Results 21 to 30 of about 33,818 (248)

Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice

Biomedicines, 2023
In Duchenne muscular dystrophy (DMD), angiogenesis appears to be attenuated. Local administration of angiopoietin 1 (Ang1) has been shown to reduce inflammation, ischemia, and fibrosis in DMD mice.
Yiming Lin, Andrew McClennan, Lisa Hoffman   +2 more
doaj   +2 more sources

The Tie2 signaling pathway in retinal vascular diseases: a novel therapeutic target in the eye

International Journal of Retina and Vitreous, 2020
Background Retinal vascular diseases such as neovascular age-related macular degeneration, diabetic retinopathy and/or diabetic macular edema, and retinal vein occlusion with macular edema—share several key pathophysiologic aspects including ...
Quan Dong Nguyen, Jeffrey S. Heier, Diana V. Do, Adam C. Mirando, Niranjan B. Pandey, Huan Sheng, Theresa Heah   +6 more
doaj   +2 more sources

Molecular Regulation of Acute Tie2 Suppression in Sepsis [PDF]

Critical Care Medicine, 2018
Objectives: Tie2 is a tyrosine kinase receptor expressed by endothelial cells that maintains vascular barrier function. We recently reported that diverse critical illnesses acutely decrease Tie2 expression and that experimental Tie2 reduction suffices to recapitulate cardinal features of the septic vasculature.
Thamm, Kristina, Schrimpf, Claudia, Retzlaff, Jennifer, Idowu, Temitayo O., van Meurs, Matijs, Zijlstra, Jan G., Ghosh, Chandra C., Zeitvogel, Jana, Werfel, Thomas A., Haller, Hermann, Parikh, Samir M., David, Sascha   +11 more
openaire   +4 more sources

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations [PDF]

Nature Cardiovascular Research
Venous malformations (VMs) are vascular anomalies lacking curative treatments, often caused by somatic PIK3CA mutations that hyperactivate the PI3Kα-AKT-mTOR signaling pathway.
Boon, L.M., Vikkula, Miikka, De Roo, A.K., Grosso, A.R., De Roo, An Katrien, Schoofs, Hans, De Roo, An-Katrien, Hägerling, R., Vikkula, M., Petkova, Milena, Andrade, J., Kraft, Marle, Mäkinen, T., Boon, Laurence M., Hägerling, René, Andrade, Jorge, Kapp, Friedrich G., Potente, M., Makinen, Taija, Kraft, M., Petkova, M., Kapp, F.G., Grosso, Ana Rita, Benedito, Rui, Benedito, R., Potente, Michael, Schoofs, H.   +26 more
core   +2 more sources

Pericyte-expressed Tie2 controls angiogenesis and vessel maturation

Nature Communications, 2017
The Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed endothelial-specific expression. Yet, Tie2 is also expressed at lower levels by pericytes and it has
Arne Bartol, Katharina Schlereth, Stella Hertel, Zulfiyya Hasanov, Soniya Savant, Kshitij Srivastava, Laura Milde, Tina Ruckdeschel, Nicolas Gengenbacher, Hellmut G. Augustin, Annegret Holm, Junhao Hu, Martin Teichert, Laura Stanicek   +13 more
core   +2 more sources

Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo [PDF]

Intensive Care Medicine Experimental, 2021
Background Reduced endothelial Tie2 expression occurs in diverse experimental models of critical illness, and experimental Tie2 suppression is sufficient to increase spontaneous vascular permeability.
Temitayo O. Idowu, Valerie Etzrodt, Thorben Pape, Joerg Heineke, Klaus Stahl, Hermann Haller, Sascha David   +6 more
doaj   +2 more sources

Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19

JCI Insight, 2021
Endothelial dysfunction accompanies the microvascular thrombosis commonly observed in severe COVID-19. Constitutively, the endothelial surface is anticoagulant, a property maintained at least in part via signaling through the Tie2 receptor.
Alec A. Schmaier, Gabriel M. Pajares Hurtado, Zachary J. Manickas-Hill, Kelsey D. Sack, Siyu M. Chen, Victoria Bhambhani, Juweria Quadir, Anjali K. Nath, Ai-ris Y. Collier, Debby Ngo, Dan H. Barouch, Nathan I. Shapiro, Robert E. Gerszten, Xu G. Yu, MGH COVID-19 Collection and Processing Team, Kevin G. Peters, Robert Flaumenhaft, Samir M. Parikh   +17 more
doaj   +3 more sources

Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages

Cell Death and Disease, 2021
Bone morphogenetic protein (Bmp) signaling is critical for organismal development and homeostasis. To elucidate Bmp2 function in the vascular/hematopoietic lineages we generated a new transgenic mouse line in which ectopic Bmp2 expression is controlled ...
Belén Prados, Raquel del Toro, Donal MacGrogan, Paula Gómez-Apiñániz, Tania Papoutsi, Pura Muñoz-Cánoves, Simón Méndez-Ferrer, José Luis de la Pompa   +7 more
doaj   +2 more sources

Tie2: a journey from normal angiogenesis to cancer and beyond. [PDF]

Histology and histopathology, 2008
The tyrosine kinase receptor Tie2 was initially identified as a specific vascular growth factor that governed several properties of endothelial cells under both physiological and pathological conditions. It was subsequently found that angiopoietins, the natural ligands of Tie2, modulate Tie2-dependent signaling, which in turn regulates the survival and
Martin, V., Liu, D., Fueyo, J., Gomez-Manzano, C.   +3 more
openaire   +4 more sources

Tie2 protects the vasculature against thrombus formation in systemic inflammation

Journal of Clinical Investigation, 2019
Disordered coagulation contributes to death in sepsis and lacks effective treatments. Existing markers of disseminated intravascular coagulation (DIC) reflect its sequelae rather than its causes, delaying diagnosis and treatment.
Shapiro, Nathan, Schulman, Sol, Chaudhry, Sharjeel, Libermann, Towia, De Ceunynck, Karen, Chen, Xiuying, Gu, Xuesong, Lu, Shulin, Christiani, David, Parikh, &, Flaumenhaft, Robert, Higgins, Sarah, Kellum, John   +12 more
core   +2 more sources