Results 31 to 40 of about 30,973 (211)
A preliminary study on the pathogenesis of venous malformations caused by Tie2-L914F mutations in endothelial cells [PDF]
Kouqiang yixueObjective To investigate the effects of TEK receptor tyrosine kinase (Tie2) L914F mutation on the biological behavior of vascular endothelial cells and the changes of related signaling pathways in patients with venous malformations.
QI Yuchen, HUANG Jiadong, LI Tianyi, LENG Chunru, SI Yameng
doaj +1 more source
Pharmacological Tie2 activation in kidney transplantation [PDF]
World Journal of Transplantation, 2016 To investigate the therapeutic potential of vasculotide (VT) - a Tie2 activating therapeutic - in kidney transplantation.We performed a murine MHC-mismatched renal transplant model (C57Bl/6 male into Balb/c female) with 60 min cold and 30 min warm ischemia time. 500 ng VT was administered i.p. to donor mice 1 h before organ removal.
Thamm, Kristina +6 more
openaire +2 more sources
Differential expression of Tie2 receptor and VEGFR2 by endothelial clones derived from isolated bovine mononuclear cells. [PDF]
PLoS ONE, 2012 The purpose of these experiments was to evaluate the expression of endothelial markers, such as Tie2 and VEGFR2 in endothelial cells derived from blood mononuclear endothelial progenitor cells.
Una Adamcic +2 more
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Polymorphisms in TIE2 and ANGPT-1 genes are associated with protection against diabetic retinopathy in a Brazilian population [PDF]
Archives of Endocrinology and Metabolism, 2023 Objective: The objective of this study was to investigate the association between SNPs in the TIE2 and ANGPT-1 genes and diabetic retinopathy (DR). Subjects and methods: This study comprised 603 patients with type 2 diabetes mellitus (T2DM) and DR ...
Cristine Dieter +8 more
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Characterization of Tie2 signalling during acute inflammation [PDF]
, 2018 The inflammatory response is essential for the eradication of lipopolysaccharide (LPS) presenting microbial invaders. However, resolution is also important to prevent detrimental vascular inflammation to the host.
Smith, Tracy Lauren
core +2 more sources
The Tie2 signaling pathway in retinal vascular diseases: a novel therapeutic target in the eye
International Journal of Retina and Vitreous, 2020 Background Retinal vascular diseases such as neovascular age-related macular degeneration, diabetic retinopathy and/or diabetic macular edema, and retinal vein occlusion with macular edema—share several key pathophysiologic aspects including ...
Quan Dong Nguyen +6 more
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Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo
Intensive Care Medicine Experimental, 2021 Background Reduced endothelial Tie2 expression occurs in diverse experimental models of critical illness, and experimental Tie2 suppression is sufficient to increase spontaneous vascular permeability.
Temitayo O. Idowu +6 more
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Targeting the Tie2/Tek Receptor in Astrocytomas [PDF]
The American Journal of Pathology, 2004 Tie2 is an endothelial cell-specific receptor tyrosine kinase, whose activation is positively and negatively modulated by angiopoietin-1 and angiopoietin-2, respectively. Angiopoietin-mediated modulation of Tie2 activation contributes to normal vessel development and stability, however, its role in tumor angiogenesis is not well known.
Gelareh, Zadeh +5 more
openaire +2 more sources
The Angiopoietin-Tie2 Pathway in Critical Illness
Critical Care Clinics, 2020 Lethal features of sepsis and acute respiratory distress syndrome (ARDS) relate to the health of small blood vessels. For example, alveolar infiltration with proteinaceous fluid is often driven by breach of the microvascular barrier. Spontaneous thrombus formation within inflamed microvessels exacerbates organ ischemia, and in its final stages, erupts ...
Kelsey D, Sack +2 more
openaire +3 more sources
Global Spine Journal, 2015 Introduction The intervertebral disc (IVD) has a limited regenerative potential and low back pain represents a leading cause of disability. 1 IVD repair strategies require an appropriate cell source that is able to regenerate the damaged tissue such as ...
Adel Tekari +6 more
doaj +1 more source