Results 61 to 70 of about 17,630,315 (317)
Tim-3 expression defines regulatory T cells in human tumors. [PDF]
PLoS ONE, 2013 Tim-3, a member of the novel Tim (T cell immunoglobulin and mucin domain) family, has been reported to negatively regulate the immune responses against viral infection and had implications for autoimmune disease.
Jing Yan +5 more
doaj +1 more source
The Immunomodulatory Effects and Mechanisms of Tim-3 Action in the Early Stage of Mice with Severe Acute Pancreatitis [PDF]
Iranian Journal of Immunology, 2020 Background: Tim-3 has been considered as an ideal target for the immunotherapy of inflammation, but it is unclear whether Tim-3 also plays an important role in acute pancreatitis (AP), as well.
Min Lin +4 more
doaj +1 more source
Polyfunctional Melan-A-specific tumor-reactive CD8+ T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS [PDF]
, 2016 The identification of activation pathways linked to anti-tumor T-cell polyfunctionality in long surviving patients is of great relevance in the new era of immunotherapy.
Belinda, Palermobc +7 more
core +1 more source
Immunoregulation effects of TIM-3 on tumors
Neoplasma, 2019 Cancer poses a serious threat to human health and its increasing incidence has made it one of the most common causes of death. Immune factors affect in vivo tumor cell survival and expansion, and cancer patients have obvious cell immune dysfunction and low anti-tumor immunity.
C C, Sheng, F Y, Han
openaire +3 more sources
Molecular Metabolism, 2019 Objective: Macrophage-mediated inflammation plays a significant role in the development and progression of diabetic nephropathy (DN). However, the underlying mechanisms remain unclear. Studies suggest that T cell immunoglobulin domain and mucin domain-3 (
Huimin Yang +12 more
doaj +1 more source
Cancers, 2023 Simple Summary TGFβ and TIM-3 have been implicated in driving immune evasion and poor response to anti-PD-1/PD-L1 immune checkpoint inhibitors (ICIs).
Masanori Katagata +13 more
semanticscholar +1 more source
Saved by the Word: The Christian Understanding of the Relationship Between Scripture and Salvation [PDF]
, 1996 Scripture and salvation -- from a Christian point of view, both are gifts from God. yet they are not of equal import. For Christianity salvation is fundamental: it is the goal of life, indeed it is life eternal.
DeRoche, Michael
core +2 more sources
TIM-3 polymorphisms in type 1 diabetes families [PDF]
Journal of Human Genetics, 2008 TIM-3 is a transmembrane protein preferentially expressed on differentiated Th1 cells, which play a role in Th1-mediated diseases including type 1 diabetes. We investigated the role of the rs10515746 (A/C), rs1036199 (A/C), and rs10053538 (A/C) single nucleotide polymorphisms (SNPs) within the TIM-3 gene in 186 German type 1 diabetes families (558 ...
Patrick, Brück +4 more
openaire +2 more sources
T cell CEACAM1 - TIM-3 crosstalk alleviates liver transplant injury in mice and humans.
Gastroenterology, 2023 BACKGROUND&AIMS CEACAM1 (CC1) acts through homophilic and heterophilic interactions with TIM-3, which regulates innate immune activation in orthotopic liver transplantation (OLT).
H. Kojima +9 more
semanticscholar +1 more source
Editorial: Tim-3 puts on the brakes [PDF]
Journal of Leukocyte Biology, 2012 Discussion on how Tim-3 negatively regulates both innate and adaptive immune responses.
openaire +2 more sources