Results 71 to 80 of about 33,818 (248)
EBioMedicine, 2021 Background Malaria during pregnancy is a major contributor to the global burden of adverse birth outcomes including fetal growth restriction, preterm birth, and fetal loss. Recent evidence supports a role for angiogenic dysregulation and perturbations to
V. Tran +15 more
semanticscholar +1 more source
Cell Reports, 2015 Tie1 is a mechanistically poorly characterized endothelial cell (EC)-specific orphan receptor. Yet, Tie1 deletion is embryonic lethal and Tie1 has been implicated in critical vascular pathologies, including atherosclerosis and tumor angiogenesis.
Soniya Savant +15 more
doaj +1 more source
Phosphorylation of Tie2 Endodomain.
, 2013 A Endothelial cells were incubated for 24 h in the absence of presence of PMA, as indicated, before stimulation with Ang1 for 30 min. Cell lysates were resolved by SDS/PAGE, transferred to nitrocellulose and probed for phospho-Tie2 (pTie2) and Tie2 as ...
Tania M. Hansen (336147) +3 more
core +1 more source
International Journal of Molecular Sciences, 2021 Previous work showed a link between Tie2+ nucleus pulposus progenitor cells (NPPC) and disc degeneration. However, NPPC remain difficult to maintain in culture.
K. Sako +8 more
semanticscholar +1 more source
Advanced Materials, EarlyView.SPARC (spatio‐chimeric, plasma‐based, anisotropic, and shear‐responsive construct) that integrates myogenic and vascular microenvironments within a single construct. The dual‐modulus matrix directs aligned myotube formation and endothelial network development, enabling a vascularized muscle implant that seamlessly anastomoses with host tissue and ...
Su Hyun Jung +6 more
wiley +1 more source
Characterization of Tie2-hsEH mice.
, 2013 A. Schematic of the Tie2-hsEH transgenic construct used to generate mice used in this study. B. Sections of WT (left) and Tie2-hsEH (right) mouse brains immunolabeled for human sEH showing sEH in capillaries and large vessels in Tie2-hsEH. Inserts, blood
Darryl C. Zeldin (16449) +5 more
core +1 more source
Advanced Science, EarlyView.Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia +17 more
wiley +1 more source
Bovine coccygeal intervertebral discs contain multipotent Tie2+ cells which can differentiate into osteogenic and adipogenic lineages [PDF]
, 2015 Question: The intervertebral disc (IVD) has a limited regenerative potential and low back pain represents a leading cause of disability [1]. IVD repair strategies require an appropriate cell source that is able to regenerate the damaged tissue such as ...
Benneker, Lorin M. +8 more
core
Tie2 receptor expression and phosphorylation in cultured cells and mouse tissues
, 1997 Accumulating experimental evidence indicates that endothelial cell growth and blood vessel morphogenesis are processes that are governed by the activity of specifically expressed receptor tyrosine kinases (RTKs).
Thomas I. Koblizek +11 more
core +1 more source
Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]
, 2013 We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Di Qin (107446) +20 more
core +1 more source