Elucidating the effect of deferoxamine, a hypoxia mimetic agent, on angiogenesis restoration in endothelial progenitor cells (EPCs) from diabetic mice [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Diabetes increases the risk of heart disease and stroke, primarily through endothelial cell dysfunction and vascular damage. These vascular complications are partly due to defects in endothelial progenitor cells (EPCs).
Vahid Siavashi +4 more
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Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and recruitment in a mouse model of breast cancer. [PDF]
PLoS ONE, 2014 Reports demonstrate the role of M-CSF (CSF1) in tumor progression in mouse models as well as the prognostic value of macrophage numbers in breast cancer patients.
Mary A Forget +10 more
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Pharmacological Tie2 activation in kidney transplantation [PDF]
World Journal of Transplantation, 2016 To investigate the therapeutic potential of vasculotide (VT) - a Tie2 activating therapeutic - in kidney transplantation.We performed a murine MHC-mismatched renal transplant model (C57Bl/6 male into Balb/c female) with 60 min cold and 30 min warm ischemia time. 500 ng VT was administered i.p. to donor mice 1 h before organ removal.
Thamm, Kristina +6 more
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Targeting the Tie2/Tek Receptor in Astrocytomas [PDF]
The American Journal of Pathology, 2004 Tie2 is an endothelial cell-specific receptor tyrosine kinase, whose activation is positively and negatively modulated by angiopoietin-1 and angiopoietin-2, respectively. Angiopoietin-mediated modulation of Tie2 activation contributes to normal vessel development and stability, however, its role in tumor angiogenesis is not well known.
Gelareh, Zadeh +5 more
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Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis
BMC Biology, 2018 Background Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activation of integrins by Tie2 ...
Tomer Shlamkovich +4 more
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Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype. [PDF]
PLoS ONE, 2014 Angiopoietin (Ang) -1 and -2 and their receptor Tie2 play critical roles in regulating angiogenic processes during development, homeostasis, tumorigenesis, inflammation and tissue repair.
Samuel García +9 more
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Angiopoietins and Tie2 in vascular inflammation [PDF]
Current Opinion in Hematology, 2017 Purpose of review As a subset of the organism-wide reaction to severe infection, the host vascular response has received increasing attention in recent years. The transformation that small blood vessels undergo to facilitate the clearance of pathogens may become harmful to the host if it occurs too broadly or if it is sustained
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Tek (Tie2) is not required for cardiovascular development in zebrafish [PDF]
Development, 2020 ABSTRACT Angiopoietin/TIE signalling plays a major role in blood and lymphatic vessel development. In mouse, Tek (previously known as Tie2) mutants die prenatally due to a severely underdeveloped cardiovascular system. In contrast, in zebrafish, previous studies have reported that although embryos injected with tek morpholinos (MOs ...
Zhen Jiang +4 more
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A preliminary study on the pathogenesis of venous malformations caused by Tie2-L914F mutations in endothelial cells [PDF]
Kouqiang yixueObjective To investigate the effects of TEK receptor tyrosine kinase (Tie2) L914F mutation on the biological behavior of vascular endothelial cells and the changes of related signaling pathways in patients with venous malformations.
QI Yuchen, HUANG Jiadong, LI Tianyi, LENG Chunru, SI Yameng
doaj +1 more source
Differential expression of Tie2 receptor and VEGFR2 by endothelial clones derived from isolated bovine mononuclear cells. [PDF]
PLoS ONE, 2012 The purpose of these experiments was to evaluate the expression of endothelial markers, such as Tie2 and VEGFR2 in endothelial cells derived from blood mononuclear endothelial progenitor cells.
Una Adamcic +2 more
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