Results 131 to 140 of about 27,290 (180)

The Role of Angiopoietin-2 in Post-Burn Pneumonia. [PDF]

Eur Burn J
Murray MG, Johnson RM, Plum AB, Carbajal Garcia N, Galicia KE, Brady A, Kipp M, Helenowski IB, Tschann MM, Guzior C, Gonzalez RP, Choudhry MA, Kubasiak JC.   +12 more
europepmc   +1 more source

Pharmacological modulation of circadian rhythms in brain microvasculature. [PDF]

J Cereb Blood Flow Metab
Yang Z, Kim M, Montgomery M, Lewandowski A, Ho A, Buchwald ZS, Zhang SL.   +6 more
europepmc   +1 more source

Radiosensitizing effects of silver nanoparticles targeting angiogenesis and matrix metalloproteinase signaling in triple negative breast cancer cell lines. [PDF]

Sci Rep
Montazersaheb S, Farahzadi R, Mansouri E, Jafari S, Fathi E.   +4 more
europepmc   +1 more source

The role of nucleus pulposus progenitor cells in intervertebral disc degeneration and regeneration. [PDF]

J Orthop Surg Res
Wang P, Yao Y, Chen X, Luo W, Li H, Wang D.   +5 more
europepmc   +1 more source

SUPPLEMENTARY MATERIAL_IJMS_NRF2-TIE2.docx

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Pyridinylimidazole inhibitors of Tie2 kinase

Bioorganic and Medicinal Chemistry Letters, 2007
This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.
Neil Johnson
exaly   +3 more sources

Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2–Tie2 complex

Nature Structural & Molecular Biology, 2006
The Tie receptor tyrosine kinases and their angiopoietin (Ang) ligands play central roles in developmental and tumor-induced angiogenesis. Here we present the crystal structures of the Tie2 ligand-binding region alone and in complex with Ang2. In contrast to prediction, Tie2 contains not two but three immunoglobulin (Ig) domains, which fold together ...
William A, Barton, Dorothea, Tzvetkova-Robev, Edward P, Miranda, Momchil V, Kolev, Kanagalaghatta R, Rajashankar, Juha P, Himanen, Dimitar B, Nikolov   +6 more
openaire   +2 more sources

Vaccination against TIE2 reduces atherosclerosis

Atherosclerosis, 2009
TIE2(+) cells play a crucial role in processes that are involved in atherosclerosis, such as angiogenesis. Therefore, the specific deletion of TIE2(+) cells by means of DNA vaccination may affect atherosclerosis.Cellular immunity against cells that overexpress TIE2 was established in LDLr(-/-) mice by a novel oral DNA vaccination technique, in which an
Johan Kuiper, Theo Van Berkel, Paula De Vos   +2 more
exaly   +3 more sources

Preferential activity of Tie2 promoter in arteriolar endothelium [PDF]

Journal of Cellular and Molecular Medicine, 2005
The tyrosine kinase Tie2/Tek (the receptor for angiopoietins) is considered one of the most reliable markers of the endothelial phenotype, across organisms, organs, and developmental stages. However, endothelium is intrinsically heterogeneous in origin, composition and function, presenting an arteriolar/venular asymmetry. In this regard, the expression
Nicanor Moldovan
exaly   +3 more sources