Results 11 to 20 of about 30,973 (211)
Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody [PDF]
Nature Communications, 2021 Angiopoietin (Angpt)-Tie receptor 2 (Tie2) regulates vascular stability and is thus a potential therapeutic target in vascular diseases. Here, the authors report a Tie2-agonistic antibody which targets a site distinct from the Angpt 1-binding site and ...
Gyunghee Jo +9 more
doaj +4 more sources
Efficacy of Tie2 Receptor Antagonism in Angiosarcoma [PDF]
Neoplasia: An International Journal for Oncology Research, 2012 Angiosarcomas are malignant endothelial cell tumors with few effective systemic treatments. Despite a unique endothelial origin, molecular candidates for targeted therapeutic intervention have been elusive.
Jason R. Hasenstein +6 more
doaj +4 more sources
Angpt2/Tie2 autostimulatory loop controls tumorigenesis [PDF]
EMBO Molecular Medicine, 2022 Invasive nonfunctioning (NF) pituitary neuroendocrine tumors (PitNETs) are non‐resectable neoplasms associated with frequent relapses and significant comorbidities.
Ninelia Minaskan Karabid +20 more
doaj +9 more sources
Tyrosine phosphorylation of Grb14 by Tie2 [PDF]
Cell Communication and Signaling, 2010 Background Growth factor receptor bound (Grb) proteins 7, 10 and 14 are a family of structurally related multi-domain adaptor proteins involved in a variety of biological processes.
Dumont Daniel J, Sturk Celina
doaj +6 more sources
Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Tie1 and Tie2 receptor tyrosine kinases are key regulators of blood and lymphatic vessel development and of pathological processes including tumor angiogenesis, atherosclerosis, and vascular leakage, e.g., in sepsis.
Alitalo Kari +5 more
openaire +4 more sources
Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells [PDF]
Stem Cell Research & Therapy, 2016 Background The intervertebral disc (IVD) has limited self-healing potential and disc repair strategies require an appropriate cell source such as progenitor cells that could regenerate the damaged cells and tissues.
Adel Tekari +4 more
doaj +3 more sources
Molecular Regulation of Acute Tie2 Suppression in Sepsis [PDF]
Critical Care Medicine, 2018 Objectives: Tie2 is a tyrosine kinase receptor expressed by endothelial cells that maintains vascular barrier function. We recently reported that diverse critical illnesses acutely decrease Tie2 expression and that experimental Tie2 reduction suffices to recapitulate cardinal features of the septic vasculature.
Thamm, Kristina +11 more
openaire +4 more sources
The flow dependency of Tie2 expression in endotoxemia
Intensive Care Medicine, 2013 Tie2 is predominantly expressed by endothelial cells and is involved in vascular integrity control during sepsis. Changes in Tie2 expression during sepsis development may contribute to microvascular dysfunction. Understanding the kinetics and molecular basis of these changes may assist in the development of therapeutic intervention to counteract ...
Kurniati, Neng F. +15 more
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Increased Expression of Angiopoietin 2 and Tie2 in Rosacea
DermatopathologyIn this study we evaluated the expression of Angiopoietin 1, Angiopoietin 2, and Tie2 by immunohistochemistry in the skin of 10 patients with erythemato telangiectatic and papulopustular rosacea.
Aysin Kaya +3 more
doaj +4 more sources
The Angiopoietin/Tie2 Pathway in Hepatocellular Carcinoma [PDF]
Cells, 2020 Due to the usually late diagnosis and lack of effective therapies, hepatocellular carcinoma (HCC), which poses a growing global health problem, is characterized by a poor prognosis. Angiogenesis plays an important role in HCC progression, and vascular endothelial growth factor (VEGF) and angiopoietins (Angs) are key drivers of HCC angiogenesis.
Bart Vanderborght +3 more
openaire +4 more sources