Results 81 to 90 of about 27,290 (180)

On the Origin of the Brain Semi‐Heavy Water Deuterium MR Signal Following Administration of Deuterated Metabolic Substrate: A Cautionary Tale

Magnetic Resonance in Medicine, Volume 96, Issue 2, Page 862-870, August 2026.
ABSTRACT Purpose To evaluate the extent to which the appearance of HOD in the brain following systemic administration of a deuterated substrate is due to local brain metabolism versus body metabolism. Methods [6,6‐2H2]glucose, which is transported across the blood‐brain barrier (BBB), and [6,6‐2H2]fructose (Fruc), which does not cross the BBB, were ...
Joseph J. H. Ackerman, Xia Ge, Nick Rensing, Jeffrey J. Neil, Liu Lin Thio, Joel R. Garbow   +5 more
wiley   +1 more source

Functional Significance of Tie2 Signaling in the Adult Vasculature

Recent Progress in Hormone Research, 2004
Abundant data now demonstrate that the growth of new blood vessels, termed angiogenesis, plays both pathological and beneficial roles in human disease. Based on these data, a tremendous effort has been undertaken to understand the molecular mechanisms that drive blood vessel growth in adult tissues.
Kevin G, Peters, Christopher D, Kontos, P Charles, Lin, Adrianne L, Wong, Prema, Rao, Liwen, Huang, Mark W, Dewhirst, Sabita, Sankar   +7 more
openaire   +2 more sources

HAPLOINSUFFICIENCY OF TIE2 IN MUTATED BLOOD CELLS SUPPRESS ANGIOGENESIS IN THE BONE MARROW AND INHIBIT PROGRESSION OF MDS

Leukemia Research Reports
Introduction: Tie2 is a receptor tyrosine kinase and regulates angiogenesis and vascular quiescence. Given that Tie2 modulates microvascular density in cancer, we hypothesized that deletion of Tie2 in blood cells can inhibit progression of ...
M. Hirayama, Y. Arima, T. Suda, G. Sashida   +3 more
doaj   +1 more source

Endothelial AGGF1 Deficiency Causes Mitochondrial Dysfunction and Contributes to Age‐Elevated Blood Pressure

Aging Cell, Volume 25, Issue 8, August 2026.
Endothelial AGGF1 deficiency contributes to early vascular aging and age‐elevated blood pressure via inhibiting the SESN2/p‐eNOS pathway. Age‐dependent AGGF1 attenuation reduces its binding to the SESN2 promoter. SESN2 downregulation induces mitochondrial respiratory dysfunction and elevated mitochondrial ROS, thereby reducing eNOS phosphorylation ...
Weixin Lv, Xiaojuan Zhong, Qiang Yuan, Xueting Gong, Ya Zhao, Shilin Zhang, Andong Wu, Ming Wan, Xueer Li, Yangyi Zheng, Jiankun Liu, Bingbing Zhou, Yuanzheng Zhu, Limin Zhao, Qiquan Wang, Yang Xiang, Xiao‐Li Tian   +16 more
wiley   +1 more source

The Angiopoietin-Tie2 Signaling Axis in Systemic Inflammation [PDF]

Journal of the American Society of Nephrology, 2017
Systemic inflammation is a hallmark of commonly encountered diseases ranging from bacterial sepsis to sterile syndromes such as major trauma. Derangements in the host vasculature contribute to the cardinal manifestations of sepsis in profound ways. Recent studies of control pathways regulating the vascular endothelium have illuminated how this single ...
openaire   +2 more sources

Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment

Scientific Reports, 2019
Abnormalities in controlling key aspects of angiogenesis including vascular cell migration, lumen formation and vessel maturation are hallmarks of vascular anomalies including venous malformation (VM).
Yuqi Cai, Sandra Schrenk, Jillian Goines, George E. Davis, Elisa Boscolo   +4 more
doaj   +1 more source

Coactivation of Tie2 and Wnt signaling using an antibody–R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia

mAbs
Therapeutic angiogenesis by intentional formation of blood vessels is essential for treating various ischemic diseases, including limb ischemia. Because Wnt/β-catenin and angiopoietin-1/Tie2 signaling play important roles in endothelial survival and ...
Byungtae Hwang, Min-Young Jeon, Ju-Hong Jang, Young-Lai Cho, Dong Gwang Lee, Jeong-Ki Min, Jangwook Lee, Jong-Gil Park, Ji-Hun Noh, Wonjun Yang, Nam-Kyung Lee   +10 more
doaj   +1 more source

A novel Tie2xVEGF bispecific antibody fusion demonstrates enhanced therapeutic efficacy through direct Tie2 activation and VEGF neutralization

Journal of Translational Medicine
Background Activation of endothelial Tie2 signaling has emerged as a potential therapeutic strategy for ameliorating vascular abnormalities and hyperpermeability in ocular diseases.
Min-Gi Kwon, Soo Jin Kim, Kangmin Lee, Jin-Hoi Song, Jaemin Lee, Injune Kim, Jeong-Ki Min, Young-Guen Kwon, Dong Gwang Lee, Junyeop Lee, Nam-Kyung Lee   +10 more
doaj   +1 more source

Roles of angiopoietin and TIE2 receptor angiogenesis

Ensho Saisei, 2001
Vascular development consists of two processes termed vasculogenesis and angiogenesis. The system of TIE 2-Angiopoietin (Ang) is involved in the later, angiogenesis. It has been demonstrated that the function of TIE 2 is associated with adhesion and dissociation between endothelial cells and mural cells, and survival, apoptosis, and chemotaxis of ...
openaire   +1 more source

Structure of the Tie2 RTK Domain [PDF]

Structure, 2000
Shewchuk, Lisa M, Hassell, Anne M, Ellis, Byron, Holmes, W.D, Davis, Roderick, Horne, Earnest L, Kadwell, Sue H, McKee, David D, Moore, John T   +8 more
openaire   +1 more source