growth factors that activate the Tie2 receptor and play important roles in the regulation of angiogenesis. Proper regulation of angiogenesis is required for both embryonic vascular development and physiological processes in the adult such as wound healing and the female reproductive cycle, while aberrant regulation of ...
Lu-Yuan, Li, Keith D, Barlow, Linda J, Metheny-Barlow   +2 more
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Targeting Tie2 and the host vascular response in sepsis

Science Translational Medicine, 2016
A new therapeutic approach to a complex and dire disease—sepsis—targets a signaling molecule in the vasculature (Han et al ., this issue).
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Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination

Cancers, 2021
John Condeelis, Lucia Borriello, Camille Duran   +2 more
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Less restriction for TIE2

Nature Reviews Cancer, 2005
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Role of the Ets Transcription Factors in the Regulation of the Vascular-Specific Tie2 Gene

Circulation Research, 1999
Towia Libermann, Peter Oettgen, Yasmin Akbarali   +2 more
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