Results 101 to 110 of about 1,488,945 (267)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Hybrid Tightly-Coupled SINS/LBL for Underwater Navigation System

IEEE Access
The application of long baseline aided strap-down inertial navigation system (SINS/LBL) has been demonstrated to be an effective solution for accumulative position errors of underwater vehicles (UVs). To address the inefficient positioning when available
Yixian Zhu, Ling Zhou
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tightly-Coupled Radar-Visual-Inertial Odometry

European Journal of Control
Visual-Inertial Odometry (VIO) is a staple for reliable state estimation on constrained and lightweight platforms due to its versatility and demonstrated performance. However, pertinent challenges regarding robust operation in dark, low-texture, obscured environments complicate the use of such methods. Alternatively, Frequency Modulated Continuous Wave
Morten Nissov, Mohit Singh, Kostas Alexis   +2 more
openaire   +2 more sources

Research online: Robust tightly coupled GNSS/INS estimation for navigation

We designed a tightly-coupled integration between GNSS and inertial navigation systems (INS) where we modify the update step of a classical Extended Kalman Filter (EKF) to consider different robust estimators (such as M-estimators). We consider different
Garcia Crespillo, Omar, Meurer, Michael, Skaloud, Jan, Medina, Daniel, Grosch, Anja   +4 more
core  

Tightly-Coupled Heterogeneous Multiprocessing

, 1997
This thesis focuses on identifying the relationship between the major variables which influence the effectiveness of heterogeneous multiprocessing and the resulting performance, as compared to a similar homogeneous multiprocessor.
Andrews, John Barrett
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A Tightly Coupled Region-Shape Framework for 3D

, 2006
Most hybrid 3D segmentation methods either heuristically couple the respective algorithm or combine a true 3D with a 2D algorithm due to computational considerations.
Dimitris N. Metaxas, Rui Huang, Vladimir Pavlovic   +2 more
core  

Tightly-Coupled Multiprocessing for a Global Illumination Algorithm

, 1990
A prevailing trend in computer graphics is the demand for increasingly realistic global illumination models and algorithms. Despite the fact that the computational power of uniprocessors is increasing, it is clear that much greater computational power is
Drettakis, George, Fiume, Eugene, Fournier, Alain   +2 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source