Results 161 to 170 of about 30,973 (211)

HIF-1α/Netrin-4 Axis Mediates RIPC-Induced Angiogenesis and Neurogenesis After Ischemic Stroke. [PDF]

open access: yesJ Cell Mol Med
Feng Z   +9 more
europepmc   +1 more source
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Vaccination against TIE2 reduces atherosclerosis

Atherosclerosis, 2009
TIE2(+) cells play a crucial role in processes that are involved in atherosclerosis, such as angiogenesis. Therefore, the specific deletion of TIE2(+) cells by means of DNA vaccination may affect atherosclerosis.Cellular immunity against cells that overexpress TIE2 was established in LDLr(-/-) mice by a novel oral DNA vaccination technique, in which an
Theo van Berkel   +2 more
exaly   +3 more sources

Pyridinylimidazole inhibitors of Tie2 kinase

Bioorganic and Medicinal Chemistry Letters, 2007
This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.
Neil Johnson
exaly   +3 more sources

Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2–Tie2 complex

Nature Structural & Molecular Biology, 2006
The Tie receptor tyrosine kinases and their angiopoietin (Ang) ligands play central roles in developmental and tumor-induced angiogenesis. Here we present the crystal structures of the Tie2 ligand-binding region alone and in complex with Ang2. In contrast to prediction, Tie2 contains not two but three immunoglobulin (Ig) domains, which fold together ...
William A, Barton   +6 more
openaire   +2 more sources

VEGF Induces Tie2 Shedding via a Phosphoinositide 3-Kinase/Akt–Dependent Pathway to Modulate Tie2 Signaling [PDF]

open access: yesArteriosclerosis, Thrombosis, and Vascular Biology, 2007
Objective— Tie2 and its ligands, the angiopoietins (Ang), are required for embryonic and postnatal angiogenesis. Previous studies have demonstrated that Tie2 is proteolytically cleaved, resulting in the production of a 75-kDa soluble receptor fragment (sTie2).
Christopher Kontos, Asif Ahmed
exaly   +3 more sources

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