Results 111 to 120 of about 30,973 (211)

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations [PDF]

Venous malformations (VMs) are vascular anomalies lacking curative treatments, often caused by somatic PIK3CA mutations that hyperactivate the PI3Kα-AKT-mTOR signaling pathway.
Boon, L.M., Vikkula, Miikka, De Roo, A.K., Grosso, A.R., De Roo, An Katrien, Schoofs, Hans, De Roo, An-Katrien, Hägerling, R., Vikkula, M., Petkova, Milena, Andrade, J., Kraft, Marle, Mäkinen, T., Boon, Laurence M., Hägerling, René, Andrade, Jorge, Kapp, Friedrich G., Potente, M., Makinen, Taija, Kraft, M., Petkova, M., Kapp, F.G., Grosso, Ana Rita, Benedito, Rui, Benedito, R., Potente, Michael, Schoofs, H.   +26 more
core   +1 more source

CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity

iScience
Summary: The Ets transcription factors induce the expression of Tie2 and VE-cadherin. However, the regulation of these factors remains unknown. Here, we found that the gene encoding the Ets factor Elf2 was hypermethylated in Camkkβ-deficient (Camkkβ ...
Dong-Mei Wang, Juan Yang, Mohammad Owais Ansari, Zarema Arbieva, Mark Maienschein-Cline, Viswanathan Natarajan, Asrar B. Malik, Chinnaswamy Tiruppathi   +7 more
doaj   +1 more source

Effects of VEGF, PMA and TNFá on Cellular Tie2 Activation.

, 2013
HUVEC were treated with VEGF A, PMA B or TNFα C for 0, 0.5 or 24 h to induce Tie1 and Tie2 ectodomain cleavage followed by 200 ng/ml Ang1 for 30 min.
Tania M. Hansen (336147), Nicholas P. J. Brindle (336149), Harprit Singh (336144), Nisha Patel (336148)   +3 more
core   +1 more source

Tie2 protects the vasculature against thrombus formation in systemic inflammation

, 2019
Disordered coagulation contributes to death in sepsis and lacks effective treatments. Existing markers of disseminated intravascular coagulation (DIC) reflect its sequelae rather than its causes, delaying diagnosis and treatment.
Shapiro, Nathan, Schulman, Sol, Chaudhry, Sharjeel, Libermann, Towia, De Ceunynck, Karen, Chen, Xiuying, Gu, Xuesong, Lu, Shulin, Christiani, David, Parikh, &, Flaumenhaft, Robert, Higgins, Sarah, Kellum, John   +12 more
core   +1 more source

Roles of angiopoietin and TIE2 receptor angiogenesis

Ensho Saisei, 2001
Vascular development consists of two processes termed vasculogenesis and angiogenesis. The system of TIE 2-Angiopoietin (Ang) is involved in the later, angiogenesis. It has been demonstrated that the function of TIE 2 is associated with adhesion and dissociation between endothelial cells and mural cells, and survival, apoptosis, and chemotaxis of ...
openaire   +1 more source

Tie2, a journey from normal angiogenesis to cancer and beyond [PDF]

, 2008
The tyrosine kinase receptor Tie2 was initially identified as a specific vascular growth factor that governed several properties of endothelial cells under both physiological and pathological conditions.
Fueyo, J., Gomez-Manzano, C., Martin, V., Liu, D.   +3 more
core  

Structure of the Tie2 RTK Domain [PDF]

Structure, 2000
Shewchuk, Lisa M, Hassell, Anne M, Ellis, Byron, Holmes, W.D, Davis, Roderick, Horne, Earnest L, Kadwell, Sue H, McKee, David D, Moore, John T   +8 more
openaire   +1 more source

Exploring a Novel Spheroid 3D Cell Culture System for Tie2+ Nucleus Pulposus Cells of the Intervertebral Disc [PDF]

Introduction Low back pain (LBP) is a big problem in today's Western European society1. LBP impacts the patient's quality of life and places an immense burden on the healthcare system worldwide2,3. Degeneration of the intervertebral disc (IVD) is one of
Rüttimann, Silvan, Gantenbein, Benjamin, Schlagenhof, Leon, Ille, Fabian   +3 more
core   +1 more source

Endothelial-specific Tie2 knockout mouse model - Tie2fl/fl;Cdh5-creERT2(+/−): a potent tool for inducible Tie2 deletion in vasculature across multiple organs

Background TEK receptor tyrosine kinase (Tie2) is predominantly expressed on endothelial cells and is known to play a critical role in vascular development and stability.
Shibani Pati, Callie Keane, Alpa Trivedi, Grietje Molema, Peter J. Zwiers, Byron Miyazawa   +5 more
core   +1 more source

Pathogenesis and molecular mechanisms of mutant TIE2-driven venous malformation. [PDF]

Angiogenesis
Bischoff LJ, Boscolo E.
europepmc   +1 more source