Results 31 to 40 of about 33,818 (248)

Angiopoietin/Tie2 signalling and its role in retinal and choroidal vascular diseases: a review of preclinical data

Eye, 2021
The angopoietin/tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (Ang/Tie) pathway is an emerging key regulator in vascular development and maintenance.
A. Joussen, F. Ricci, Liliana P. Paris, C. Korn, Carlos Quezada-Ruiz, M. Zarbin   +5 more
semanticscholar   +1 more source

Flt3- and Tie2-Cre tracing identifies regeneration in sepsis from multipotent progenitors but not hematopoietic stem cells.

Cell Stem Cell, 2023
In response to infections and stress, hematopoiesis rapidly enhances blood and immune cell production. The stage within the hematopoietic hierarchy that accounts for this regeneration is unclear under natural conditions in vivo.
Ann-Kathrin Fanti, Katrin Busch, A. Greco, Xi Wang, B. Cirovic, Fuwei Shang, T. Nizharadze, L. Frank, Melania Barile, T. Feyerabend, T. Höfer, H. Rodewald   +11 more
semanticscholar   +1 more source

Activation of Angiopoietin-Tie2 Signaling Protects the Kidney from Ischemic Injury by Modulation of Endothelial-Specific Pathways

Journal of the American Society of Nephrology, 2023
Significance Statement Ischemia-reperfusion AKI (IR-AKI) is common and causes significant morbidity. Effective treatments are lacking. However, preclinical studies suggest that inhibition of angiopoietin-Tie2 vascular signaling promotes injury, whereas ...
Yanyang Li, Pan Liu, Yalu Zhou, H. Maekawa, John B Silva, M. Ansari, Khaled Boubes, Y. Alia, D. Deb, B. R. Thomson, Jing Jin, S. Quaggin   +11 more
semanticscholar   +1 more source

Macrophage-derived SHP-2 inhibits the metastasis of colorectal cancer via Tie2-PI3K signals

Oncology Research, 2023
This research aimed to explore the influence of Src homology-2 containing protein tyrosine phosphatase (SHP-2) on the functions of tyrosine kinase receptors with immunoglobulin and EGF homology domains 2 (Tie2)-expressing monocyte/macrophages (TEMs) and ...
Xueliang Wu, Shaoyu Guan, Yonggang Lu, J. Xue, Xiangyang Yu, Qi Zhang, Ximo Wang, Tian-Yang Li   +7 more
semanticscholar   +1 more source

Tumor cell-derived exosomes deliver TIE2 protein to macrophages to promote angiogenesis in cervical cancer.

Cancer Letters, 2022
Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2 (TIE2)-expressing macrophages (TEMs) are an angiogenesis-promoting subset of tumor-associated macrophages that have been demonstrated to be increased in solid tumors and ...
Shi Du, Jiaxian Qian, Shuran Tan, Wenhan Li, Pan Liu, Jing Zhao, Ya Zeng, Linjuan Xu, Zehua Wang, Jiong Cai   +9 more
semanticscholar   +1 more source

Pharmacological Tie2 activation in kidney transplantation [PDF]

World Journal of Transplantation, 2016
To investigate the therapeutic potential of vasculotide (VT) - a Tie2 activating therapeutic - in kidney transplantation.We performed a murine MHC-mismatched renal transplant model (C57Bl/6 male into Balb/c female) with 60 min cold and 30 min warm ischemia time. 500 ng VT was administered i.p. to donor mice 1 h before organ removal.
Thamm, Kristina, Njau, Florence, Van Slyke, Paul, Dumont, Daniel J, Park, Joon-Keun, Haller, Hermann, David, Sascha   +6 more
openaire   +2 more sources

Glucagon-like Peptide-1 receptor Tie2+ cells are essential for the cardioprotective actions of liraglutide in mice with experimental myocardial infarction

Molecular Metabolism, 2022
Objectives Glucagon-like peptide-1 receptor (GLP-1R) agonists reduce the rates of major cardiovascular events, including myocardial infarction in people with type 2 diabetes, and decrease infarct size while preserving ventricular function in preclinical ...
Brent A. McLean, C. Wong, M. G. Kabir, D. Drucker   +3 more
semanticscholar   +1 more source

Tek (Tie2) is not required for cardiovascular development in zebrafish [PDF]

Development, 2020
ABSTRACT Angiopoietin/TIE signalling plays a major role in blood and lymphatic vessel development. In mouse, Tek (previously known as Tie2) mutants die prenatally due to a severely underdeveloped cardiovascular system. In contrast, in zebrafish, previous studies have reported that although embryos injected with tek morpholinos (MOs ...
Zhen Jiang, Claudia Carlantoni, Srinivas Allanki, Ingo Ebersberger, Didier Y. R. Stainier   +4 more
openaire   +3 more sources

Type I Interferons induce endothelial destabilization in Systemic Lupus Erythematosus in a Tie2-dependent manner

Frontiers in Immunology, 2023
Endothelial cell (EC) dysfunction is a hallmark of Systemic Lupus Erythematosus (SLE) and Tie2 is a receptor essential for vascular stability. Inflammatory processes promote inhibition of Tie2 homeostatic activation, driving vascular dysfunction. In this
C. Rafael-Vidal, S. Martínez-Ramos, B. Malvar-Fernández, I. Altabás-González, Coral Mouriño, D. Veale, A. Floudas, Ursula Fearon, José María Pego Reigosa, S. García   +9 more
semanticscholar   +1 more source

Targeting the Tie2/Tek Receptor in Astrocytomas [PDF]

The American Journal of Pathology, 2004
Tie2 is an endothelial cell-specific receptor tyrosine kinase, whose activation is positively and negatively modulated by angiopoietin-1 and angiopoietin-2, respectively. Angiopoietin-mediated modulation of Tie2 activation contributes to normal vessel development and stability, however, its role in tumor angiogenesis is not well known.
Gelareh, Zadeh, Baoping, Qian, Ali, Okhowat, Nesrin, Sabha, Christopher D, Kontos, Abhijit, Guha   +5 more
openaire   +2 more sources