Results 61 to 70 of about 30,973 (211)

Caracterización del eje ANGPT1 / TIE2 en la dormancia de las células cancerosas

, 2020
After arriving in bone, cancer cells can enter a dormancy state that can last for years, during which they are resistant to treatment. The bone microenvironment induces dormancy via mechanisms similar to the ones of hematopoietic stem cells (HSC).
FLORIAN CHRISTOF LAURENZ DRESCHER
core  

Correction to: Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells [PDF]

, 2019
Following publication of the original article in Stem Cell Research & Therapy [1], we would like to alert the reader that the immune-histological sections shown in Figure 2 bottom line are mistakenly the images from an experiment using a different Tie2 ...
Daisuke Sakai, Benjamin Gantenbein, Adel Tekari, Grad, Sibylle, Gantenbein, Benjamin, Sakai, Daisuke, Samantha C. W. Chan, Sibylle Grad, Tekari, Adel, Chan, Samantha C.W.   +9 more
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The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

C16 Peptide Promotes Vascular Growth and Reduces Inflammation in a Neuromyelitis Optica Model

Frontiers in Pharmacology, 2019
The goal of this study was to elucidate the mechanism of action of C16, a laminin-1 peptide that competes with αvβ3 for integrin binding, in treating neuromyelitis optica (NMO).
Haohao Chen, Xiaoxiao Fu, Jinzhan Jiang, Shu Han   +3 more
doaj   +1 more source

Dysregulated TIE‐2 expression is associated with blood‐brain barrier leakiness and Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Ince et al., have analysed TIE‐1 and ‐2 expression in human brain tissue, including microvessel‐enriched fractions (MVF) and covering a spectrum of AD‐associated pathology, and in CSF from independent cohorts spanning a clinical spectrum from normal cognition to AD.
Selvi Ince, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Carey Gleason, Barbara B. Bendlin, Ozioma Okonkwo, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Seth Love, J. Scott Miners   +12 more
wiley   +1 more source

Tie2 as a novel key factor of microangiopathy in systemic sclerosis

Arthritis Research & Therapy, 2017
Background The angiopoietin(Ang)/Tie2 system is a key regulator of vascular biology. The expression of membrane bound (mb) Tie2 and Ang-1 ensures vessel stability, whereas Ang-2, inducible by vascular endothelial growth factor (VEGF), hypoxia, and ...
Falk Moritz, Janine Schniering, Jörg H. W. Distler, Renate E. Gay, Steffen Gay, Oliver Distler, Britta Maurer   +6 more
doaj   +1 more source

An engineered tetra-valent antibody fully activates the Tie2 receptor with comparable potency to its natural ligand angiopoietin-1

Scientific Reports, 2021
Activation of the tyrosine kinase with Ig and epidermal growth factor homology domain 2 (Tie2) receptor by angiopoietin-1 (Ang1) is critical for vascular stabilization: it promotes survival signal transduction via auto-phosphorylation and reduces ...
Yukari Koya, Hiromi Nara, Shigenori Yagi, Chihoko Ueno, Masazumi Kamohara   +4 more
doaj   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Pulmonary gene expression of the endothelial angiopoietin/Tie2 system.

, 2023
Pulmonary gene expression of angiopoietin-1 (A), angiopoietin-2 (B), Tie2 (C), Tie1 (D) and vascular endothelial protein tyrosine phosphatase (VE-PTP; E) in Tie2+/+ male (white bars), Tie2+/+ female (grey bars), Tie2+/- male (striped white bars) and Tie2+
Anoek L. I. van Leeuwen (8839811), Elise Beijer (17403462), Grietje Molema (64356), Roselique Ibelings (17403465), Matijs van Meurs (358888), Charissa E. van den Brom (3156441), Joris J. T. H. Roelofs (9302018), Nicole A. M. Dekker (10807289), Marjolein R. A. van der Steen (17403468)   +8 more
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Circulating markers of the endothelial angiopoietin/Tie2 system.

, 2023
Circulating levels of angiopoietin-1 (A), angiopoietin-2 (B), angiopoietin-2/1 ratio (C) and soluble Tie2 (D) in plasma of Tie2+/+ male (white bars), Tie2+/+ female (grey bars), Tie2+/- male (striped white bars) and Tie2+/- female (striped grey bars ...
Anoek L. I. van Leeuwen (8839811), Elise Beijer (17403462), Grietje Molema (64356), Roselique Ibelings (17403465), Matijs van Meurs (358888), Charissa E. van den Brom (3156441), Joris J. T. H. Roelofs (9302018), Nicole A. M. Dekker (10807289), Marjolein R. A. van der Steen (17403468)   +8 more
core   +1 more source