Results 61 to 70 of about 33,818 (248)

DPSCs treated by TGF-β1 regulate angiogenic sprouting of three-dimensionally co-cultured HUVECs and DPSCs through VEGF-Ang-Tie2 signaling

Stem cell research & therapeutics, 2021
Background Maintaining the stability and maturation of blood vessels is of paramount importance for the vessels to carry out their physiological function.
Yuchen Zhang, Junqing Liu, T. Zou, Y. Qi, B. Yi, Waruna Lakmal Dissanayaka, Chengfei Zhang   +6 more
semanticscholar   +1 more source

Adjunctive therapy with the Tie2 agonist Vasculotide reduces pulmonary permeability in Streptococcus pneumoniae infected and mechanically ventilated mice

Scientific Reports, 2022
Community acquired pneumonia, mainly caused by Streptococcus pneumoniae (S.pn.), is a common cause of death worldwide. Despite adequate antibiotic therapy, pneumococcal pneumonia can induce pulmonary endothelial hyperpermeability leading to acute lung ...
A. Lask, B. Gutbier, O. Kershaw, G. Nouailles, A. Gruber, H. Müller-Redetzky, Steven Chackowicz, Douglas A. Hamilton, P. van Slyke, M. Witzenrath   +9 more
semanticscholar   +1 more source

Angiopoietin receptor Tie2 is required for vein specification and maintenance via regulating COUP-TFII

eLife, 2016
Mechanisms underlying the vein development remain largely unknown. Tie2 signaling mediates endothelial cell (EC) survival and vascular maturation and its activating mutations are linked to venous malformations.
Man Chu, Taotao Li, Bin Shen, Xudong Cao, Haoyu Zhong, Luqing Zhang, Fei Zhou, Wenjuan Ma, Haijuan Jiang, Pancheng Xie, Zhengzheng Liu, Ningzheng Dong, Ying Xu, Yun Zhao, Guoqiang Xu, Peirong Lu, Jincai Luo, Qingyu Wu, Kari Alitalo, Gou Young Koh, Ralf H Adams, Yulong He   +21 more
doaj   +1 more source

Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression. [PDF]

PLoS ONE, 2013
Tight regulation of vascular permeability is necessary for normal development and deregulated vascular barrier function contributes to the pathogenesis of various diseases, including acute respiratory distress syndrome, cancer and inflammation.
Tadanori Mammoto, Elisabeth Jiang, Amanda Jiang, Yongbo Lu, Aimee M Juan, Jing Chen, Akiko Mammoto   +6 more
doaj   +1 more source

Gene expression analysis of Tek/Tie2 signaling [PDF]

Physiological Genomics, 2005
The elaboration of the vasculature during embryonic development involves restructuring of the early vessels into a more complex vascular network. Of particular importance to this vascular remodeling process is the requirement of the Tek/Tie2 receptor tyrosine kinase.
Stephen H, Chen, Yael, Babichev, Natalie, Rodrigues, Daniel, Voskas, Ling, Ling, Vicky P K H, Nguyen, Daniel J, Dumont   +6 more
openaire   +2 more sources

Tie2+ Cells of the Bovine Nucleus Pulposus are Progenitor Cells Capable of Differentiating into Osteocytes and Adipocytes

Global Spine Journal, 2015
Introduction The intervertebral disc (IVD) has a limited regenerative potential and low back pain represents a leading cause of disability. 1 IVD repair strategies require an appropriate cell source that is able to regenerate the damaged tissue such as ...
Adel Tekari, Samantha Chan, Karin Wuertz, Daisuke Sakai, Lorin M. Benneker, Sibylle Grad, Benjamin Gantenbein   +6 more
doaj   +1 more source

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species

JOR Spine, 2018
Background Recently, Tie2/TEK receptor tyrosine kinase (Tie2 or syn. angiopoietin‐1 receptor) positive nucleus pulposus progenitor cells were detected in human, cattle, and mouse.
Daisuke Sakai, Jordy Schol, Frances C. Bach, Adel Tekari, Nobuho Sagawa, Yoshihiko Nakamura, Samantha C.W. Chan, Tomoko Nakai, Laura B. Creemers, Daniela A. Frauchiger, Rahel D. May, Sibylle Grad, Masahiko Watanabe, Marianna A. Tryfonidou, Benjamin Gantenbein   +14 more
doaj   +1 more source

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

, 2008
The receptor tyrosine kinase Tie2, and its activating ligand Angiopoietin-1 (Ang1), are required for vascular remodelling and vessel integrity, whereas Ang2 may counteract these functions.
Juho Miettinen, Alitalo, Kari, Deutsch, Urban, Mark Winderlich, Koh, Gou Young, Miettinen, Juho, Vestweber, Dietmar, Saharinen, Pipsa, Astrid Nottebaum, Pipsa Saharinen, Urban Deutsch, Eklund, Lauri, Olsen, Bjorn R, Kari Alitalo, Lauri Eklund, Dietmar Vestweber, Andrey Anisimov, Anisimov, Andrey, Gou Young Koh, Riikka Wirkkala, Wirkkala, Riikka, Nottebaum, Astrid, Bjorn R. Olsen, Winderlich, Mark, Olsen, Bjorn R.   +24 more
core   +1 more source

Correction to: Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells [PDF]

, 2019
Following publication of the original article in Stem Cell Research & Therapy [1], we would like to alert the reader that the immune-histological sections shown in Figure 2 bottom line are mistakenly the images from an experiment using a different Tie2 ...
Daisuke Sakai, Benjamin Gantenbein, Adel Tekari, Grad, Sibylle, Gantenbein, Benjamin, Sakai, Daisuke, Samantha C. W. Chan, Sibylle Grad, Tekari, Adel, Chan, Samantha C.W.   +9 more
core   +1 more source

Role of Angiopoietin/Tie2 System in Sepsis: A Potential Therapeutic Target

Clinical and applied thrombosis/hemostasis
Sepsis is a disorder of host response caused by severe infection that can lead to life-threatening organ dysfunction. There is no specific treatment for sepsis. Although there are many different pathogens that can cause sepsis, endothelial dysfunction is
Yawen Chi, Sihan Yu, Jia Yin, Danyan Liu, Mengke Zhuo, Xu Li   +5 more
semanticscholar   +1 more source