Results 1 to 10 of about 30,973 (211)

TIE2-high cervical cancer cells promote tumor angiogenesis by upregulating TIE2 and VEGFR2 in endothelial cells

Translational Oncology, 2022
Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2 (TIE2), the receptor for angiopoietins, has been found highly expressed in cervical cancer and associated with poor prognosis.
Zehua Wang, Shi Du
exaly   +5 more sources

Inhibition of VEGF-Induced Angiogenesis and Vascular Leakage by Bicistronic Co-Expression of Aflibercept and COMP-Ang1. [PDF]

Adv Healthc Mater
A bicistronic rAAV8 vector encoding Aflibercept (Afb) and COMP‐cAng1 simultaneously coordinates VEGF clearance and Tie2‐mediated vessel maturation. In a 3D angiogenesis‐on‐a‐chip model, rAAV8‐Afb/cAng1 effectively reverses pathological barrier breakdown under clinical disease‐mimicking challenges.
Kim BK, Min J, Park SH, Shin S, Yu S, Park JE, Kim S, Park W, Ko J, Kwon S.   +9 more
europepmc   +2 more sources

Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling [PDF]

The Journal of Clinical Investigation
The blood and lymphatic vascular systems are regulated by angiopoietin (ANGPT) growth factors, which signal via endothelial TIE receptor tyrosine kinases and integrins. However, mechanistic understanding of how these receptors crosstalk is limited. Here,
Tuomas Sipilä, Srinivas Kumar Ponna, Abhinandan Venkatesha Murthy, Anne Pink, Giray Enkavi, Shraman Kumar Bohra, Klaudia Lewna, Keerthana Ganesh, Qina Liu, Mirka Korhonen, Tommi Kajander, Michael Potente, Johanna Ivaska, Ilpo Vattulainen, Veli-Matti Leppänen, Pipsa Saharinen   +15 more
doaj   +2 more sources

A novel Tie2xVEGF bispecific antibody fusion demonstrates enhanced therapeutic efficacy through direct Tie2 activation and VEGF neutralization [PDF]

Journal of Translational Medicine
Background Activation of endothelial Tie2 signaling has emerged as a potential therapeutic strategy for ameliorating vascular abnormalities and hyperpermeability in ocular diseases.
Min-Gi Kwon, Soo Jin Kim, Kangmin Lee, Jin-Hoi Song, Jaemin Lee, Injune Kim, Jeong-Ki Min, Young-Guen Kwon, Dong Gwang Lee, Junyeop Lee, Nam-Kyung Lee   +10 more
doaj   +2 more sources

Tie2 inhibition disrupts TMEM doorway function and reduces dissemination in pancreatic ductal adenocarcinoma [PDF]

Journal of Experimental & Clinical Cancer Research
Background Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic malignancy with limited treatment options. Metastatic dissemination is the principal cause of mortality in PDAC, yet the cellular mechanism by which PDAC tumor cells enter the ...
Erika Pereira Zambalde, Lina A. Ariyan, Francisco Puerta-Martinez, Yu Qin Zhu, Priyanka Patil, Nicole C. Panarelli, Jiufeng Li, Yookyung Jung, Christian Adkisson, Jakeb Petersen, Dianne Cox, Hava Gil-Henn, Robert Eddy, Ben Z. Stanger, David Entenberg, Maja H. Oktay, John S. Condeelis, John C. McAuliffe   +17 more
doaj   +2 more sources

Pattern of tamoxifen-induced Tie2 deletion in endothelial cells in mature blood vessels using endo SCL-Cre-ERT transgenic mice

PLoS ONE, 2022
Tyrosine-protein kinase receptor Tie2, also known as Tunica interna Endothelial cell Kinase or TEK plays a prominent role in endothelial responses to angiogenic and inflammatory stimuli.
Peter J. Zwiers, Rianne M. Jongman, Timara Kuiper, Jill Moser, Radu V. Stan, Joachim R. Göthert, Matijs van Meurs, Eliane R. Popa, Grietje Molema   +8 more
doaj   +3 more sources

Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex.

PLoS ONE, 2023
BackgroundThe endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males.
Anoek L I van Leeuwen, Elise Beijer, Roselique Ibelings, Nicole A M Dekker, Marjolein R A van der Steen, Joris J T H Roelofs, Matijs van Meurs, Grietje Molema, Charissa E van den Brom   +8 more
doaj   +1 more source

Reduced Tie2 in Microvascular Endothelial Cells Is Associated with Organ-Specific Adhesion Molecule Expression in Murine Health and Endotoxemia

Cells, 2023
Endothelial cells (ECs) in the microvasculature in organs are active participants in the pathophysiology of sepsis. Tyrosine protein kinase receptor Tie2 (Tek; Tunica interna Endothelial cell Kinase) is thought to play a role in their inflammatory ...
Peter J. Zwiers, Jacqueline P. F. E. Lucas, Rianne M. Jongman, Matijs van Meurs, Eliane R. Popa, Grietje Molema   +5 more
doaj   +1 more source

Periodontal diseases and adverse pregnancy outcomes. Present and future

Periodontology 2000, EarlyView., 2023
Abstract For more than two decades the possible association between periodontal diseases and adverse pregnancy outcomes has been extensively evaluated. Numerous observational, intervention, and mechanistic studies have offered valuable information on this topic.
Yiorgos A. Bobetsis, Mark Ide, Mervi Gürsoy, Phoebus N. Madianos   +3 more
wiley   +1 more source

Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis

eLife, 2020
Endothelial Tie2 signaling plays a pivotal role in vascular barrier maintenance at baseline and after injury. We previously demonstrated that a sharp drop in Tie2 expression observed across various murine models of critical illnesses is associated with ...
Temitayo O Idowu, Valerie Etzrodt, Benjamin Seeliger, Patricia Bolanos-Palmieri, Kristina Thamm, Hermann Haller, Sascha David   +6 more
doaj   +1 more source