Results 51 to 60 of about 159,423 (276)

Polyfunctional Melan-A-specific tumor-reactive CD8+ T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS [PDF]

, 2016
The identification of activation pathways linked to anti-tumor T-cell polyfunctionality in long surviving patients is of great relevance in the new era of immunotherapy.
Belinda, Palermobc, Cosmo Di, Donnac, GISMONDI, Angela, Isabella, Sperdutid, Ornella, Franzesea, SANTONI, Angela, STABILE, MARIA HELENA, Virginia, Ferraresie   +7 more
core   +1 more source

Editorial: Tim-3 puts on the brakes [PDF]

Journal of Leukocyte Biology, 2012
Discussion on how Tim-3 negatively regulates both innate and adaptive immune responses.
openaire   +2 more sources

Analysis of Tim-3 as a therapeutic target in prostate cancer

Tumor Biology, 2017
Tim-3 (T-cell immunoglobulin domain and mucin domain–containing molecule 3) is a newly discovered immunomodulatory protein, which plays an important role in immunity regulation. Recent evidence suggests that Tim-3 is differentially regulated in a variety
Yongrui Piao, Xuanshun Jin
doaj   +1 more source

Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway

Molecular Metabolism, 2019
Objective: Macrophage-mediated inflammation plays a significant role in the development and progression of diabetic nephropathy (DN). However, the underlying mechanisms remain unclear. Studies suggest that T cell immunoglobulin domain and mucin domain-3 (
Huimin Yang, Tingting Xie, Dengren Li, Xianhong Du, Tixiao Wang, Chunyang Li, Xiaojia Song, Leiqi Xu, Fan Yi, Xiaohong Liang, Lifen Gao, Xiangdong Yang, Chunhong Ma   +12 more
doaj   +1 more source

Motivation to shape the future of education with Artificial Intelligence: An international comparison between Switzerland and China

Computers and Education Open
As digital technologies and Artificial Intelligence (AI) continue to reshape educational environments, understanding the motivations of student teachers is critical to developing effective teacher education programmes.
Judit Martínez-Moreno, Xinyan Zhou, Dominik Petko, Thomas K.F. Chiu   +3 more
doaj   +1 more source

The inhibitory receptor Tim-3 fails to suppress IFN-γ production via the NFAT pathway in NK-cell, unlike that in CD4+ T cells

BMC Immunology, 2021
Background T cell immunoglobulin and mucin domain-containing-3 (Tim-3) is a negative regulator expressed on T cells, and is also expressed on natural killer (NK) cells.
Xiaowen Yu, Bin Lang, Xi Chen, Yao Tian, Shi Qian, Zining Zhang, Yajing Fu, Junjie Xu, Xiaoxu Han, Haibo Ding, Yongjun Jiang   +10 more
doaj   +1 more source

Establishment of novel anti-TIM-3 antibodies interfering with its binding to ligands

Heliyon
The T cell immunoglobulin and mucin-domain containing-3 (TIM-3) receptor has gained significant attention as a promising target for cancer immunotherapy.
Zhuohong Yan, Teng Ma, Xiaojue Wang, Ling Yi, Panjian Wei, Hongtao Zhang, Jinghui Wang   +6 more
doaj   +1 more source

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development

Molecular Therapy, 2022
The spatial organization of immune cells within the tumor microenvironment (TME) largely determines the anti-tumor immunity and also highly predicts tumor progression and therapeutic response. Tim-3 is a well-accepted immune checkpoint and plays multifaceted immunoregulatory roles via interaction with distinct Tim-3 ligands (Tim-3L), showing great ...
Tixiao, Wang, Jie, Zhang, Na, Li, Mengzhen, Li, Shuaiya, Ma, Siyu, Tan, Xiaowei, Guo, Zehua, Wang, Zhuanchang, Wu, Lifen, Gao, Chunhong, Ma, Xiaohong, Liang   +11 more
openaire   +2 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source