Results 51 to 60 of about 17,630,315 (317)

Increased TIM-3 expression in tumor-associated macrophages predicts a poorer prognosis in non-small cell lung cancer: a retrospective cohort study

Journal of Thoracic Disease, 2023
Background T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) is considered a key negative regulator in T-cell-mediated response. However, few studies have been reported on the relationship between TIM-3 expression in tumor-associated ...
Chi Zhang, Liyun Xu, Yongbin Ma, Yanyan Huang, Lu Zhou, Han-Bo Le, Zhi-jun Chen   +6 more
semanticscholar   +1 more source

Association of TIM-1 5383-5397ins/del and TIM-3-1541C > T polymorphisms with multiple sclerosis in Isfahan population [PDF]

, 2016
Multiple sclerosis (MS) is an organ-specific autoimmune disease in central nervous system, affecting about 2.5 million people around the world. Probable involvement of two newly identified immunoregulator molecules, TIM-1 and TIM-3, has been reported in ...
Alesahebfosoul, Fereshteh., Etemadifar, Masoud., Ganjalikhani-Hakemi, Mazdak., Mazrouei, Fariba., Meshkat, Rezvan., Nekoueian, Sh., Pouladian, Majid., Salehi, Rasoul., Zarkesh Esfahani, Hamid., Ziyaee-Ghahnaviyeh, M.   +9 more
core   +1 more source

TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway. [PDF]

PLoS ONE, 2015
TIM-3 (T cell immunoglobulin and mucin-domain containing protein 3) is a member of the TIM family of proteins that is preferentially expressed on Th1 polarized CD4+ and CD8+ T cells.
Brian Tomkowicz, Eileen Walsh, Adam Cotty, Raluca Verona, Nina Sabins, Fred Kaplan, Sandy Santulli-Marotto, Chen-Ni Chin, Jill Mooney, Russell B Lingham, Michael Naso, Timothy McCabe   +11 more
doaj   +1 more source

Increased co-expression of TIM-3 with TIGIT or 2B4 on CD8+ T cells is associated with poor prognosis in locally advanced nasopharyngeal carcinoma

Biomolecules & Biomedicine, 2023
The use of immune checkpoint inhibitors in malignant tumors improves patient outcomes. Because single-agent immune checkpoint blockade has a low objective response rate, it is meaningful to explore combined blockade of immune checkpoint receptors.
Xiaolin Xie, Yaning Feng, Peiwen Fan, Danning Dong, Xuan Yao, Yanchun Peng, Ruozheng Wang   +6 more
doaj   +1 more source

Tim-3 regulates the immunosuppressive function of decidual MDSCs via the Fyn-STAT3-C/EBPβ pathway during Toxoplasma gondii infection

PLoS Pathogens, 2023
Myeloid-derived suppressor cells (MDSCs) play a key role in maintaining maternal-fetal tolerance for a successful pregnancy, but the role of MDSCs in abnormal pregnancy caused by Toxoplasma gondii infection is unknown.
Houbao Qi, Yuantao Li, Xianbing Liu, Yuzhu Jiang, Zhidan Li, Xiaoyan Xu, Hai-xia Zhang, Xuemei Hu   +7 more
semanticscholar   +1 more source

Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L [PDF]

, 2014
Solid tumors are infiltrated by immune cells where macrophages and senescent T cells are highly represented. Within the tumor microenvironment, a cross-talk between the infiltrating cells may occur conditioning the characteristic of the in situ immune ...
Acosta Rodriguez, Eva Virginia, Canale, Fernando Pablo, Gastman, B, Gruppi, Adriana, Mena, Hebe Agustina, Montes, Carolina Lucia, Negrotto, Soledad, Ramello, María Cecilia, Tosello Boari, Jimena   +8 more
core   +2 more sources

Combined TIM-3 and PD-1 blockade restrains hepatocellular carcinoma development by facilitating CD4+ and CD8+ T cell-mediated antitumor immune responses

World Journal of Gastrointestinal Oncology, 2023
BACKGROUND Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1) and T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) are beneficial to the resumption of anti-tumor immunity response and hold extreme ...
Xusheng Zhang, Hongyan Zhou, Peng Wei, Long Chen, Wei Ma, Lin Ding, Shi-Cai Liang, Ben-Dong Chen   +7 more
semanticscholar   +1 more source

Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure. [PDF]

, 2017
Vδ2+ γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria.
Bowen, Katherine, Boyle, Michelle J, Budker, Rachel, Dorsey, Grant, Farrington, Lila A, Feeney, Margaret E, Greenhouse, Bryan, Jagannathan, Prasanna, Kamya, Moses R, Katureebe, Agaba, Lutwama, Fredrick, McIntyre, Tara I, Musinguzi, Kenneth, Nalubega, Mayimuna, Naluwu, Kate, Nankya, Felistas, Rek, John, Sikyomu, Esther   +17 more
core   +2 more sources

Quantitative Expression of C-Type Lectin Receptors in Humans and Mice [PDF]

, 2012
C-type lectin receptors, their adaptor molecules and S-type lectins (galectins) are involved in the recognition of glycosylated self-antigens and pathogens.
Akira, Anders, Bjorge, Camby, Caminschi, Christoph Römmele, Elola, Ferwerda, Geijtenbeek, Gingras, Gringhuis, Gross, Hans-Joachim Anders, Heil, Heni Eka Susanti, Hornung, Kimbrell, Kock, Kono, Kronin, Kulkarni, Lassen, Lech, Lech, Lech, Lopez-Guisa, Maciej Lech, Medzhitov, Mocsai, Osorio, Patole, Rakoff-Nahoum, Regina Gröbmayr, Roman Günthner, Schreibelt, Skuginna, Van Vliet, Wagner, Zarember, Zhang   +39 more
core   +5 more sources

Cancer cell intrinsic TIM-3 induces glioblastoma progression

iScience, 2022
Glioblastoma (GBM) is identified to share common signal pathways between glioma and immune cells. Here, we find that T cell immunoglobulin domain and mucin domain protein 3 (TIM-3) is one of the most common co-inhibitory immune checkpoints in GBM shared by tumor and non-tumor cells.
Qing Guo, Shuai Shen, Gefei Guan, Chen Zhu, Cunyi Zou, Jingyuan Cao, Wen Cheng, Xiaoyan Xu, Juanhan Yu, Zhiguo Lin, Guoli Wang, Ling Chen, Peng Cheng, Anhua Wu   +13 more
openaire   +3 more sources