Results 141 to 150 of about 27,290 (180)

Targeting the ANGPT–TIE2 pathway in malignancy

Nature Reviews Cancer, 2010
Angiopoietins (ANGPTs) are ligands of the endothelial cell receptor TIE2 and have crucial roles in the tumour angiogenic switch. Increased expression of ANGPT2 relative to ANGPT1 in tumours correlates with poor prognosis. The biological effects of the ANGPT-TIE system are context dependent, which brings into question what the best strategy is to target
Hanhua, Huang, Abhijit, Bhat, Gary, Woodnutt, Rodney, Lappe   +3 more
openaire   +2 more sources

The flow dependency of Tie2 expression in endotoxemia

Intensive Care Medicine, 2013
Tie2 is predominantly expressed by endothelial cells and is involved in vascular integrity control during sepsis. Changes in Tie2 expression during sepsis development may contribute to microvascular dysfunction. Understanding the kinetics and molecular basis of these changes may assist in the development of therapeutic intervention to counteract ...
Kurniati, Neng F., Jongman, Rianne M., vom Hagen, Franziska, Spokes, Katherine C., Moser, Jill, Regan, Erzsebet Ravasz, Krenning, Guido, Moonen, Jan-Renier A. J., Harmsen, Martin C., Struys, Michel M. R. F., Hammes, Hans-Peter, Zijlstra, Jan G., Aird, William C., Heeringa, Peter, Molema, Grietje, van Meurs, Matijs   +15 more
openaire   +3 more sources

Mechanistic Effects of Autophosphorylation on Receptor Tyrosine Kinase Catalysis:  Enzymatic Characterization of Tie2 and Phospho-Tie2

Biochemistry, 2001
Activation of receptor tyrosine kinases by autophosphorylation is one of the most common and critical transformations in signal transduction, yet its role in catalysis remains controversial. Autophosphorylation of the angiogenic receptor tyrosine kinase Tie2 was studied in terms of the autophosphorylation sites, sequence of phosphorylation at these ...
B W, Murray, E S, Padrique, C, Pinko, M A, McTigue   +3 more
openaire   +2 more sources

Tek/Tie2 Signaling: New and Old Partners

Cancer and Metastasis Reviews, 2000
A common property amongst angiogenic ligands such as the vascular endothelial growth factors and the angiopoietins is that they can elicit multiple responses depending upon the context of their expression and the presence of other growth factors. Study of the signal transduction pathways initiated by these growth factors provides insight into the ...
N, Jones, D J, Dumont
openaire   +2 more sources

The First Naturally Occurring Tie2 Kinase Inhibitor

Organic Letters, 2001
[structure: see text] Bioassay-guided fractionation of the plant Acacia aulacocarpa, guided by a bioassay for Tie2 tyrosine kinase activity, yielded the novel triterpene 3,21-dioxo-olean-18-en-oic acid (1) as the first naturally occurring non-protein inhibitor of Tie2 kinase. The structure of 1 was assigned by analysis of spectral data.
B N, Zhou, R K, Johnson, M R, Mattern, P W, Fisher, D G, Kingston   +4 more
openaire   +2 more sources

Angiopoietins and Tie2 in health and disease.

Pediatric endocrinology reviews : PER, 2006
The angiopoietins are a class of growth factors that activate the Tie2 receptor and play important roles in the regulation of angiogenesis. Proper regulation of angiogenesis is required for both embryonic vascular development and physiological processes in the adult such as wound healing and the female reproductive cycle, while aberrant regulation of ...
Lu-Yuan, Li, Keith D, Barlow, Linda J, Metheny-Barlow   +2 more
openaire   +1 more source

Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination

Cancers, 2021
John Condeelis, Lucia Borriello, Camille Duran   +2 more
exaly  

VEGF Induces Tie2 Shedding via a Phosphoinositide 3-Kinase/Akt–Dependent Pathway to Modulate Tie2 Signaling

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Christopher Kontos, Asif Ahmed
exaly  

Role of the Ets Transcription Factors in the Regulation of the Vascular-Specific Tie2 Gene

Circulation Research, 1999
Towia Libermann, Peter Oettgen, Yasmin Akbarali   +2 more
exaly  

Less restriction for TIE2

Nature Reviews Cancer, 2005
openaire   +1 more source