Results 221 to 230 of about 33,818 (248)
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Tek/Tie2 Signaling: New and Old Partners
Cancer and Metastasis Reviews, 2000A common property amongst angiogenic ligands such as the vascular endothelial growth factors and the angiopoietins is that they can elicit multiple responses depending upon the context of their expression and the presence of other growth factors. Study of the signal transduction pathways initiated by these growth factors provides insight into the ...
N, Jones, D J, Dumont
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The First Naturally Occurring Tie2 Kinase Inhibitor
Organic Letters, 2001[structure: see text] Bioassay-guided fractionation of the plant Acacia aulacocarpa, guided by a bioassay for Tie2 tyrosine kinase activity, yielded the novel triterpene 3,21-dioxo-olean-18-en-oic acid (1) as the first naturally occurring non-protein inhibitor of Tie2 kinase. The structure of 1 was assigned by analysis of spectral data.
B N, Zhou +4 more
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Optimization of triarylimidazoles for Tie2: Influence of conformation on potency
Bioorganic & Medicinal Chemistry Letters, 2007In an effort to understand the effect of N-alkylation of triarylimidazoles on Tie2 inhibition, ortho-substituted C-2 aryl analogs were synthesized to investigate the effect of different torsion angles on potency. This exercise resulted in the identification of a potent and selective tetrasubstituted imidazole that was efficacious in an animal model of ...
Neil W, Johnson +4 more
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Notoginsenoside R1 activates the Ang2/Tie2 pathway to promote angiogenesis.
Phytomedicine, 2020BACKGROUND Therapeutic angiogenesis is a novel strategy for the treatment of ischemic diseases that involves promotion of angiogenesis in ischemic tissues via the use of proangiogenic agents.
Jincheng Zhong +14 more
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Ang1 and Tie2 Are Predictive Biomarkers for Bevacizumab—Letter
Clinical Cancer Research, 2015In their interesting article published in the September 2014 issue of Clinical Cancer Research , Backen and colleagues ([1][1]) analyzed angiogenesis-related factors as predictive biomarkers in patients with ovarian cancer treated with bevacizumab.
Joseph, Ciccolini +4 more
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Production and characterization of a Tie2 agonist monoclonal antibody
Angiogenesis, 2001The Tie2 receptor and its known ligands, the angiopoietins, play a critical role in endothelial cell differentiation during the process of angiogenesis. Recent experimental observations indicate that the agonistic ligand, angiopoietin-1, can stimulate endothelial cell sprouting and act as a chemo-attractant in vitro and induce increased and enhanced ...
M J, Hansbury +4 more
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Angiopoietins and Tie2 in health and disease.
Pediatric endocrinology reviews : PER, 2006The angiopoietins are a class of growth factors that activate the Tie2 receptor and play important roles in the regulation of angiogenesis. Proper regulation of angiogenesis is required for both embryonic vascular development and physiological processes in the adult such as wound healing and the female reproductive cycle, while aberrant regulation of ...
Lu-Yuan, Li +2 more
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Targeting Tie2 and the host vascular response in sepsis
Science Translational Medicine, 2016A new therapeutic approach to a complex and dire disease—sepsis—targets a signaling molecule in the vasculature (Han et al ., this issue).
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Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
Science, 1997C. MaisonpierrePeter +13 more
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