Results 51 to 60 of about 33,818 (248)
Angiopoietins and Tie2 in vascular inflammation [PDF]
Current Opinion in Hematology, 2017 Purpose of review As a subset of the organism-wide reaction to severe infection, the host vascular response has received increasing attention in recent years. The transformation that small blood vessels undergo to facilitate the clearance of pathogens may become harmful to the host if it occurs too broadly or if it is sustained
openaire +2 more sources
Science Advances, 2022 Cytokinin plays critical roles in root development. Cytokinin signaling depends on activation of key transcription factors known as type B Arabidopsis response regulators (ARRs).
Qing He +12 more
semanticscholar +1 more source
Sex differences and loss of Tie2
, 2023 The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account.
Brom, Dr.ing. C.E. van den (Amsterdam UMC) ORCID=0000-0002-0886-1388
core +1 more source
Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis
BMC Biology, 2018 Background Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activation of integrins by Tie2 ...
Tomer Shlamkovich +4 more
doaj +1 more source
Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype. [PDF]
PLoS ONE, 2014 Angiopoietin (Ang) -1 and -2 and their receptor Tie2 play critical roles in regulating angiogenic processes during development, homeostasis, tumorigenesis, inflammation and tissue repair.
Samuel García +9 more
doaj +1 more source
Nature Communications, 2021 Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures.
H. Zhou +10 more
semanticscholar +1 more source
EMBO Molecular Medicine, 2021 Anti‐angiogenic drugs targeting the VEGF pathway are most effective in advanced metastatic disease settings of certain types of cancers, whereas they have been unsuccessful as adjuvant therapies of micrometastatic disease in numerous phase III trials ...
Kabir A. Khan +3 more
semanticscholar +1 more source
Polymorphisms in TIE2 and ANGPT-1 genes are associated with protection against diabetic retinopathy in a Brazilian population [PDF]
Archives of Endocrinology and Metabolism, 2023 Objective: The objective of this study was to investigate the association between SNPs in the TIE2 and ANGPT-1 genes and diabetic retinopathy (DR). Subjects and methods: This study comprised 603 patients with type 2 diabetes mellitus (T2DM) and DR ...
Cristine Dieter +8 more
doaj +1 more source
A preliminary study on the pathogenesis of venous malformations caused by Tie2-L914F mutations in endothelial cells [PDF]
Kouqiang yixueObjective To investigate the effects of TEK receptor tyrosine kinase (Tie2) L914F mutation on the biological behavior of vascular endothelial cells and the changes of related signaling pathways in patients with venous malformations.
QI Yuchen, HUANG Jiadong, LI Tianyi, LENG Chunru, SI Yameng
doaj +1 more source
Differential expression of Tie2 receptor and VEGFR2 by endothelial clones derived from isolated bovine mononuclear cells. [PDF]
PLoS ONE, 2012 The purpose of these experiments was to evaluate the expression of endothelial markers, such as Tie2 and VEGFR2 in endothelial cells derived from blood mononuclear endothelial progenitor cells.
Una Adamcic +2 more
doaj +1 more source