Results 31 to 40 of about 27,290 (180)

Polymorphisms in TIE2 and ANGPT-1 genes are associated with protection against diabetic retinopathy in a Brazilian population [PDF]

Archives of Endocrinology and Metabolism, 2023
Objective: The objective of this study was to investigate the association between SNPs in the TIE2 and ANGPT-1 genes and diabetic retinopathy (DR). Subjects and methods: This study comprised 603 patients with type 2 diabetes mellitus (T2DM) and DR ...
Cristine Dieter, Natália Emerim Lemos, Nathalia Rodrigues de Faria Corrêa, Taís Silveira Assmann, Felipe Mateus Pellenz, Luís Henrique Canani, Letícia de Almeida Brondani, Andrea Carla Bauer, Daisy Crispim   +8 more
doaj   +1 more source

The Tie2 signaling pathway in retinal vascular diseases: a novel therapeutic target in the eye

International Journal of Retina and Vitreous, 2020
Background Retinal vascular diseases such as neovascular age-related macular degeneration, diabetic retinopathy and/or diabetic macular edema, and retinal vein occlusion with macular edema—share several key pathophysiologic aspects including ...
Quan Dong Nguyen, Jeffrey S. Heier, Diana V. Do, Adam C. Mirando, Niranjan B. Pandey, Huan Sheng, Theresa Heah   +6 more
doaj   +1 more source

Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo

Intensive Care Medicine Experimental, 2021
Background Reduced endothelial Tie2 expression occurs in diverse experimental models of critical illness, and experimental Tie2 suppression is sufficient to increase spontaneous vascular permeability.
Temitayo O. Idowu, Valerie Etzrodt, Thorben Pape, Joerg Heineke, Klaus Stahl, Hermann Haller, Sascha David   +6 more
doaj   +1 more source

Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells

Stem Cell Research & Therapy, 2016
Background The intervertebral disc (IVD) has limited self-healing potential and disc repair strategies require an appropriate cell source such as progenitor cells that could regenerate the damaged cells and tissues.
Adel Tekari, Samantha C. W. Chan, Daisuke Sakai, Sibylle Grad, Benjamin Gantenbein   +4 more
doaj   +1 more source

Tie2+ Cells of the Bovine Nucleus Pulposus are Progenitor Cells Capable of Differentiating into Osteocytes and Adipocytes

Global Spine Journal, 2015
Introduction The intervertebral disc (IVD) has a limited regenerative potential and low back pain represents a leading cause of disability. 1 IVD repair strategies require an appropriate cell source that is able to regenerate the damaged tissue such as ...
Adel Tekari, Samantha Chan, Karin Wuertz, Daisuke Sakai, Lorin M. Benneker, Sibylle Grad, Benjamin Gantenbein   +6 more
doaj   +1 more source

The Angiopoietin-Tie2 Pathway in Critical Illness

Critical Care Clinics, 2020
Lethal features of sepsis and acute respiratory distress syndrome (ARDS) relate to the health of small blood vessels. For example, alveolar infiltration with proteinaceous fluid is often driven by breach of the microvascular barrier. Spontaneous thrombus formation within inflamed microvessels exacerbates organ ischemia, and in its final stages, erupts ...
Kelsey D, Sack, John A, Kellum, Samir M, Parikh   +2 more
openaire   +3 more sources

Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

eLife, 2016
Mechanisms underlying the vein development remain largely unknown. Tie2 signaling mediates endothelial cell (EC) survival and vascular maturation and its activating mutations are linked to venous malformations.
Man Chu, Taotao Li, Bin Shen, Xudong Cao, Haoyu Zhong, Luqing Zhang, Fei Zhou, Wenjuan Ma, Haijuan Jiang, Pancheng Xie, Zhengzheng Liu, Ningzheng Dong, Ying Xu, Yun Zhao, Guoqiang Xu, Peirong Lu, Jincai Luo, Qingyu Wu, Kari Alitalo, Gou Young Koh, Ralf H Adams, Yulong He   +21 more
doaj   +1 more source

Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression. [PDF]

PLoS ONE, 2013
Tight regulation of vascular permeability is necessary for normal development and deregulated vascular barrier function contributes to the pathogenesis of various diseases, including acute respiratory distress syndrome, cancer and inflammation.
Tadanori Mammoto, Elisabeth Jiang, Amanda Jiang, Yongbo Lu, Aimee M Juan, Jing Chen, Akiko Mammoto   +6 more
doaj   +1 more source

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species

JOR Spine, 2018
Background Recently, Tie2/TEK receptor tyrosine kinase (Tie2 or syn. angiopoietin‐1 receptor) positive nucleus pulposus progenitor cells were detected in human, cattle, and mouse.
Daisuke Sakai, Jordy Schol, Frances C. Bach, Adel Tekari, Nobuho Sagawa, Yoshihiko Nakamura, Samantha C.W. Chan, Tomoko Nakai, Laura B. Creemers, Daniela A. Frauchiger, Rahel D. May, Sibylle Grad, Masahiko Watanabe, Marianna A. Tryfonidou, Benjamin Gantenbein   +14 more
doaj   +1 more source

Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice

Biomedicines, 2023
In Duchenne muscular dystrophy (DMD), angiogenesis appears to be attenuated. Local administration of angiopoietin 1 (Ang1) has been shown to reduce inflammation, ischemia, and fibrosis in DMD mice.
Yiming Lin, Andrew McClennan, Lisa Hoffman   +2 more
doaj   +1 more source