Results 41 to 50 of about 30,973 (211)

Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

eLife, 2016
Mechanisms underlying the vein development remain largely unknown. Tie2 signaling mediates endothelial cell (EC) survival and vascular maturation and its activating mutations are linked to venous malformations.
Man Chu, Taotao Li, Bin Shen, Xudong Cao, Haoyu Zhong, Luqing Zhang, Fei Zhou, Wenjuan Ma, Haijuan Jiang, Pancheng Xie, Zhengzheng Liu, Ningzheng Dong, Ying Xu, Yun Zhao, Guoqiang Xu, Peirong Lu, Jincai Luo, Qingyu Wu, Kari Alitalo, Gou Young Koh, Ralf H Adams, Yulong He   +21 more
doaj   +1 more source

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

, 2008
The receptor tyrosine kinase Tie2, and its activating ligand Angiopoietin-1 (Ang1), are required for vascular remodelling and vessel integrity, whereas Ang2 may counteract these functions.
Juho Miettinen, Alitalo, Kari, Deutsch, Urban, Mark Winderlich, Koh, Gou Young, Miettinen, Juho, Vestweber, Dietmar, Saharinen, Pipsa, Astrid Nottebaum, Pipsa Saharinen, Urban Deutsch, Eklund, Lauri, Olsen, Bjorn R, Kari Alitalo, Lauri Eklund, Dietmar Vestweber, Andrey Anisimov, Anisimov, Andrey, Gou Young Koh, Riikka Wirkkala, Wirkkala, Riikka, Nottebaum, Astrid, Bjorn R. Olsen, Winderlich, Mark, Olsen, Bjorn R.   +24 more
core   +1 more source

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species

JOR Spine, 2018
Background Recently, Tie2/TEK receptor tyrosine kinase (Tie2 or syn. angiopoietin‐1 receptor) positive nucleus pulposus progenitor cells were detected in human, cattle, and mouse.
Daisuke Sakai, Jordy Schol, Frances C. Bach, Adel Tekari, Nobuho Sagawa, Yoshihiko Nakamura, Samantha C.W. Chan, Tomoko Nakai, Laura B. Creemers, Daniela A. Frauchiger, Rahel D. May, Sibylle Grad, Masahiko Watanabe, Marianna A. Tryfonidou, Benjamin Gantenbein   +14 more
doaj   +1 more source

Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression. [PDF]

PLoS ONE, 2013
Tight regulation of vascular permeability is necessary for normal development and deregulated vascular barrier function contributes to the pathogenesis of various diseases, including acute respiratory distress syndrome, cancer and inflammation.
Tadanori Mammoto, Elisabeth Jiang, Amanda Jiang, Yongbo Lu, Aimee M Juan, Jing Chen, Akiko Mammoto   +6 more
doaj   +1 more source

Early vessel destabilization mediated by Angiopoietin-2 and subsequent vessel maturation via Angiopoietin-1 induce functional neovasculature after ischemia. [PDF]

, 2013
We assessed whether Angiopoietin-2 (Ang2), a Tie2 ligand and partial antagonist of Angiopoietin-1 (Ang1), is required for early vessel destabilization during postischemic angiogenesis, when combined with vascular growth factors.
Di Qin (107446), Seungmin Lee (68256), Qin, Di, Christian Kupatt (402864), Rabea Hinkel, Trenkwalder, Teresa, Rabea Hinkel (402865), Deindl, Elisabeth, Chillo, Omary, Teresa Trenkwalder (402861), Seungmin Lee, Christian Kupatt, Omary Chillo, Lee, Seungmin, Omary Chillo (402862), Kupatt, Christian, Elisabeth Deindl (402863), Di Qin, Hinkel, Rabea, Teresa Trenkwalder, Elisabeth Deindl   +20 more
core   +2 more sources

Phosphorylation of Tie2 Endodomain.

, 2013
A Endothelial cells were incubated for 24 h in the absence of presence of PMA, as indicated, before stimulation with Ang1 for 30 min. Cell lysates were resolved by SDS/PAGE, transferred to nitrocellulose and probed for phospho-Tie2 (pTie2) and Tie2 as ...
Tania M. Hansen (336147), Nicholas P. J. Brindle (336149), Harprit Singh (336144), Nisha Patel (336148)   +3 more
core   +1 more source

Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice

Biomedicines, 2023
In Duchenne muscular dystrophy (DMD), angiogenesis appears to be attenuated. Local administration of angiopoietin 1 (Ang1) has been shown to reduce inflammation, ischemia, and fibrosis in DMD mice.
Yiming Lin, Andrew McClennan, Lisa Hoffman   +2 more
doaj   +1 more source

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

Characterization of Tie2-hsEH mice.

, 2013
A. Schematic of the Tie2-hsEH transgenic construct used to generate mice used in this study. B. Sections of WT (left) and Tie2-hsEH (right) mouse brains immunolabeled for human sEH showing sEH in capillaries and large vessels in Tie2-hsEH. Inserts, blood
Darryl C. Zeldin (16449), Craig R. Lee (400783), Wenri Zhang (400781), Matthew L. Edin (200313), Catherine M. Davis (400782), Nabil J. Alkayed (400784)   +5 more
core   +1 more source

Shear stress control of vascular leaks and atheromas through Tie2 activation by VE‐PTP sequestration

EMBO Molecular Medicine, 2023
Vascular endothelial protein tyrosine phosphatase (VE‐PTP) influences endothelial barrier function by regulating the activation of tyrosine kinase receptor Tie2.
Keisuke Shirakura, Peter Baluk, Astrid F Nottebaum, Ute Ipe, Kevin G Peters, Donald M McDonald, Dietmar Vestweber   +6 more
doaj   +1 more source