Results 111 to 120 of about 632,604 (307)
A short guide to the tight junction
Journal of Cell ScienceABSTRACT Tight junctions (TJs) are specialized regions of contact between cells of epithelial and endothelial tissues that form selective semipermeable paracellular barriers that establish and maintain body compartments with different fluid compositions.
Sandra Citi +6 more
openaire +3 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Tight Junctions in Salivary Epithelium
Journal of Biomedicine and Biotechnology, 2010 Epithelial cell tight junctions (TJs) consist of a narrow belt-like structure in the apical region of the lateral plasma membrane that circumferentially binds each cell to its neighbor. TJs are found in tissues that are involved in polarized secretions, absorption functions, and maintaining barriers between blood and interstitial fluids. The morphology,
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
, 2019 Wenjing Li,1,2 Chang Xu,1 Kun Wang,1 Yuhan Ding,1 Lei Ding1 1Department of Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Binzhou Medical University Hospital, Binzhou, People’s Republic ...
Li W, Ding Y, Xu C, Wang K, Ding L
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Junction (Gap, Tight, Adherens) Pathways Mechanistic Genes.
, 2012 Junction (Gap, Tight, Adherens) Pathways Mechanistic Genes.
Sangeeta Khare (141487) +11 more
core +1 more source
Bves modulates tight junction associated signaling.
PLoS ONE, 2011 Blood vessel epicardial substance (Bves) is a transmembrane adhesion protein that regulates tight junction (TJ) formation in a variety of epithelia. The role of TJs within epithelium extends beyond the mechanical properties.
Patricia K Russ +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Junction City Notice of Adopted Amendment (2007-07-02)
, 2007 13 pp. Adopted 2007-07-02. Department of Land Conservation and Development Notice of Adopted AmendmentThe applicant is requesting to rezone property from Exclusive Farm Use in Lane County to General Commercial in Junction City.
Junction City (Or.)
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source