Results 111 to 120 of about 33,818 (248)

Dysregulated TIE‐2 expression is associated with blood‐brain barrier leakiness and Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Ince et al., have analysed TIE‐1 and ‐2 expression in human brain tissue, including microvessel‐enriched fractions (MVF) and covering a spectrum of AD‐associated pathology, and in CSF from independent cohorts spanning a clinical spectrum from normal cognition to AD.
Selvi Ince, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Carey Gleason, Barbara B. Bendlin, Ozioma Okonkwo, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Seth Love, J. Scott Miners   +12 more
wiley   +1 more source

Pulmonary gene expression of the endothelial angiopoietin/Tie2 system.

, 2023
Pulmonary gene expression of angiopoietin-1 (A), angiopoietin-2 (B), Tie2 (C), Tie1 (D) and vascular endothelial protein tyrosine phosphatase (VE-PTP; E) in Tie2+/+ male (white bars), Tie2+/+ female (grey bars), Tie2+/- male (striped white bars) and Tie2+
Anoek L. I. van Leeuwen (8839811), Elise Beijer (17403462), Grietje Molema (64356), Roselique Ibelings (17403465), Matijs van Meurs (358888), Charissa E. van den Brom (3156441), Joris J. T. H. Roelofs (9302018), Nicole A. M. Dekker (10807289), Marjolein R. A. van der Steen (17403468)   +8 more
core   +1 more source

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

Cancer Cell, 2005
Bone marrow-derived cells contribute to tumor angiogenesis. Here, we demonstrate that monocytes expressing the Tie2 receptor (Tie2-expressing monocytes [TEMs]) (1) are a distinct hematopoietic lineage of proangiogenic cells, (2) are selectively recruited
Michele De Palma, M. Venneri, R. Galli, Lucia Sergi Sergi, L. Politi, M. Sampaolesi, L. Naldini   +6 more
semanticscholar   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Inhibition of tyrosine kinase receptor Tie2 reverts HCV-induced hepatic stellate cell activation. [PDF]

PLoS ONE, 2014
BACKGROUND: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease (CLD) and is frequently linked to intrahepatic microvascular disorders.
Samuel Martín-Vílchez, Yolanda Rodríguez-Muñoz, Rosario López-Rodríguez, Hernández-Bartolomé, María Jesús Borque-Iñurrita, Francisca Molina-Jiménez, Luisa García-Buey, Ricardo Moreno-Otero, Paloma Sanz-Cameno   +8 more
doaj   +1 more source

Endothelial Function Is Associated With Incident Diabetes Mellitus: The ELSA‐Brasil Cohort Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetes mellitus is associated with endothelial dysfunction, but the bidirectional nature of this relationship remains debated. We aimed to evaluate the association between microvascular endothelial function and incident diabetes in Brazilian adults and to assess potential effect modification by obesity status.
Karina P. M. P. Martins, Sandhi M. Barreto, Lidyane V. Camelo, Sara T. Menezes, Naomi M. Hamburg, Maria de Fatima H. S. Diniz, Antonio L. P. Ribeiro, Luisa C. C. Brant   +7 more
wiley   +1 more source

Regulation of tie2 expression by angiopoietin--potential feedback system

, 2004
To study a potential feedback system in the angiopoietin (Ang)-Tie2 system, the authors examined effects of Ang1 and Ang2 on Tie2 expression on human umbilical vein endothelial cells (HUVECs) with or without stimulation by a potent inflammatory cytokine,
Wu, Yongqin, Hashimoto, Tomoki, Young, William, Li, Jenny, Matsumoto, Melissa, Boudreau, Nancy   +5 more
core   +1 more source

TEK/Tie2 Is a Novel Gene Involved in Endoplasmic Reticulum Stress

Journal of Pharmacological Sciences, 2010
Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of diseases such as neurodegenerative disease. In the present study, we established the ER stress–resistant SH-SY5Y cell line, and through microarray analysis, we found that TEK ...
Toru Hosoi, Taiji Tamubo, Naohiro Horie, Yasunobu Okuma, Yasuyuki Nomura, Koichiro Ozawa   +5 more
doaj   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Functional Significance of Tie2 Signaling in the Adult Vasculature

Recent Progress in Hormone Research, 2004
Abundant data now demonstrate that the growth of new blood vessels, termed angiogenesis, plays both pathological and beneficial roles in human disease. Based on these data, a tremendous effort has been undertaken to understand the molecular mechanisms that drive blood vessel growth in adult tissues.
Kevin G, Peters, Christopher D, Kontos, P Charles, Lin, Adrianne L, Wong, Prema, Rao, Liwen, Huang, Mark W, Dewhirst, Sabita, Sankar   +7 more
openaire   +2 more sources