Results 91 to 100 of about 30,973 (211)
DHCR24 Alleviates DNA Damage in Senescent Vascular Endothelial Cells via ENKUR/Ca2+ Signaling
Aging Cell, Volume 25, Issue 9, September 2026.In senescent vascular endothelial cells, DHCR24 deficiency triggers ENKUR‐dependent Ca2+ overload, which in turn induces endoplasmic reticulum stress and mitochondrial dysfunction, ultimately exacerbating oxidative stress and DNA damage. ABSTRACT DNA damage is considered one of the major contributors to aging.
Han Li +11 more
wiley +1 more source
Dimerization of Tie2 mediated by its membrane-proximal FNIII domains
, 2017 Significance Tie2 is a receptor tyrosine kinase with important roles in vascular development. Inhibiting Tie2 may impair tumor angiogenesis, whereas activating Tie2 may be beneficial in sepsis and inflammation. To modulate Tie2 therapeutically,
Mark A. Lemmon +2 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 18, Page 5516-5540, September 2026.Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn +11 more
wiley +1 more source
, 2007 A critical role for Tie1, an orphan endothelial receptor, in blood vessel morphogenesis has emerged from mutant mouse studies. Moreover, it was recently demonstrated that certain angiopoietin (Ang) family members can activate Tie1.
Sukhatme, Vikas P. +19 more
core +1 more source
Endothelial Function Is Associated With Incident Diabetes Mellitus: The ELSA‐Brasil Cohort Study
Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8103-8112, September 2026.ABSTRACT Aims Diabetes mellitus is associated with endothelial dysfunction, but the bidirectional nature of this relationship remains debated. We aimed to evaluate the association between microvascular endothelial function and incident diabetes in Brazilian adults and to assess potential effect modification by obesity status.
Karina P. M. P. Martins +7 more
wiley +1 more source
안구 혈관 질환에서 Angiopoietin-Tie2 신호전달체계의 역할
, 2018 학위논문(박사) - 한국과학기술원 : 의과학대학원, 2018.2,[v, 128 p. :]Part I. Role of Angiopoietin-Tie2 System in Schlemm’s Canal Integrity and Glaucomagenesis Elevated intraocular pressure (IOP) because of increased resistance to aqueous humor outflow (AHO) is a main cause ...
Jaeryung, Kim
core +1 more source
The Journal of Clinical InvestigationThe role of endothelial dysfunction in tubulointerstitial fibrosis associated with chronic kidney disease (CKD) is not well understood. In this study, we demonstrate that the activation of the endothelial tyrosine kinase TIE2 alleviates renal pathology ...
Riikka Pietilä +6 more
doaj +1 more source
Assessing the therapeutic potential of PDE‐5 inhibitors in adults: Insights from a multi‐omics study
Physiological Reports, Volume 14, Issue 18, September 2026.Abstract Phosphodiesterase‐5 inhibitors have beneficial pleiotropic effects and hold promise as adjuvant treatments for cancer, dementia, and other disorders. Sixteen men and women aged 50–60 were administered daily sildenafil/tadalafil for 1 month. We characterized molecular signatures of sildenafil/tadalafil treatment via analyses and multi‐omics ...
Kristen A. McGovern +14 more
wiley +1 more source
BMC CancerBackground Anti-angiogenic, VEGF inhibitors (VEGFi) increase progression-free survival (PFS) and, in some cases, overall survival in many solid tumours. However, their use has been compromised by a lack of informative biomarkers.
Margherita Carucci +22 more
doaj +1 more source
Leukemia Research ReportsIntroduction: Tie2 is a receptor tyrosine kinase and regulates angiogenesis and vascular quiescence. Given that Tie2 modulates microvascular density in cancer, we hypothesized that deletion of Tie2 in blood cells can inhibit progression of ...
M. Hirayama +3 more
doaj +1 more source