Results 71 to 80 of about 301,934 (303)

Antibiotics induced intestinal tight junction barrier dysfunction is associated with microbiota dysbiosis, activated NLRP3 inflammasome and autophagy.

PLoS ONE, 2019
Tight junction barrier is critical to intestinal homeostasis. Applying antibiotics to treat infections is common in clinical practice, which may affect intestinal microbiota.
Yanhai Feng, Yalan Huang, Yu Wang, Pei Wang, Huapei Song, Fengjun Wang   +5 more
doaj   +1 more source

Claudin-5: gatekeeper of neurological function

Fluids and Barriers of the CNS, 2019
Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of endothelial cells lining brain blood vessels. The presence of these protein complexes in the space between endothelial cells creates a dynamic, highly regulated and
Chris Greene, Nicole Hanley, Matthew Campbell   +2 more
doaj   +1 more source

A wave function based ab initio non-equilibrium Green's function approach to charge transport

, 2005
We present a novel ab initio non-equilibrium approach to calculate the current across a molecular junction. The method rests on a wave function based description of the central region of the junction combined with a tight binding approximation for the ...
Alexander Schnurpfeil, Bo Song, Brenner D., Cuniberti G., Haug H., Lindgren I., Martin Albrecht   +6 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure

Gastroenterology Research and Practice, 2013
Brain edema in acute liver failure (ALF) remains lethal. Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored.
Wei Cui, Cui-Ming Sun, Pei Liu
doaj   +1 more source

Pre-selectable integer quantum conductance of electrochemically fabricated silver point contacts [PDF]

, 2008
The controlled fabrication of well-ordered atomic-scale metallic contacts is of great interest: it is expected that the experimentally observed high percentage of point contacts with a conductance at non-integer multiples of the conductance quantum G_0 =
Brendelberger, S., Maul, R., Obermair, Ch., Schimmel, Th., Schoen, G., Starikov, E. B., Wenzel, W., Xie, F. -Q.   +7 more
core   +3 more sources

Physiology and Function of the Tight Junction [PDF]

Cold Spring Harbor Perspectives in Biology, 2009
Understanding of tight junctions has evolved from their historical perception as inert solute barriers to recognition of their physiological and biochemical complexity. Many proteins are specifically localized to tight junctions, including cytoplasmic actin-binding proteins and adhesive transmembrane proteins.
James M, Anderson, Christina M, Van Itallie   +1 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics

Nature Communications
Cytoplasmic β- and γ-actin isoforms, along with non-muscle myosin 2 isoforms, are tightly regulated in epithelial cells and compose the actomyosin cytoskeleton at the apical junctional complex.
Marine Maupérin, Yuze Sun, Thomas Glandorf, Tabea Anne Oswald, Niklas Klatt, Burkhard Geil, Annick Mutero-Maeda, Isabelle Méan, Lionel Jond, Andreas Janshoff, Jie Yan, Sandra Citi   +11 more
doaj   +1 more source

Spatio-temporal expression pattern and role of the tight junction protein MarvelD3 in pancreas development and function

Scientific Reports, 2021
Tight junction complexes are involved in the establishment and maintenance of cell polarity and the regulation of signalling pathways, controlling biological processes such as cell differentiation and cell proliferation.
Charlotte Heymans, Ophélie Delcorte, Catherine Spourquet, Mylah Villacorte-Tabelin, Sébastien Dupasquier, Younes Achouri, Siam Mahibullah, Pascale Lemoine, Maria S. Balda, Karl Matter, Christophe E. Pierreux   +10 more
doaj   +1 more source