Results 71 to 80 of about 30,973 (211)
Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. [PDF]
PLoS ONE, 2011 Development of the hematopoietic and endothelial lineages derives from a common mesodermal precursor, the Flk1(+) hemangioblast. However, the signaling pathways that regulate the development of hematopoietic and endothelial cells from this common ...
Xuehui Yang, Yan Gong, Robert Friesel
doaj +1 more source
International Journal of Cancer, Volume 159, Issue 8, Page 2075-2083, 15 October 2026.Bevacizumab added to systemic chemotherapy remains a cornerstone of metastatic colorectal cancer treatment, but its effectiveness is variable. Tumors can bypass the VEGF blockade by activating other pro‐angiogenic pathways, hampering the identification of predictive biomarkers.
Büsra Akay Hacan +9 more
wiley +1 more source
Detection of Tie2 Cell-Associated Endodomain.
, 2013 A Cells were incubated with PMA for the times indicated in hours before cell lysis and detection of cellular Tie1 endodomain by immunoblotting with an antibody recognizing Tie1 carboxy-terminus, as indicated.
Tania M. Hansen (336147) +3 more
core +1 more source
Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis. [PDF]
PLoS ONE, 2016 Primary myelofibrosis (PMF) is a Philadelphia-negative (Ph-) myeloproliferative disorder, showing abnormal CD34+ progenitor cell trafficking, splenomegaly, marrow fibrosis leading to extensive extramedullary haematopoiesis, and abnormal neoangiogenesis ...
Rita Campanelli +17 more
doaj +1 more source
International Journal of Cancer, Volume 159, Issue 6, Page 1411-1419, 15 September 2026.Although tyrosine kinase inhibitors (TKIs) improve chronic myeloid leukemia (CML) outcome, long‐term effects remain unclear, particularly in real‐world settings. Here, the authors examined morbidity and mortality in CML patients treated with TKIs between 2009 and 2019 in the United Kingdom.
Eleanor Kane +7 more
wiley +1 more source
Expression patterns of Tie2 protein in organs of control and Tie2 knockout mice.
, 2022 Tie2 protein was detected by immunohistochemistry in organs of Tie2fl/fl/Cre- control mice and Tie2ΔE9 knockout mice after tamoxifen treatment. (A) Photomicrographs of Tie2 staining, taken at 200x optical magnification, on the left.
Peter J. Zwiers (7510744) +8 more
core +1 more source
The Tie2 RTK: Regulation and Downstream Signaling [PDF]
, 2010 Tie2 is a receptor tyrosine kinase (RTK) involved in numerous aspects of both normal and pathological angiogenesis. Proper functioning of this receptor is essential for normal development of the vasculature in the embryo as well as vessel maintenance ...
Sturk, Celina Marie
core +2 more sources
Cell Communication and Signaling, 2020 Background Venous malformations (VMs), most of which associated with activating mutations in the endothelial cells (ECs) tyrosine kinase receptor TIE2, are characterized by dilated and immature veins with scarce smooth muscle cells (SMCs) coverage ...
Yameng Si +7 more
doaj +1 more source
Blockade of angiopoietin-2/Tie2 signaling pathway specifically promotes inflammation-induced angiogenesis in mouse cornea [PDF]
International Journal of Ophthalmology, 2017 AIM: To investigate angiopoietin-2 (Ang-2)/Tie2 signaling pathway involving in inflammatory angiogenesis. METHODS: Three interrupted 11-0 nylon sutures were placed into the corneal stroma of BALB/c mice (6wk old) to induce inflammatory ...
Zhi-Xin Yan, Yi Luo, Ning-Fei Liu
doaj +1 more source
Regulation of tie2 expression by angiopoietin--potential feedback system
, 2004 To study a potential feedback system in the angiopoietin (Ang)-Tie2 system, the authors examined effects of Ang1 and Ang2 on Tie2 expression on human umbilical vein endothelial cells (HUVECs) with or without stimulation by a potent inflammatory cytokine,
Wu, Yongqin +5 more
core +1 more source