Results 91 to 100 of about 632,604 (307)
Molecular Dissection of Tight Junctions.
Cell Structure and Function, 1996 In epithelial and endothelial cells, the tight junction (TJ) seals cells to create a primary barrier to the diffusion of solutes across the cell sheet, and it also works as a boundary between the apical and basolateral membrane domains to create their polarization.
Tsukita, Shoichiro +2 more
openaire +3 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Honigmann-Lab-BIOTEC/Membrane-prewetting-by-condensates-tight-junction-belt-formation: Version two
Karina Pombo-García, Omar Adame-Arana, Cecilie Martin-Lemaitre, Frank Jülicher, Alf Honigmann, 2024, "Code for: Prewetting of condensates at the apical interface promotes tight junction formation.
Alf Honigmann, PierreDeMarinis
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
BMC Cell Biology, 2010 Background Endothelial tight and adherens junctions control a variety of physiological processes like adhesion, paracellular transport of solutes or trafficking of activated leukocytes. Formation and maintenance of endothelial junctions largely depend on
Beese Michaela +3 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Research progress of
Siliao yanjiu, 2023 Tight junction proteins have been linked to intestinal diseases, the proteins encoded by the Occludin gene are representative of tight junction proteins and play an important role in maintaining the integrity of intestinal barrier function.
DUAN Ji-jiao +7 more
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Rho flares repair local tight junction leaks [PDF]
, 2019 Tight junctions contribute to epithelial barrier function by selectively regulating the quantity and type of molecules that cross the paracellular barrier.
Miller, Ann L. +6 more
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Tight junction physiology of pleural mesothelium
Frontiers in Physiology, 2014 Pleura consists of visceral and parietal cell layers, producing a fluid, which is necessary for lubrication of the pleural space. Function of both mesothelial cell layers is necessary for the regulation of a constant pleural fluid volume and composition ...
Alexander G. Markov, Salah eAmasheh
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