Results 161 to 170 of about 30,973 (211)
Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases. [PDF]
Agarwal S, Bankar A, de Jesus Perez VA.
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HIF-1α/Netrin-4 Axis Mediates RIPC-Induced Angiogenesis and Neurogenesis After Ischemic Stroke. [PDF]
Feng Z +9 more
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Endogenous Amphiregulin promotes muscle repair and function through expansion of fibro-adipogenic progenitors during chronic <i>Toxoplasma gondii</i> infection in mice. [PDF]
Shihab R +4 more
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Vaccination against TIE2 reduces atherosclerosis
Atherosclerosis, 2009TIE2(+) cells play a crucial role in processes that are involved in atherosclerosis, such as angiogenesis. Therefore, the specific deletion of TIE2(+) cells by means of DNA vaccination may affect atherosclerosis.Cellular immunity against cells that overexpress TIE2 was established in LDLr(-/-) mice by a novel oral DNA vaccination technique, in which an
Theo van Berkel +2 more
exaly +3 more sources
Pyridinylimidazole inhibitors of Tie2 kinase
Bioorganic and Medicinal Chemistry Letters, 2007This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.
Neil Johnson
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Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2–Tie2 complex
Nature Structural & Molecular Biology, 2006The Tie receptor tyrosine kinases and their angiopoietin (Ang) ligands play central roles in developmental and tumor-induced angiogenesis. Here we present the crystal structures of the Tie2 ligand-binding region alone and in complex with Ang2. In contrast to prediction, Tie2 contains not two but three immunoglobulin (Ig) domains, which fold together ...
William A, Barton +6 more
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VEGF Induces Tie2 Shedding via a Phosphoinositide 3-Kinase/Akt–Dependent Pathway to Modulate Tie2 Signaling [PDF]
Objective— Tie2 and its ligands, the angiopoietins (Ang), are required for embryonic and postnatal angiogenesis. Previous studies have demonstrated that Tie2 is proteolytically cleaved, resulting in the production of a 75-kDa soluble receptor fragment (sTie2).
Christopher Kontos, Asif Ahmed
exaly +3 more sources

