Results 141 to 150 of about 33,818 (248)

Coactivation of Tie2 and Wnt signaling using an antibody–R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia

mAbs
Therapeutic angiogenesis by intentional formation of blood vessels is essential for treating various ischemic diseases, including limb ischemia. Because Wnt/β-catenin and angiopoietin-1/Tie2 signaling play important roles in endothelial survival and ...
Byungtae Hwang, Min-Young Jeon, Ju-Hong Jang, Young-Lai Cho, Dong Gwang Lee, Jeong-Ki Min, Jangwook Lee, Jong-Gil Park, Ji-Hun Noh, Wonjun Yang, Nam-Kyung Lee   +10 more
doaj   +1 more source

Single‐Cell RNA‐Seq Combined With Bulk RNA‐Seq Revealed the Involvement of Pancreatic Cancer Tissue‐Resident Macrophages in Tumour Progression and the Immunotherapy Response

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Pancreatic cancer remains a highly lethal malignancy with limited therapeutic efficacy and untapped immunotherapeutic potential, largely constrained by immune cell heterogeneity in the tumour microenvironment. Tumour‐associated macrophages (TAMs), especially tissue‐resident macrophages (TRMs), exert complex regulatory roles in tumour ...
Bin Wu, Chundong Hu, Fengchun Lu
wiley   +1 more source

Can PPARδ agonist increase cell yield of nucleus pulposus progenitor cells positive for angiopoietin-1 receptor (= TIE2) after cell isolation?

, 2019
Introduction: Nucleus pulposus progenitor cells (NPPC), Tie2+ cells (positive for angiopoietin receptor), which possess multi-lineage differential potential is a potential cell population for cell therapy.
Benneker, Lorin M., Gantenbein, Benjamin, Sakai, Daisuke, May, Rahel D., Frauchiger, Daniela A., Dzafo, Emina, Zhang, Xingshuo, Tekari, Adel, Tryfonidou, Marianna   +8 more
core  

Roles of angiopoietin and TIE2 receptor angiogenesis

Ensho Saisei, 2001
Vascular development consists of two processes termed vasculogenesis and angiogenesis. The system of TIE 2-Angiopoietin (Ang) is involved in the later, angiogenesis. It has been demonstrated that the function of TIE 2 is associated with adhesion and dissociation between endothelial cells and mural cells, and survival, apoptosis, and chemotaxis of ...
openaire   +1 more source

Identification and characterization of small‐molecule inhibitors of Tie2 kinase

FEBS Letters, 2008
Angiopoietins and Tie2 receptor were recently identified as an endothelial cell‐specific ligand‐receptor system that is critical for vascular development and postnatal pathologic angiogenesis by mediating vascular integrity. In this study, we identified a series of small‐molecule Tie2 inhibitors, which blocked Ang1‐induced Tie2 autophosphorylation and ...
Liu, Jinqi, Lin, Tsung H., Cole, Andrew G., Wen, Rong, Zhao, Lian, Brescia, Marc-Raleigh, Jacob, Biji, Hussain, Zahid, Appell, Kenneth C., Henderson, Ian, Webb, Maria L.   +10 more
openaire   +2 more sources

Effects of VEGF, PMA and TNFá on Cellular Tie2 Activation.

, 2013
HUVEC were treated with VEGF A, PMA B or TNFα C for 0, 0.5 or 24 h to induce Tie1 and Tie2 ectodomain cleavage followed by 200 ng/ml Ang1 for 30 min.
Tania M. Hansen (336147), Nicholas P. J. Brindle (336149), Harprit Singh (336144), Nisha Patel (336148)   +3 more
core   +1 more source

The selective Tie2 inhibitor rebastinib blocks recruitment and function of Tie2Hi macrophages in breast cancer and pancreatic neuroendocrine tumors

Molecular Cancer Therapeutics, 2017
Tumor-infiltrating myeloid cells promote tumor progression by mediating angiogenesis, tumor cell intravasation, and metastasis, which can offset the effects of chemotherapy, radiation, and antiangiogenic therapy.
A. S. Harney, G. Karagiannis, Jeanine Pignatelli, Bryan D. Smith, E. Kadioglu, S. Wise, Molly M. Hood, Michael D. Kaufman, Cynthia Leary, Weiping Lu, Gada K. Al-Ani, Xiaoming Chen, D. Entenberg, M. Oktay, Yarong Wang, Lawrence Chun, Michele De Palma, Joan G. Jones, D. Flynn, J. Condeelis   +19 more
semanticscholar   +1 more source

안구 혈관 질환에서 Angiopoietin-Tie2 신호전달체계의 역할

, 2018
학위논문(박사) - 한국과학기술원 : 의과학대학원, 2018.2,[v, 128 p. :]Part I. Role of Angiopoietin-Tie2 System in Schlemm’s Canal Integrity and Glaucomagenesis Elevated intraocular pressure (IOP) because of increased resistance to aqueous humor outflow (AHO) is a main cause ...
Jaeryung, Kim
core  

The Tie2 RTK: Regulation and Downstream Signaling

, 2010
Tie2 is a receptor tyrosine kinase (RTK) involved in numerous aspects of both normal and pathological angiogenesis. Proper functioning of this receptor is essential for normal development of the vasculature in the embryo as well as vessel maintenance ...
Sturk, Celina Marie
core   +1 more source

Structure of the Tie2 RTK Domain [PDF]

Structure, 2000
Shewchuk, Lisa M, Hassell, Anne M, Ellis, Byron, Holmes, W.D, Davis, Roderick, Horne, Earnest L, Kadwell, Sue H, McKee, David D, Moore, John T   +8 more
openaire   +1 more source