Results 81 to 90 of about 29,851,130 (293)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
MathematicsThis paper introduces an extremum seeking (ES) scheme for the unknown map’s first derivative by tailoring a demodulation signal in which the closed-loop system is subject to constant transmission delays.
Jianzhong Li, Hongye Su, Yang Zhu
doaj +1 more source
A real-time vision system for telerobotic manipulator with large time delay
, 2012 This paper presents a real-time vision system for telerobotic manipulator with large time delay. This system consists of a number of subsystems, including image acquisition system, image transmission system, object tracking system and pose estimation ...
Tian JD(田建东) +4 more
core
Time Delay Compensation and Stability Analysis of Networked Predictive Control Systems Based on Hammerstein Model [PDF]
, 2007 A novel approach is proposed for a networked control system with random delays containing a nonlinear process based on a Hammerstein model. The method uses a time delay two step generalized predictive control (TDTSGPC), which consists of two parts, one ...
G.P. Liu +5 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Robust H∞ control for a class of nonlinear discrete time-delay stochastic systems with missing measurements [PDF]
, 2009 This is the post print version of the article. The official published version can be obtained from the link - Copyright 2009 Elsevier LtdThis paper is concerned with the problem of robust H∞ output feedback control for a class of uncertain discrete-time ...
Liu, Y, Liu, X, Wang, Z, Ho, DWC
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Stability of a time discrete perturbed dynamical system with delay
Discrete Dynamics in Nature and Society, 1999 Let Cn be the set of n complex vectors endowed with a norm ‖⋅‖Cn. Let A,B be two complex n×n matrices and τ a positive integer. In the present paper we consider the nonlinear difference equation with delay of the type uk+1=Auk+Buk−τ+Fk(uk,uk−τ), k=0,
Michael I. Gil', Sui Sun Cheng
doaj +1 more source