The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling. [PDF]
PLoS ONE, 2012 Angiopoietin-1 (Ang1) signals via the receptor tyrosine kinase Tie2 which exists in complex with the related protein Tie1 at the endothelial cell surface.
Harprit Singh +3 more
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Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism
Biology Open, 2014 In this study, we have identified a novel member of the AMPK family, namely Sucrose non-fermenting related kinase (Snrk), that is responsible for maintaining cardiac metabolism in mammals. SNRK is expressed in the heart, and brain, and in cell types such
Stephanie M. Cossette +16 more
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Клиническая онкогематология, 2014 This review focuses on association between the selectivity of Bcr-Abl kinase inhibitors and the spectrum of their adverse effects during treatment of patients with chronic myeloid leukemia.
A. A. Zeifman +3 more
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Elucidating the effect of deferoxamine, a hypoxia mimetic agent, on angiogenesis restoration in endothelial progenitor cells (EPCs) from diabetic mice [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Diabetes increases the risk of heart disease and stroke, primarily through endothelial cell dysfunction and vascular damage. These vascular complications are partly due to defects in endothelial progenitor cells (EPCs).
Vahid Siavashi +4 more
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Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer. [PDF]
PLoS ONE, 2014 Reports demonstrate the role of M-CSF (CSF1) in tumor progression in mouse models as well as the prognostic value of macrophage numbers in breast cancer patients.
Mary A Forget +10 more
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Sex differences and loss of Tie2
, 2023 The endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males. However, sexual dimorphism of the endothelium has not been taken into account.
Brom, Dr.ing. C.E. van den (Amsterdam UMC) ORCID=0000-0002-0886-1388
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Tek (Tie2) is not required for cardiovascular development in zebrafish [PDF]
Development, 2020 ABSTRACT Angiopoietin/TIE signalling plays a major role in blood and lymphatic vessel development. In mouse, Tek (previously known as Tie2) mutants die prenatally due to a severely underdeveloped cardiovascular system. In contrast, in zebrafish, previous studies have reported that although embryos injected with tek morpholinos (MOs ...
Zhen Jiang +4 more
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Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis
BMC Biology, 2018 Background Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activation of integrins by Tie2 ...
Tomer Shlamkovich +4 more
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Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype. [PDF]
PLoS ONE, 2014 Angiopoietin (Ang) -1 and -2 and their receptor Tie2 play critical roles in regulating angiogenic processes during development, homeostasis, tumorigenesis, inflammation and tissue repair.
Samuel García +9 more
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Angiopoietins and Tie2 in vascular inflammation [PDF]
Current Opinion in Hematology, 2017 Purpose of review As a subset of the organism-wide reaction to severe infection, the host vascular response has received increasing attention in recent years. The transformation that small blood vessels undergo to facilitate the clearance of pathogens may become harmful to the host if it occurs too broadly or if it is sustained
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