Results 111 to 120 of about 1,488,945 (267)

INS/GPS Tightly Coupled Algorithm based on Unscented Transform

, 2005
In this paper, the tightly coupled INS/GPS integration system based on unscented transform is presented for improving the performance of nonlinear kalman filter.
김광진, 박영범, 박찬국
core  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Nano-GICP tightly-coupled LIO SLAM with graph optimization

Complex & Intelligent Systems
Simultaneous Localisation and Mapping (SLAM) stands as a pivotal technology for large-scale positioning and map construction. During mapping operations in expansive environments, mobile robots incur inherent motion errors alongside point cloud overlaps ...
Qingyong Zhang, Zhennan Lin, Ruilin Dong, Qunxiong Zheng, Chengye Lin   +4 more
doaj   +1 more source

Design of ultra-wideband low-profile antenna based on Vivaldi

Dianzi Jishu Yingyong
In response to the demand for miniaturized ultra-wideband radar systems, a novel ultra-wideband low-profile antenna array is designed with close coupling between antenna elements achieved through a cross-coupling structure.
Guo Dejia, Sun Huifeng
doaj   +1 more source

Climate Simulation Using Tightly Coupled Program And Database

, 2007
We report our experience of tightly coupling a global change simulation of the terrestrial carbon cycle with an object--oriented database. By tightly coupled, we mean an interleaving of computational and data access statements within the same module so ...
David R. Mikesell, John L. Pfaltz, Modules David Mikesell   +2 more
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source