Results 11 to 20 of about 33,818 (248)

Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody [PDF]

Nature Communications, 2021
Angiopoietin (Angpt)-Tie receptor 2 (Tie2) regulates vascular stability and is thus a potential therapeutic target in vascular diseases. Here, the authors report a Tie2-agonistic antibody which targets a site distinct from the Angpt 1-binding site and ...
Gyunghee Jo, Jeomil Bae, Ho Jeong Hong, Ah-reum Han, Do-Kyun Kim, Seon Pyo Hong, Jung A Kim, Sangkyu Lee, Gou Young Koh, Ho Min Kim   +9 more
doaj   +5 more sources

Angpt2/Tie2 autostimulatory loop controls tumorigenesis [PDF]

EMBO Molecular Medicine, 2022
Invasive nonfunctioning (NF) pituitary neuroendocrine tumors (PitNETs) are non‐resectable neoplasms associated with frequent relapses and significant comorbidities.
Ninelia Minaskan Karabid, Tobias Wiedemann, Sebastian Gulde, Hermine Mohr, Renu Chandra Segaran, Julia Geppert, Maria Rohm, Giovanni Vitale, Germano Gaudenzi, Alessandra Dicitore, Donna Pauler Ankerst, Yiyao Chen, Rickmer Braren, Georg Kaissis, Franz Schilling, Mathias Schillmaier, Graeme Eisenhofer, Stephan Herzig, Federico Roncaroli, Jürgen B Honegger, Natalia S Pellegata   +20 more
doaj   +9 more sources

Efficacy of Tie2 Receptor Antagonism in Angiosarcoma

Neoplasia: An International Journal for Oncology Research, 2012
Angiosarcomas are malignant endothelial cell tumors with few effective systemic treatments. Despite a unique endothelial origin, molecular candidates for targeted therapeutic intervention have been elusive.
Jason R. Hasenstein, Kelsey Kasmerchak, Darya Buehler, Gholam Reza Hafez, Kevin Cleary, John S. Moody, Kevin R. Kozak   +6 more
doaj   +4 more sources

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium

Nature Cardiovascular Research, 2023
AbstractLeukocytes and resident cells in the arterial wall contribute to atherosclerosis, especially at sites of disturbed blood flow. Expression of endothelial Tie1 receptor tyrosine kinase is enhanced at these sites, and attenuation of its expression reduces atherosclerotic burden and decreases inflammation.
Andrey Anisimov, Shentong Fang, Karthik Amudhala Hemanthakumar, Tiit Örd, Kristof van Avondt, Raphael Chevre, Anu Toropainen, Prosanta Singha, Huda Gilani, Su D. Nguyen, Sinem Karaman, Emilia A. Korhonen, Ralf H. Adams, Hellmut G. Augustin, Katariina Öörni, Oliver Soehnlein, Minna U. Kaikkonen, Kari Alitalo   +17 more
core   +5 more sources

Tyrosine phosphorylation of Grb14 by Tie2 [PDF]

Cell Communication and Signaling, 2010
Background Growth factor receptor bound (Grb) proteins 7, 10 and 14 are a family of structurally related multi-domain adaptor proteins involved in a variety of biological processes.
Dumont Daniel J, Sturk Celina
doaj   +6 more sources

Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Tie1 and Tie2 receptor tyrosine kinases are key regulators of blood and lymphatic vessel development and of pathological processes including tumor angiogenesis, atherosclerosis, and vascular leakage, e.g., in sepsis. Tie1 is essential for the Tie2 agonist activity of angiopoietins, and the activated receptors form heteromeric ...
Alitalo Kari, Saharinen Pipsa, Leppanen Veli-Matti, Alitalo Kari, Saharinen Pipsa, Leppanen Veli-Matti   +5 more
openaire   +4 more sources

The Angiopoietin/Tie2 Pathway in Hepatocellular Carcinoma [PDF]

Cells, 2020
Due to the usually late diagnosis and lack of effective therapies, hepatocellular carcinoma (HCC), which poses a growing global health problem, is characterized by a poor prognosis. Angiogenesis plays an important role in HCC progression, and vascular endothelial growth factor (VEGF) and angiopoietins (Angs) are key drivers of HCC angiogenesis.
Bart Vanderborght, Sander Lefere, Hans Van Vlierberghe, Lindsey Devisscher   +3 more
openaire   +5 more sources

The Angiopoietin-Tie2 Pathway in Critical Illness

Critical Care Clinics, 2020
Lethal features of sepsis and acute respiratory distress syndrome (ARDS) relate to the health of small blood vessels. For example, alveolar infiltration with proteinaceous fluid is often driven by breach of the microvascular barrier. Spontaneous thrombus formation within inflamed microvessels exacerbates organ ischemia, and in its final stages, erupts ...
Kelsey D, Sack, John A, Kellum, Samir M, Parikh   +2 more
openaire   +4 more sources

Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells [PDF]

Stem Cell Research & Therapy, 2016
Background The intervertebral disc (IVD) has limited self-healing potential and disc repair strategies require an appropriate cell source such as progenitor cells that could regenerate the damaged cells and tissues.
Adel Tekari, Samantha C. W. Chan, Daisuke Sakai, Sibylle Grad, Benjamin Gantenbein   +4 more
doaj   +2 more sources

Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration

EMBO Molecular Medicine, 2023
Vascular endothelial protein tyrosine phosphatase (VE‐PTP) influences endothelial barrier function by regulating the activation of tyrosine kinase receptor Tie2.
Keisuke Shirakura, Peter Baluk, Astrid F Nottebaum, Ute Ipe, Kevin G Peters, Donald M McDonald, Dietmar Vestweber   +6 more
doaj   +2 more sources