Results 131 to 140 of about 33,818 (248)

Mechanisms of Pericyte‐Mediated Cancer Metastasis

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley   +1 more source

Tie2 mRNA and protein expression in control and Tie2 knockout mice.

, 2022
Tie2 expression levels were determined in organs of Tie2fl/fl/Cre- control mice and Tie2ΔE9 knockout mice after tamoxifen treatment by (A) RT-qPCR, and (B) ELISA. Graphs show individual values and means (black lines) ± SD (error bars).
Peter J. Zwiers (7510744), Radu V. Stan (12837195), Joachim R. Göthert (12837198), Jill Moser (4950721), Grietje Molema (64356), Matijs van Meurs (358888), Rianne M. Jongman (12837192), Timara Kuiper (7510746), Eliane R. Popa (2295178)   +8 more
core   +1 more source

Human brain pericytes protect the blood–brain barrier from triple‐negative breast cancer cells while promoting tumor aggressiveness

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Abstract The majority of breast cancer‐related deaths result from metastatic progression, especially brain metastasis, associated with the poorest prognosis. Patients with triple‐negative breast cancer (TNBC) are particularly prone to developing brain metastases.
Eloise Happernegg, Marine Carroué, Julien Cicero, Lucie Dehouck, Fumitaka Shimizu, Takashi Kanda, Chann Lagadec, Fabien Gosselet, Xuefen Le Bourhis, Maxime Culot, Robert‐Alain Toillon, Caroline Mysiorek   +11 more
wiley   +1 more source

A comparative analysis of tie2-positive IVD progenitor cells in single-cell and bulk transcriptomics. [PDF]

Introduction: Back pain and disability are often attributed to intervertebral disc (IVD) degeneration1, where current treatments are limited by an incomplete understanding of IVD biology.
Stirnimann, Anja, Schlagenhof, Leon Max, Gantenbein, Benjamin, Ille, F.   +3 more
core  

HAPLOINSUFFICIENCY OF TIE2 IN MUTATED BLOOD CELLS SUPPRESS ANGIOGENESIS IN THE BONE MARROW AND INHIBIT PROGRESSION OF MDS

Leukemia Research Reports
Introduction: Tie2 is a receptor tyrosine kinase and regulates angiogenesis and vascular quiescence. Given that Tie2 modulates microvascular density in cancer, we hypothesized that deletion of Tie2 in blood cells can inhibit progression of ...
M. Hirayama, Y. Arima, T. Suda, G. Sashida   +3 more
doaj   +1 more source

Extracellular Vesicles as Drivers of Lung Endothelial Dysfunction in ARDS: Mechanisms and Therapeutic Opportunities

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
This review summarizes how extracellular vesicles from diverse pulmonary and extrapulmonary sources contribute to endothelial dysfunction in ARDS and evaluates emerging endothelial‐targeted therapies for their potential to mitigate EV‐mediated pathogenic mechanisms.
Mohammed Yaman Al Matni, Patrick Belvitch, Steven M. Dudek, Eleftheria Letsiou   +3 more
wiley   +1 more source

Constitutive Active Mutant TIE2 Induces Enlarged Vascular Lumen Formation with Loss of Apico-basal Polarity and Pericyte Recruitment

Scientific Reports, 2019
Abnormalities in controlling key aspects of angiogenesis including vascular cell migration, lumen formation and vessel maturation are hallmarks of vascular anomalies including venous malformation (VM).
Yuqi Cai, Sandra Schrenk, Jillian Goines, George E. Davis, Elisa Boscolo   +4 more
doaj   +1 more source

Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

Science Advances, 2019
Angpt-Tie2 is essential for choriocapillary maintenance, and Tie2 activation could be a therapeutic avenue for fundamental treatment of NV-AMD. Choriocapillary loss is a major cause of neovascular age-related macular degeneration (NV-AMD).
Jaeryung Kim, J. Park, Jeongwoon Choi, Intae Park, Y. Hwang, Hosung Bae, Yongjoo Kim, WooJhon Choi, Jee Myung Yang, Sangyeul Han, Tae-Young Chung, Pilhan Kim, Y. Kubota, H. Augustin, W. Oh, G. Koh   +15 more
semanticscholar   +1 more source

Kaposiform hemangioendothelioma: Diagnosis and treatment

Pediatric Investigation, Volume 10, Issue 3, Page 269-280, June 2026.
Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian, Yuanyuan Tian, Li Wei, Zigang Xu, Li Li, Lin Ma   +5 more
wiley   +1 more source

The Underlying Mechanisms and Role of Negative Pressure Wound Therapy in Chronic Diabetic Wound Healing: A Systematic Review and Meta‐Analysis

International Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT Although Negative Pressure Wound Therapy (NPWT) has been increasingly used in wound care to improve impaired healing, there is little scientific evidence supporting its role and underlying biomolecular mechanisms. Aims of the present study are to provide a quantitative analysis of recent literature investigating NPWT in diabetic wound healing ...
Roxana Moscalu, Mihaela Moscalu, Adam J. Reid, Marco Domingos, Adam Stevens, Jason K. F. Wong   +5 more
wiley   +1 more source