Results 211 to 220 of about 33,818 (248)

Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination

Cancers, 2021
Simple Summary The dissemination of cancer cells from their original location to distant organs where they grow, a process called metastasis, causes more than 90% of cancer deaths.
Camille L Duran, Lucia Borriello, George S Karagiannis   +2 more
exaly   +2 more sources

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Tauroursodeoxycholic Acid Alleviates Endoplasmic Reticulum Stress-Mediated Visual Deficits in Diabetic tie2-TNF Transgenic Mice via TGR5 Signaling

Journal of Ocular Pharmacology and Therapeutics, 2023
Purpose: This study evaluated if tauroursodeoxycholic acid (TUDCA) alleviates pro-inflammatory and endoplasmic reticulum (ER) stress-mediated visual deficits in diabetic tie2-TNF transgenic mice via Takeda G protein-coupled receptor 5 (TGR5) receptor ...
R. Lenin, K. Jha, Jordy Gentry, A. Shrestha, Erielle V. Culp, Thirumalini Vaithianathan, Rajashekhar Gangaraju   +6 more
semanticscholar   +1 more source

Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2–Tie2 complex

Nature Structural & Molecular Biology, 2006
The Tie receptor tyrosine kinases and their angiopoietin (Ang) ligands play central roles in developmental and tumor-induced angiogenesis. Here we present the crystal structures of the Tie2 ligand-binding region alone and in complex with Ang2. In contrast to prediction, Tie2 contains not two but three immunoglobulin (Ig) domains, which fold together ...
William A, Barton, Dorothea, Tzvetkova-Robev, Edward P, Miranda, Momchil V, Kolev, Kanagalaghatta R, Rajashankar, Juha P, Himanen, Dimitar B, Nikolov   +6 more
openaire   +2 more sources

Vaccination against TIE2 reduces atherosclerosis

Atherosclerosis, 2009
TIE2(+) cells play a crucial role in processes that are involved in atherosclerosis, such as angiogenesis. Therefore, the specific deletion of TIE2(+) cells by means of DNA vaccination may affect atherosclerosis.Cellular immunity against cells that overexpress TIE2 was established in LDLr(-/-) mice by a novel oral DNA vaccination technique, in which an
Kim L L Habets, Eva J A Van Wanrooij, Paula De Vos   +2 more
exaly   +3 more sources

Pyridinylimidazole inhibitors of Tie2 kinase

Bioorganic & Medicinal Chemistry Letters, 2007
This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.
Marcus, Semones, Yanhong, Feng, Neil, Johnson, Jerry L, Adams, Jim, Winkler, Michael, Hansbury   +5 more
openaire   +2 more sources

VEGF Induces Tie2 Shedding via a Phosphoinositide 3-Kinase/Akt–Dependent Pathway to Modulate Tie2 Signaling [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Objective— Tie2 and its ligands, the angiopoietins (Ang), are required for embryonic and postnatal angiogenesis. Previous studies have demonstrated that Tie2 is proteolytically cleaved, resulting in the production of a 75-kDa soluble receptor fragment (sTie2).
Asif Ahmed, Christopher D Kontos
exaly   +3 more sources

Preferential activity of Tie2 promoter in arteriolar endothelium [PDF]

Journal of Cellular and Molecular Medicine, 2005
The tyrosine kinase Tie2/Tek (the receptor for angiopoietins) is considered one of the most reliable markers of the endothelial phenotype, across organisms, organs, and developmental stages. However, endothelium is intrinsically heterogeneous in origin, composition and function, presenting an arteriolar/venular asymmetry. In this regard, the expression
Mirela Anghelina, Leni Moldovan, Nicanor I Moldovan   +2 more
exaly   +3 more sources

Targeting the ANGPT–TIE2 pathway in malignancy

Nature Reviews Cancer, 2010
Angiopoietins (ANGPTs) are ligands of the endothelial cell receptor TIE2 and have crucial roles in the tumour angiogenic switch. Increased expression of ANGPT2 relative to ANGPT1 in tumours correlates with poor prognosis. The biological effects of the ANGPT-TIE system are context dependent, which brings into question what the best strategy is to target
Hanhua, Huang, Abhijit, Bhat, Gary, Woodnutt, Rodney, Lappe   +3 more
openaire   +2 more sources

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment

Cancer Cell, 2016
Il-Kug Kim, Sangyeul Han, Intae Park
exaly   +2 more sources

Mechanistic Effects of Autophosphorylation on Receptor Tyrosine Kinase Catalysis:  Enzymatic Characterization of Tie2 and Phospho-Tie2

Biochemistry, 2001
Activation of receptor tyrosine kinases by autophosphorylation is one of the most common and critical transformations in signal transduction, yet its role in catalysis remains controversial. Autophosphorylation of the angiogenic receptor tyrosine kinase Tie2 was studied in terms of the autophosphorylation sites, sequence of phosphorylation at these ...
B W, Murray, E S, Padrique, C, Pinko, M A, McTigue   +3 more
openaire   +2 more sources