Results 11 to 20 of about 27,290 (180)
Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody [PDF]
Nature Communications, 2021 Angiopoietin (Angpt)-Tie receptor 2 (Tie2) regulates vascular stability and is thus a potential therapeutic target in vascular diseases. Here, the authors report a Tie2-agonistic antibody which targets a site distinct from the Angpt 1-binding site and ...
Gyunghee Jo +9 more
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Efficacy of Tie2 Receptor Antagonism in Angiosarcoma
Neoplasia: An International Journal for Oncology Research, 2012 Angiosarcomas are malignant endothelial cell tumors with few effective systemic treatments. Despite a unique endothelial origin, molecular candidates for targeted therapeutic intervention have been elusive.
Jason R. Hasenstein +6 more
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Angpt2/Tie2 autostimulatory loop controls tumorigenesis
EMBO Molecular Medicine, 2022 Invasive nonfunctioning (NF) pituitary neuroendocrine tumors (PitNETs) are non‐resectable neoplasms associated with frequent relapses and significant comorbidities.
Ninelia Minaskan Karabid +20 more
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Tyrosine phosphorylation of Grb14 by Tie2 [PDF]
Cell Communication and Signaling, 2010 Background Growth factor receptor bound (Grb) proteins 7, 10 and 14 are a family of structurally related multi-domain adaptor proteins involved in a variety of biological processes.
Dumont Daniel J, Sturk Celina
doaj +4 more sources
Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Tie1 and Tie2 receptor tyrosine kinases are key regulators of blood and lymphatic vessel development and of pathological processes including tumor angiogenesis, atherosclerosis, and vascular leakage, e.g., in sepsis.
Alitalo Kari +5 more
openaire +3 more sources
The Angiopoietin/Tie2 Pathway in Hepatocellular Carcinoma [PDF]
Cells, 2020 Due to the usually late diagnosis and lack of effective therapies, hepatocellular carcinoma (HCC), which poses a growing global health problem, is characterized by a poor prognosis. Angiogenesis plays an important role in HCC progression, and vascular endothelial growth factor (VEGF) and angiopoietins (Angs) are key drivers of HCC angiogenesis.
Bart Vanderborght +3 more
openaire +4 more sources
Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis
eLife, 2020 Endothelial Tie2 signaling plays a pivotal role in vascular barrier maintenance at baseline and after injury. We previously demonstrated that a sharp drop in Tie2 expression observed across various murine models of critical illnesses is associated with ...
Temitayo O Idowu +6 more
doaj +1 more source
Клиническая онкогематология, 2014 This review focuses on association between the selectivity of Bcr-Abl kinase inhibitors and the spectrum of their adverse effects during treatment of patients with chronic myeloid leukemia.
A. A. Zeifman +3 more
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The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling. [PDF]
PLoS ONE, 2012 Angiopoietin-1 (Ang1) signals via the receptor tyrosine kinase Tie2 which exists in complex with the related protein Tie1 at the endothelial cell surface.
Harprit Singh +3 more
doaj +1 more source
Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism
Biology Open, 2014 In this study, we have identified a novel member of the AMPK family, namely Sucrose non-fermenting related kinase (Snrk), that is responsible for maintaining cardiac metabolism in mammals. SNRK is expressed in the heart, and brain, and in cell types such
Stephanie M. Cossette +16 more
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