Results 101 to 110 of about 30,973 (211)

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

, 2023
Leukocytes and resident cells in the arterial wall contribute to atherosclerosis, especially at sites of disturbed blood flow. Expression of endothelial Tie1 receptor tyrosine kinase is enhanced at these sites, and attenuation of its expression reduces ...
Öörni, Katariina, Kaikkonen, Minna U., Fang, Shentong, Singha, Prosanta, Alitalo, Kari, Anisimov, Andrey, Chevre, Raphael, Karaman, Sinem, Korhonen, Emilia A., Soehnlein, Oliver, Örd, Tiit, Gilani, Huda, van Avondt, Kristof, Hemanthakumar, Karthik Amudhala, Nguyen, Su D., Augustin, Hellmut G., Toropainen, Anu, Adams, Ralf H.   +17 more
core   +1 more source

Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

, 2017
The Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed endothelial-specific expression. Yet, Tie2 is also expressed at lower levels by pericytes and it has
Arne Bartol, Katharina Schlereth, Stella Hertel, Zulfiyya Hasanov, Soniya Savant, Kshitij Srivastava, Laura Milde, Tina Ruckdeschel, Nicolas Gengenbacher, Hellmut G. Augustin, Annegret Holm, Junhao Hu, Martin Teichert, Laura Stanicek   +13 more
core   +1 more source

PHD2 regulates arteriogenic macrophages through TIE2 signaling [PDF]

, 2013
Occlusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype ...
Alexander Hamm, Mazzone, Max, Yukiji Takeda, Carmen Roncal, Alitalo, Kari, Pucci, Ferdinando, Sandra Costa, Veschini, Lorenzo, Delamarre, Estelle, Mazzone, M., Squadrito, Mario Leonardo, Henze, Anne-Theres, Hamm, Alexander, Mario Leonardo Squadrito, Mathias Wenes, Estelle Delamarre, Ferdinando Pucci, Costa, Sandra Maria Araújo da, De Palma, M., Veschini, Lorenzo; id_orcid, Kari Alitalo, Andrey Anisimov, Massimiliano Mazzone, Mazzone, Massimiliano, Anisimov, Andrey, Takeda, Yukiji, Wenes, Mathias, Costa, Sandra, Serneels, Jens, Lorenzo Veschini, De Palma, Michele, Anne‐Theres Henze, Jens Serneels, Roncal, Carmen, Michele De Palma   +34 more
core   +2 more sources

Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment

Scientific Reports, 2019
Abnormalities in controlling key aspects of angiogenesis including vascular cell migration, lumen formation and vessel maturation are hallmarks of vascular anomalies including venous malformation (VM).
Yuqi Cai, Sandra Schrenk, Jillian Goines, George E. Davis, Elisa Boscolo   +4 more
doaj   +1 more source

A comparative analysis of tie2-positive IVD progenitor cells in single-cell and bulk transcriptomics. [PDF]

Introduction: Back pain and disability are often attributed to intervertebral disc (IVD) degeneration1, where current treatments are limited by an incomplete understanding of IVD biology.
Stirnimann, Anja, Schlagenhof, Leon Max, Gantenbein, Benjamin, Ille, F.   +3 more
core   +1 more source

Kinetics of Tie1 and Tie2 Cleavage.

, 2013
A Tie2 extracellular domain is released from endothelial cells. HUVEC were untreated or stimulated with 10 ng/ml PMA for 24 h, as indicated, before collection of culture medium, removal of cellular material by centrifugation and immunoprecipitation of ...
Tania M. Hansen (336147), Nicholas P. J. Brindle (336149), Harprit Singh (336144), Nisha Patel (336148)   +3 more
core   +1 more source

Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination. [PDF]

, 2011
Cytomegalovirus (CMV) is frequently transmitted by solid organ transplantation and is associated with graft failure. By forming the boundary between circulation and organ parenchyma, endothelial cells (EC) are suited for bidirectional virus spread from ...
Jauch, Karl-Walter, Sacher, Torsten, Lars Dölken, Aivars Kalnins, Matthias J Reddehase, Ulrich H Koszinowski, Koszinowski, Ulrich H., Zsolt Ruzsics, Podlech, Jürgen, Karl-Walter Jauch, Ruzsics, Zsolt, Andrassy, Joachim, Dölken, Lars, Joachim Andrassy, Matthias J. Reddehase, Jordan, Stefan, Ulrich H. Koszinowski, Reddehase, Matthias J., Stefan Jordan, Kalnins, Aivars, Torsten Sacher, Jürgen Podlech   +21 more
core   +2 more sources

Tie2 receptor와 Angiopoietin 복합체의 결정화에 관한 연구

, 2007
학위논문(석사) - 한국과학기술원 : 화학과, 2007.2, [ vi, 50 p. ]The receptor tyrosine kinases, tie1 and tie2, which is largely endothelial cell specific, and angiopoietin-1, 2, secreted ligand for tie2, are recently discovered to be critically involved in the ...
김지원, Kim, Ji-Won
core   +1 more source

Functional Significance of Tie2 Signaling in the Adult Vasculature

Recent Progress in Hormone Research, 2004
Abundant data now demonstrate that the growth of new blood vessels, termed angiogenesis, plays both pathological and beneficial roles in human disease. Based on these data, a tremendous effort has been undertaken to understand the molecular mechanisms that drive blood vessel growth in adult tissues.
Kevin G, Peters, Christopher D, Kontos, P Charles, Lin, Adrianne L, Wong, Prema, Rao, Liwen, Huang, Mark W, Dewhirst, Sabita, Sankar   +7 more
openaire   +2 more sources

Coactivation of Tie2 and Wnt signaling using an antibody–R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia

mAbs
Therapeutic angiogenesis by intentional formation of blood vessels is essential for treating various ischemic diseases, including limb ischemia. Because Wnt/β-catenin and angiopoietin-1/Tie2 signaling play important roles in endothelial survival and ...
Byungtae Hwang, Min-Young Jeon, Ju-Hong Jang, Young-Lai Cho, Dong Gwang Lee, Jeong-Ki Min, Jangwook Lee, Jong-Gil Park, Ji-Hun Noh, Wonjun Yang, Nam-Kyung Lee   +10 more
doaj   +1 more source