Results 121 to 130 of about 33,818 (248)

Spheroid-Like Cultures for Expanding Angiopoietin Receptor-1 (aka. Tie2) Positive Cells from the Human Intervertebral Disc. [PDF]

, 2020
Lower back pain is a leading cause of disability worldwide. The recovery of nucleus pulposus (NP) progenitor cells (NPPCs) from the intervertebral disc (IVD) holds high promise for future cell therapy.
Guerrero, Julien, Benjamin Gantenbein, Gantenbein, Benjamin, Croft, Andreas S., Albers, Christoph E., Xingshuo Zhang, Andreas S. Croft, Sonja Häckel, Zhang, Xingshuo, Häckel, Sonja, Julien Guerrero, Christoph E. Albers   +11 more
core   +1 more source

EphA4/Tie2 crosstalk regulates leptomeningeal collateral remodeling following ischemic stroke.

Journal of Clinical Investigation, 2020
Leptomeningeal anastomoses or pial collateral vessels play a critical role in cerebral blood flow (CBF) restoration following ischemic stroke. The magnitude of this adaptive response is postulated to be controlled by the endothelium, although the ...
Benjamin Okyere, William A Mills, Xia Wang, Michael Chen, Jiang Chen, A. Házy, Yun Qian, John B. Matson, M. Theus   +8 more
semanticscholar   +1 more source

Characterization of Tie2 signalling during acute inflammation

, 2018
The inflammatory response is essential for the eradication of lipopolysaccharide (LPS) presenting microbial invaders. However, resolution is also important to prevent detrimental vascular inflammation to the host.
Smith, Tracy Lauren
core   +1 more source

On the Origin of the Brain Semi‐Heavy Water Deuterium MR Signal Following Administration of Deuterated Metabolic Substrate: A Cautionary Tale

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 862-870, August 2026.
ABSTRACT Purpose To evaluate the extent to which the appearance of HOD in the brain following systemic administration of a deuterated substrate is due to local brain metabolism versus body metabolism. Methods [6,6‐2H2]glucose, which is transported across the blood‐brain barrier (BBB), and [6,6‐2H2]fructose (Fruc), which does not cross the BBB, were ...
Joseph J. H. Ackerman, Xia Ge, Nick Rensing, Jeffrey J. Neil, Liu Lin Thio, Joel R. Garbow   +5 more
wiley   +1 more source

Dimerization of Tie2 mediated by its membrane-proximal FNIII domains

, 2017
Significance Tie2 is a receptor tyrosine kinase with important roles in vascular development. Inhibiting Tie2 may impair tumor angiogenesis, whereas activating Tie2 may be beneficial in sepsis and inflammation. To modulate Tie2 therapeutically,
Mark A. Lemmon, Jason O. Moore, Kathryn M. Ferguson   +2 more
core   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, Volume 36, Issue 4, July 2026.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Beyond Hemostasis: Platelet Biomarkers and Vascular‐Immune Crosstalk in Dengue

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Several biomarkers are associated with platelet activation during dengue virus (DENV) infection. These include serum markers (AST, ALT, ferritin), platelet surface or secreted molecules (P‐selectin, PF4, RANTES, VEGF‐A, CD40L, TREM‐1, TLT‐1), immune and endothelial markers (TREM‐1, Ang‐1, Ang‐2), and viral components such as DENV EIII.
Amanda Beatriz Adriano da Silva‐Alencar, Amanda de Oliveira Matos, Daniel Francisco de Sousa, Jefferson do Carmo Dietz, Eugenio Damaceno Hottz, Marcelle Figueira Marques da Silva‐Sales, Helioswilton Sales‐Campos   +6 more
wiley   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Kinetics of Tie1 and Tie2 Cleavage.

, 2013
A Tie2 extracellular domain is released from endothelial cells. HUVEC were untreated or stimulated with 10 ng/ml PMA for 24 h, as indicated, before collection of culture medium, removal of cellular material by centrifugation and immunoprecipitation of ...
Tania M. Hansen (336147), Nicholas P. J. Brindle (336149), Harprit Singh (336144), Nisha Patel (336148)   +3 more
core   +1 more source

The VALTIVE1 study protocol: a study for the validation of Tie2 as the first tumour vascular response biomarker for VEGF inhibitors

BMC Cancer
Background Anti-angiogenic, VEGF inhibitors (VEGFi) increase progression-free survival (PFS) and, in some cases, overall survival in many solid tumours. However, their use has been compromised by a lack of informative biomarkers.
Margherita Carucci, Andrew Clamp, Cong Zhou, Chris Hurt, Rosalind Glasspool, Phillip J. Monaghan, Sally Thirkettle, Michael Wheatley, Madia Mahmood, Monica Narasimham, Tracy Cox, Hilary Morrison, Susan Campbell, Annmarie Nelson, Daniella Holland-Hart, Noreen Hopewell-Kelly, Abin Thomas, Catharine Porter, Magdalena Slusarczyk, Alys Irving, Caroline Dive, Richard Adams, Gordon C. Jayson   +22 more
doaj   +1 more source