Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L [PDF]
, 2014 Solid tumors are infiltrated by immune cells where macrophages and senescent T cells are highly represented. Within the tumor microenvironment, a cross-talk between the infiltrating cells may occur conditioning the characteristic of the in situ immune ...
Acosta Rodriguez, Eva Virginia +8 more
core +2 more sources
The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis [PDF]
Iranian Journal of Immunology, 2020 Background: Tim-3 has been considered as an ideal target for the immunotherapy of inflammation, but it is unclear whether Tim-3 also plays an important role in acute pancreatitis (AP), as well.
Min Lin +4 more
doaj +1 more source
Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure. [PDF]
, 2017 Vδ2+ γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria.
Bowen, Katherine +17 more
core +2 more sources
Cancer cell intrinsic TIM-3 induces glioblastoma progression
iScience, 2022 Glioblastoma (GBM) is identified to share common signal pathways between glioma and immune cells. Here, we find that T cell immunoglobulin domain and mucin domain protein 3 (TIM-3) is one of the most common co-inhibitory immune checkpoints in GBM shared by tumor and non-tumor cells.
Qing Guo +13 more
openaire +3 more sources
Tim-3 expression defines regulatory T cells in human tumors. [PDF]
PLoS ONE, 2013 Tim-3, a member of the novel Tim (T cell immunoglobulin and mucin domain) family, has been reported to negatively regulate the immune responses against viral infection and had implications for autoimmune disease.
Jing Yan +5 more
doaj +1 more source
Quantitative Expression of C-Type Lectin Receptors in Humans and Mice [PDF]
, 2012 C-type lectin receptors, their adaptor molecules and S-type lectins (galectins) are involved in the recognition of glycosylated self-antigens and pathogens.
Akira +39 more
core +5 more sources
Immunoregulation effects of TIM-3 on tumors
Neoplasma, 2019 Cancer poses a serious threat to human health and its increasing incidence has made it one of the most common causes of death. Immune factors affect in vivo tumor cell survival and expansion, and cancer patients have obvious cell immune dysfunction and low anti-tumor immunity.
C C, Sheng, F Y, Han
openaire +3 more sources
Saved by the Word: The Christian Understanding of the Relationship Between Scripture and Salvation [PDF]
, 1996 Scripture and salvation -- from a Christian point of view, both are gifts from God. yet they are not of equal import. For Christianity salvation is fundamental: it is the goal of life, indeed it is life eternal.
DeRoche, Michael
core +2 more sources
TIM-3 polymorphisms in type 1 diabetes families [PDF]
Journal of Human Genetics, 2008 TIM-3 is a transmembrane protein preferentially expressed on differentiated Th1 cells, which play a role in Th1-mediated diseases including type 1 diabetes. We investigated the role of the rs10515746 (A/C), rs1036199 (A/C), and rs10053538 (A/C) single nucleotide polymorphisms (SNPs) within the TIM-3 gene in 186 German type 1 diabetes families (558 ...
Patrick, Brück +4 more
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2021 Vertical transmission of Toxoplasma gondii (T. gondii) infection during gestation can result in severe complications such as abortion, congenital malformation, fetal teratogenesis, etc.
Teng Li +8 more
doaj +1 more source