Results 81 to 90 of about 33,818 (248)

Expression patterns of Tie2 protein in organs of control and Tie2 knockout mice.

, 2022
Tie2 protein was detected by immunohistochemistry in organs of Tie2fl/fl/Cre- control mice and Tie2ΔE9 knockout mice after tamoxifen treatment. (A) Photomicrographs of Tie2 staining, taken at 200x optical magnification, on the left.
Peter J. Zwiers (7510744), Radu V. Stan (12837195), Joachim R. Göthert (12837198), Jill Moser (4950721), Grietje Molema (64356), Matijs van Meurs (358888), Rianne M. Jongman (12837192), Timara Kuiper (7510746), Eliane R. Popa (2295178)   +8 more
core   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Deficiency in the p110α subunit of PI3K results in diminished Tie2 expression and Tie2-/-–like vascular defects in mice

Blood, 2005
AbstractPhosphoinositide 3-kinase (PI3K) is activated by transmembrane tyrosine kinases such as vascular endothelial growth factor (VEGF) receptors and Tie2 (tunica intima endothelial kinase 2), both of which are key regulators of vascular development. However, the in vivo role of PI3K during developmental vascularization remains to be defined. Here we
Etienne, Lelievre, Pierre-Marie, Bourbon, Li-Juan, Duan, Robert L, Nussbaum, Guo-Hua, Fong   +4 more
openaire   +3 more sources

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Tie2 (to) Abl: Signaling to endothelial cell survival [PDF]

Cell Cycle, 2013
The vasculature plays a crucial role in normal physiology, supplying oxygen and nutrients, as well as maintaining a semi-permeable barrier between tissues and the bloodstream. Endothelial cells (ECs), which form the innermost lining of blood vessels, are critical players in vascular function, by regulating the transport of solutes and immune cells into
Chislock, Elizabeth M, Pendergast, Ann Marie   +1 more
openaire   +2 more sources

An engineered tetra-valent antibody fully activates the Tie2 receptor with comparable potency to its natural ligand angiopoietin-1

Scientific Reports, 2021
Activation of the tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2) receptor by angiopoietin-1 (Ang1) is critical for vascular stabilization: it promotes survival signal transduction via auto-phosphorylation and reduces ...
Yukari Koya, Hiromi Nara, Shigenori Yagi, Chihoko Ueno, Masazumi Kamohara   +4 more
doaj   +1 more source

Tie2 regulates endocardial sprouting and myocardial trabeculation

JCI Insight, 2019
The ang1-Tie2 pathway is required for normal vascular development, but its molecular effectors are not well-defined during cardiac ontogeny. Here we show that endocardial specific attenuation of Tie2 results in mid-gestation lethality due to heart defects associated with a hyperplastic but simplified trabecular meshwork (fewer but thicker trabeculae ...
Xianghu, Qu, Cristina, Harmelink, H Scott, Baldwin   +2 more
openaire   +2 more sources

Caracterización del eje ANGPT1 / TIE2 en la dormancia de las células cancerosas

, 2020
After arriving in bone, cancer cells can enter a dormancy state that can last for years, during which they are resistant to treatment. The bone microenvironment induces dormancy via mechanisms similar to the ones of hematopoietic stem cells (HSC).
FLORIAN CHRISTOF LAURENZ DRESCHER
core  

C16 Peptide Promotes Vascular Growth and Reduces Inflammation in a Neuromyelitis Optica Model

Frontiers in Pharmacology, 2019
The goal of this study was to elucidate the mechanism of action of C16, a laminin-1 peptide that competes with αvβ3 for integrin binding, in treating neuromyelitis optica (NMO).
Haohao Chen, Xiaoxiao Fu, Jinzhan Jiang, Shu Han   +3 more
doaj   +1 more source