Results 111 to 120 of about 301,934 (303)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Uric acid and ammonia play synergistic roles in the loss of blood-brain barrier integrity in the context of hepatic encephalopathy

Fluids and Barriers of the CNS
Background The blood-brain barrier (BBB) maintains brain homeostasis by regulating molecular entry. Its endothelial cells are joined by tight junction proteins and express few apical transporters.
Sydnée L’Ecuyer, Victoria Yip, Maximilian Steger, Farzaneh Tamnanloo, Mariana Oliveira, Mélanie Tremblay, Christopher F. Rose, Emmanuel Charbonney   +7 more
doaj   +1 more source

Impact of residual feed intake on jejunal tight junction morphology and gene expression in slow-growing Korat chickens

Poultry Science
Improving feed efficiency (FE) in Korat chickens (KRC), a Thai slow-growing breed, is essential for reducing production costs. This study aimed to investigate gene and protein expression related to oxidative phosphorylation and tight junction pathways ...
Sukritta Kongthungmon, Saknarin Pengsanthia, Boonyarit Kamkrathok, Pramin Kaewsatuan, Wittawat Molee, Amonrat Molee   +5 more
doaj   +1 more source

Immunocytochemical localization of claudin 1 in the maturation ameloblasts of rat incisors

Frontiers in Physiology, 2010
Claudin 1 is a tight junction transmembrane protein. Its localization in the maturation ameloblasts of rat incisors was examined by immunofluorescence microscopy.
Sumio eNishikawa, Michio eAbe
doaj   +1 more source

Design Rules for High Performance Tunnel Transistors from 2D Materials

, 2016
Tunneling field-effect transistors (TFETs) based on 2D materials are promising steep sub-threshold swing (SS) devices due to their tight gate control. There are two major methods to create the tunnel junction in these 2D TFETs: electrical and chemical ...
Appenzeller, Joerg, Ilatikhameneh, Hesameddin, Klimeck, Gerhard, Rahman, Rajib   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Intestinal tight junctions are severely altered in NEC preterm neonates

Pediatrics and Neonatology, 2018
Background & aims: Necrotizing Enterocolitis (NEC) is a severe inflammatory disorder of the intestine endangering the health and survival of preterm infants.
Amir Bein, Smadar Eventov-Friedman, Dan Arbell, Betty Schwartz   +3 more
doaj   +1 more source

Tight junctions in cancer metastasis

Frontiers in Bioscience, 2011
Tight Junctions (TJ) are well known to function as a control for the paracellular diffusion of ions and certain molecules, it has however, become evident that the TJ has a vital role in maintaining cell to cell integrity. Loss of cohesion of the TJ structure can lead to invasion and ultimately to the metastasis of cancer cells. This review will discuss
Tracey A, Martin, Malcolm D, Mason, Wen G, Jiang   +2 more
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source