Results 1 to 10 of about 33,818 (248)

TIE2-high cervical cancer cells promote tumor angiogenesis by upregulating TIE2 and VEGFR2 in endothelial cells

Translational Oncology, 2022
Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2 (TIE2), the receptor for angiopoietins, has been found highly expressed in cervical cancer and associated with poor prognosis.
Wenhan Li, Pan Liu, Jing Cai
exaly   +6 more sources

Increased Expression of Angiopoietin 2 and Tie2 in Rosacea [PDF]

Dermatopathology
In this study we evaluated the expression of Angiopoietin 1, Angiopoietin 2, and Tie2 by immunohistochemistry in the skin of 10 patients with erythemato telangiectatic and papulopustular rosacea.
Aysin Kaya, Jean-Hilaire Saurat, Nathalie Satta, Gürkan Kaya   +3 more
doaj   +5 more sources

Tie2 inhibition disrupts TMEM doorway function and reduces dissemination in pancreatic ductal adenocarcinoma [PDF]

Journal of Experimental & Clinical Cancer Research
Background Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic malignancy with limited treatment options. Metastatic dissemination is the principal cause of mortality in PDAC, yet the cellular mechanism by which PDAC tumor cells enter the ...
Erika Pereira Zambalde, Lina A. Ariyan, Francisco Puerta-Martinez, Yu Qin Zhu, Priyanka Patil, Nicole C. Panarelli, Jiufeng Li, Yookyung Jung, Christian Adkisson, Jakeb Petersen, Dianne Cox, Hava Gil-Henn, Robert Eddy, Ben Z. Stanger, David Entenberg, Maja H. Oktay, John S. Condeelis, John C. McAuliffe   +17 more
doaj   +2 more sources

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling. [PDF]

Dev Dyn
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Bischoff LJ, Schrenk S, Soroko K, Sherpa C, Arasu A, Reynaud D, Boscolo E.   +6 more
europepmc   +2 more sources

Prophylactic Nebulized hUC-MSC-EVs Attenuate Hypobaric Hypoxia-Induced Lung Injury via Alveolar–Capillary Barrier Stabilization and TEK/Tie2 Preservation [PDF]

Biomedicines
Background/Objectives: High-altitude pulmonary edema (HAPE) remains a serious condition with limited preventive options. This study evaluated the prophylactic protective effects of nebulized human umbilical cord mesenchymal stem cell-derived ...
Peixin Wu, Yue Yin, Jinxia Liu, Zhenfei Mo, Jiabo Ren, Xiuqing Ma, Zhixin Liang, Miaoyu Wang, Chunsun Li, Liangan Chen   +9 more
doaj   +2 more sources

CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity [PDF]

iScience
Summary: The Ets transcription factors induce the expression of Tie2 and VE-cadherin. However, the regulation of these factors remains unknown. Here, we found that the gene encoding the Ets factor Elf2 was hypermethylated in Camkkβ-deficient (Camkkβ ...
Dong-Mei Wang, Juan Yang, Mohammad Owais Ansari, Zarema Arbieva, Mark Maienschein-Cline, Viswanathan Natarajan, Asrar B. Malik, Chinnaswamy Tiruppathi   +7 more
doaj   +2 more sources

Pattern of tamoxifen-induced Tie2 deletion in endothelial cells in mature blood vessels using endo SCL-Cre-ERT transgenic mice

PLoS ONE, 2022
Tyrosine-protein kinase receptor Tie2, also known as Tunica interna Endothelial cell Kinase or TEK plays a prominent role in endothelial responses to angiogenic and inflammatory stimuli.
Peter J. Zwiers, Rianne M. Jongman, Timara Kuiper, Jill Moser, Radu V. Stan, Joachim R. Göthert, Matijs van Meurs, Eliane R. Popa, Grietje Molema   +8 more
doaj   +3 more sources

Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex.

PLoS ONE, 2023
BackgroundThe endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males.
Anoek L I van Leeuwen, Elise Beijer, Roselique Ibelings, Nicole A M Dekker, Marjolein R A van der Steen, Joris J T H Roelofs, Matijs van Meurs, Grietje Molema, Charissa E van den Brom   +8 more
doaj   +1 more source

Reduced Tie2 in Microvascular Endothelial Cells Is Associated with Organ-Specific Adhesion Molecule Expression in Murine Health and Endotoxemia

Cells, 2023
Endothelial cells (ECs) in the microvasculature in organs are active participants in the pathophysiology of sepsis. Tyrosine protein kinase receptor Tie2 (Tek; Tunica interna Endothelial cell Kinase) is thought to play a role in their inflammatory ...
Peter J. Zwiers, Jacqueline P. F. E. Lucas, Rianne M. Jongman, Matijs van Meurs, Eliane R. Popa, Grietje Molema   +5 more
doaj   +1 more source

Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis

eLife, 2020
Endothelial Tie2 signaling plays a pivotal role in vascular barrier maintenance at baseline and after injury. We previously demonstrated that a sharp drop in Tie2 expression observed across various murine models of critical illnesses is associated with ...
Temitayo O Idowu, Valerie Etzrodt, Benjamin Seeliger, Patricia Bolanos-Palmieri, Kristina Thamm, Hermann Haller, Sascha David   +6 more
doaj   +1 more source