Results 91 to 100 of about 33,818 (248)

Safety Profile of Sclerosing Agents in the Management of Low‐Flow Vascular Malformations of the Head and Neck—A Systematic Review

Head &Neck, EarlyView.
ABSTRACT Background Low‐flow vascular malformations (LFVMs) of the head and neck, including venous and lymphatic malformations, represent a heterogeneous group of congenital anomalies frequently requiring intervention due to functional and esthetic impairment.
Riccardo Nocini, Carlotta Muneretto, Athena E. Arsie, Valerio Arietti, Benedetta Lorenzon, Alessandra Cinotti, Giacomo Colletti   +6 more
wiley   +1 more source

Tie2 heterozygote deficient mice (Tie2+/−) express less total Tie2 and phosphorylated Tie2 (p-Tie2) content compared to wild-type mice in the highly vascularized beds of skeletal muscle, heart and lung.

, 2012
(a) Western immunoblots showing Tie2 (140 kDa) and β-actin (47 kDa) expression in Tie2 heterozygote deficient (Tie2+/−) and wild-type (WT) mouse heart, skeletal muscle and lungs. (b) Western immunoblot of phophorylated Tie2 (140 kDa) and β-actin from non-
Michael Lekas (134183), Poli Lekas (134187), Yupu Deng (79030), Shirley H. J. Mei (134191), Daniel J. Dumont (103749), Duncan J. Stewart (125330)   +5 more
core   +1 more source

Renal gene expression of the endothelial angiopoietin/Tie2 system.

, 2023
Renal gene expression of angiopoietin-1 (A), angiopoietin-2 (B), Tie2 (C), Tie1 (D) and vascular endothelial protein tyrosine phosphatase (VE-PTP; E) in Tie2+/+ male (white bars), Tie2+/+ female (grey bars), Tie2+/- male (striped white bars) and Tie2 ...
Anoek L. I. van Leeuwen (8839811), Elise Beijer (17403462), Grietje Molema (64356), Roselique Ibelings (17403465), Matijs van Meurs (358888), Charissa E. van den Brom (3156441), Joris J. T. H. Roelofs (9302018), Nicole A. M. Dekker (10807289), Marjolein R. A. van der Steen (17403468)   +8 more
core   +1 more source

Tie2 as a novel key factor of microangiopathy in systemic sclerosis

Arthritis Research & Therapy, 2017
Background The angiopoietin(Ang)/Tie2 system is a key regulator of vascular biology. The expression of membrane bound (mb) Tie2 and Ang-1 ensures vessel stability, whereas Ang-2, inducible by vascular endothelial growth factor (VEGF), hypoxia, and ...
Falk Moritz, Janine Schniering, Jörg H. W. Distler, Renate E. Gay, Steffen Gay, Oliver Distler, Britta Maurer   +6 more
doaj   +1 more source

Blockade of angiopoietin-2/Tie2 signaling pathway specifically promotes inflammation-induced angiogenesis in mouse cornea [PDF]

International Journal of Ophthalmology, 2017
AIM: To investigate angiopoietin-2 (Ang-2)/Tie2 signaling pathway involving in inflammatory angiogenesis. METHODS: Three interrupted 11-0 nylon sutures were placed into the corneal stroma of BALB/c mice (6wk old) to induce inflammatory ...
Zhi-Xin Yan, Yi Luo, Ning-Fei Liu
doaj   +1 more source

Adverse Health Events in Chronic Myeloid Leukaemia Patients Treated With Tyrosine Kinase Inhibitors 2009–2019: A Real‐World Study From the UK's Haematological Malignancy Research Network

International Journal of Cancer, EarlyView.
Although tyrosine kinase inhibitors (TKIs) improve chronic myeloid leukemia (CML) outcome, long‐term effects remain unclear, particularly in real‐world settings. Here, the authors examined morbidity and mortality in CML patients treated with TKIs between 2009 and 2019 in the United Kingdom.
Eleanor Kane, Alexandra Smith, Debra Howell, Catherine Cargo, Kate Rothwell, Simone Green, Russell Patmore, Eve Roman   +7 more
wiley   +1 more source

Predictive Biomarkers in Metastatic Colorectal Cancer Patients Treated With Bevacizumab: A Turkish Oncology Group (TOG) Study

International Journal of Cancer, EarlyView.
Bevacizumab added to systemic chemotherapy remains a cornerstone of metastatic colorectal cancer treatment, but its effectiveness is variable. Tumors can bypass the VEGF blockade by activating other pro‐angiogenic pathways, hampering the identification of predictive biomarkers.
Büsra Akay Hacan, Fatma Gizem Sonugür, Müge Öçal, Cansu Babahan, Samira Abgarmi, Ülkü Yalçıntaş Arslan, Mehmet Ali Şendur, Ahmet Demirkazık, Güngör Utkan, Hakan Akbulut   +9 more
wiley   +1 more source

The Angiopoietin-Tie2 Signaling Axis in Systemic Inflammation [PDF]

Journal of the American Society of Nephrology, 2017
Systemic inflammation is a hallmark of commonly encountered diseases ranging from bacterial sepsis to sterile syndromes such as major trauma. Derangements in the host vasculature contribute to the cardinal manifestations of sepsis in profound ways. Recent studies of control pathways regulating the vascular endothelium have illuminated how this single ...
openaire   +2 more sources

Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function. [PDF]

PLoS ONE, 2011
Development of the hematopoietic and endothelial lineages derives from a common mesodermal precursor, the Flk1(+) hemangioblast. However, the signaling pathways that regulate the development of hematopoietic and endothelial cells from this common ...
Xuehui Yang, Yan Gong, Robert Friesel
doaj   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source